Marked Differences in the Effect of Antiepileptic and Cytostatic Drugs on the Functionality of P-Glycoprotein in Human and Rat Brain ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-30

AUTHORS

Dana Alms, Maren Fedrowitz, Kerstin Römermann, Andreas Noack, Wolfgang Löscher

ABSTRACT

ABSTRACTPurposeThe expression of P-glycoprotein (Pgp) is increased in brain capillary endothelial cells (BCECs) of patients with pharmacoresistant epilepsy. This may restrict the penetration of antiepileptic drugs (AEDs) into the brain. However, the mechanisms underlying increased Pgp expression in epilepsy patients are not known. One possibility is that AEDs induce the expression and functionality of Pgp in BCECs. Several older AEDs that induce human cytochrome P450 enzymes also induce Pgp in hepatocytes and enterocytes, but whether this extends to Pgp at the human BBB and to newer AEDs is not known.MethodsThis prompted us to study the effects of various old and new AEDs on Pgp functionality in the human BCEC line, hCMEC/D3, using the rhodamine 123 (Rho123) efflux assay. For comparison, experiments were performed in two rat BCEC lines, RBE4 and GPNT, and primary cultures of rat and pig BCECs. Furthermore, known Pgp inducers, such as dexamethasone and several cytostatic drugs, were included in our experiments.ResultsUnder control conditions, GPNT cells exhibited the highest and RBE4 the lowest Pgp expression and Rho123 efflux, while intermediate values were determined in hCMEC/D3. Known Pgp inducers increased Rho123 efflux in all cell lines, but marked inter-cell line differences in effect size were observed. Of the various AEDs examined, only carbamazepine (100 μM) moderately increased Pgp functionality in hCMEC/D3, while valproate (300 μM) inhibited Pgp.ConclusionsThese data do not indicate that treatment with AEDs causes a clinically relevant induction in Pgp functionality in BCECs that form the BBB. More... »

PAGES

1588-1604

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-013-1264-4

DOI

http://dx.doi.org/10.1007/s11095-013-1264-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046584146

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24477677


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ATP Binding Cassette Transporter, Subfamily B, Member 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Inflammatory Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticonvulsants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capillaries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Primary Cell Culture", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Center for Systems Neuroscience, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.412970.9", 
          "name": [
            "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany", 
            "Center for Systems Neuroscience, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alms", 
        "givenName": "Dana", 
        "id": "sg:person.0731157732.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731157732.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.412970.9", 
          "name": [
            "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fedrowitz", 
        "givenName": "Maren", 
        "id": "sg:person.01130031444.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130031444.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.412970.9", 
          "name": [
            "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00f6mermann", 
        "givenName": "Kerstin", 
        "id": "sg:person.0777273132.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777273132.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.412970.9", 
          "name": [
            "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noack", 
        "givenName": "Andreas", 
        "id": "sg:person.01041545232.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041545232.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Systems Neuroscience, Hannover, Germany", 
          "id": "http://www.grid.ac/institutes/grid.412970.9", 
          "name": [
            "Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, B\u00fcnteweg 17, 30559, Hannover, Germany", 
            "Center for Systems Neuroscience, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f6scher", 
        "givenName": "Wolfgang", 
        "id": "sg:person.011230603547.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011230603547.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10571-009-9431-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010090976", 
          "https://doi.org/10.1007/s10571-009-9431-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10571-004-1376-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051913763", 
          "https://doi.org/10.1007/s10571-004-1376-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.clpt.2004.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034530663", 
          "https://doi.org/10.1016/j.clpt.2004.04.011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02977789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044287035", 
          "https://doi.org/10.1007/bf02977789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014912203", 
          "https://doi.org/10.1038/nrn1728"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-01-30", 
    "datePublishedReg": "2014-01-30", 
    "description": "ABSTRACTPurposeThe expression of P-glycoprotein (Pgp) is increased in brain capillary endothelial cells (BCECs) of patients with pharmacoresistant epilepsy. This may restrict the penetration of antiepileptic drugs (AEDs) into the brain. However, the mechanisms underlying increased Pgp expression in epilepsy patients are not known. One possibility is that AEDs induce the expression and functionality of Pgp in BCECs. Several older AEDs that induce human cytochrome P450 enzymes also induce Pgp in hepatocytes and enterocytes, but whether this extends to Pgp at the human BBB and to newer AEDs is not known.MethodsThis prompted us to study the effects of various old and new AEDs on Pgp functionality in the human BCEC line, hCMEC/D3, using the rhodamine 123 (Rho123) efflux assay. For comparison, experiments were performed in two rat BCEC lines, RBE4 and GPNT, and primary cultures of rat and pig BCECs. Furthermore, known Pgp inducers, such as dexamethasone and several cytostatic drugs, were included in our experiments.ResultsUnder control conditions, GPNT cells exhibited the highest and RBE4 the lowest Pgp expression and Rho123 efflux, while intermediate values were determined in hCMEC/D3. Known Pgp inducers increased Rho123 efflux in all cell lines, but marked inter-cell line differences in effect size were observed. Of the various AEDs examined, only carbamazepine (100\u00a0\u03bcM) moderately increased Pgp functionality in hCMEC/D3, while valproate (300\u00a0\u03bcM) inhibited Pgp.ConclusionsThese data do not indicate that treatment with AEDs causes a clinically relevant induction in Pgp functionality in BCECs that form the BBB.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11095-013-1264-4", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "brain capillary endothelial cells", 
      "new antiepileptic drugs", 
      "antiepileptic drugs", 
      "hCMEC/D3", 
      "Pgp functionality", 
      "Pgp inducers", 
      "Rho123 efflux", 
      "Pgp expression", 
      "Rhodamine 123 efflux assay", 
      "cytostatic drugs", 
      "rat brain capillary endothelial cell line", 
      "effects of antiepileptics", 
      "older antiepileptic drugs", 
      "brain capillary endothelial cell line", 
      "low Pgp expression", 
      "cell lines", 
      "capillary endothelial cells", 
      "human cytochrome P450", 
      "GPNT cells", 
      "endothelial cell line", 
      "ResultsUnder control conditions", 
      "human BBB", 
      "pharmacoresistant epilepsy", 
      "relevant induction", 
      "epilepsy patients", 
      "ConclusionsThese data", 
      "efflux assays", 
      "endothelial cells", 
      "primary cultures", 
      "drugs", 
      "patients", 
      "Pgp", 
      "D3", 
      "cytochrome P450", 
      "BBB", 
      "RBE4", 
      "effect size", 
      "control condition", 
      "line differences", 
      "expression", 
      "efflux", 
      "marked differences", 
      "inducer", 
      "glycoprotein", 
      "cells", 
      "MethodsThis", 
      "antiepileptics", 
      "epilepsy", 
      "GPNT", 
      "rats", 
      "brain", 
      "enterocytes", 
      "carbamazepine", 
      "treatment", 
      "differences", 
      "hepatocytes", 
      "induction", 
      "P450", 
      "assays", 
      "effect", 
      "humans", 
      "lines", 
      "culture", 
      "mechanism", 
      "data", 
      "comparison", 
      "penetration", 
      "intermediate values", 
      "possibility", 
      "values", 
      "conditions", 
      "size", 
      "experiments", 
      "functionality", 
      "ABSTRACTPurposeThe expression", 
      "functionality of Pgp", 
      "human BCEC line", 
      "BCEC line", 
      "rat BCEC lines", 
      "pig BCECs", 
      "Known Pgp inducers", 
      "inter-cell line differences", 
      "Capillary Endothelial Cell Lines"
    ], 
    "name": "Marked Differences in the Effect of Antiepileptic and Cytostatic Drugs on the Functionality of P-Glycoprotein in Human and Rat Brain Capillary Endothelial Cell Lines", 
    "pagination": "1588-1604", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046584146"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11095-013-1264-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24477677"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11095-013-1264-4", 
      "https://app.dimensions.ai/details/publication/pub.1046584146"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_626.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11095-013-1264-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-013-1264-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-013-1264-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-013-1264-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-013-1264-4'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      22 PREDICATES      128 URIs      115 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11095-013-1264-4 schema:about N00c7bbaf84e74d3e8c508266d75d47e1
2 N18beaabc0b8949c5aeb3f18b0025480c
3 N2ae3839e6285462daf0b3fdde609327c
4 N5380b5fdc5b84789a2f39401e2859d36
5 N61bb75f74ca349929df4154679b25305
6 N634c450de7824d929f08b53b618cf6c2
7 N659d6c422a594a9aacac6fd393cfc1ea
8 N6f5358d742ec49fb883392fa86c0a08f
9 N9d709edc697d405ab13269001b64adf6
10 Nb4d07274baf44d6ab613ec43be75f004
11 Nc28cf544ac7e499eb557352058e7c102
12 Nde1b3598573949d9b893f3827f1364b8
13 Ne84d7598942b4d0985f2924be6bcf093
14 Nf3ee711b42304dc990c7af34579da623
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author N910d33896de44e759e42721e1a34b3b7
18 schema:citation sg:pub.10.1007/bf02977789
19 sg:pub.10.1007/s10571-004-1376-9
20 sg:pub.10.1007/s10571-009-9431-1
21 sg:pub.10.1016/j.clpt.2004.04.011
22 sg:pub.10.1038/nrn1728
23 schema:datePublished 2014-01-30
24 schema:datePublishedReg 2014-01-30
25 schema:description ABSTRACTPurposeThe expression of P-glycoprotein (Pgp) is increased in brain capillary endothelial cells (BCECs) of patients with pharmacoresistant epilepsy. This may restrict the penetration of antiepileptic drugs (AEDs) into the brain. However, the mechanisms underlying increased Pgp expression in epilepsy patients are not known. One possibility is that AEDs induce the expression and functionality of Pgp in BCECs. Several older AEDs that induce human cytochrome P450 enzymes also induce Pgp in hepatocytes and enterocytes, but whether this extends to Pgp at the human BBB and to newer AEDs is not known.MethodsThis prompted us to study the effects of various old and new AEDs on Pgp functionality in the human BCEC line, hCMEC/D3, using the rhodamine 123 (Rho123) efflux assay. For comparison, experiments were performed in two rat BCEC lines, RBE4 and GPNT, and primary cultures of rat and pig BCECs. Furthermore, known Pgp inducers, such as dexamethasone and several cytostatic drugs, were included in our experiments.ResultsUnder control conditions, GPNT cells exhibited the highest and RBE4 the lowest Pgp expression and Rho123 efflux, while intermediate values were determined in hCMEC/D3. Known Pgp inducers increased Rho123 efflux in all cell lines, but marked inter-cell line differences in effect size were observed. Of the various AEDs examined, only carbamazepine (100 μM) moderately increased Pgp functionality in hCMEC/D3, while valproate (300 μM) inhibited Pgp.ConclusionsThese data do not indicate that treatment with AEDs causes a clinically relevant induction in Pgp functionality in BCECs that form the BBB.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N798252ec9ba34b2e926bdf21b7f60f00
30 N81fbc399c94b43c08e8f5d8278dd8a4a
31 sg:journal.1094644
32 schema:keywords ABSTRACTPurposeThe expression
33 BBB
34 BCEC line
35 Capillary Endothelial Cell Lines
36 ConclusionsThese data
37 D3
38 GPNT
39 GPNT cells
40 Known Pgp inducers
41 MethodsThis
42 P450
43 Pgp
44 Pgp expression
45 Pgp functionality
46 Pgp inducers
47 RBE4
48 ResultsUnder control conditions
49 Rho123 efflux
50 Rhodamine 123 efflux assay
51 antiepileptic drugs
52 antiepileptics
53 assays
54 brain
55 brain capillary endothelial cell line
56 brain capillary endothelial cells
57 capillary endothelial cells
58 carbamazepine
59 cell lines
60 cells
61 comparison
62 conditions
63 control condition
64 culture
65 cytochrome P450
66 cytostatic drugs
67 data
68 differences
69 drugs
70 effect
71 effect size
72 effects of antiepileptics
73 efflux
74 efflux assays
75 endothelial cell line
76 endothelial cells
77 enterocytes
78 epilepsy
79 epilepsy patients
80 experiments
81 expression
82 functionality
83 functionality of Pgp
84 glycoprotein
85 hCMEC/D3
86 hepatocytes
87 human BBB
88 human BCEC line
89 human cytochrome P450
90 humans
91 inducer
92 induction
93 inter-cell line differences
94 intermediate values
95 line differences
96 lines
97 low Pgp expression
98 marked differences
99 mechanism
100 new antiepileptic drugs
101 older antiepileptic drugs
102 patients
103 penetration
104 pharmacoresistant epilepsy
105 pig BCECs
106 possibility
107 primary cultures
108 rat BCEC lines
109 rat brain capillary endothelial cell line
110 rats
111 relevant induction
112 size
113 treatment
114 values
115 schema:name Marked Differences in the Effect of Antiepileptic and Cytostatic Drugs on the Functionality of P-Glycoprotein in Human and Rat Brain Capillary Endothelial Cell Lines
116 schema:pagination 1588-1604
117 schema:productId N1962d319cc11495d8d4622485797eb1d
118 N891994e75a84483d929624f605a3f7ce
119 Nceff6ec8046a4b30bb44dde9a01de03d
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046584146
121 https://doi.org/10.1007/s11095-013-1264-4
122 schema:sdDatePublished 2021-11-01T18:21
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N8ca07b7f24fd4468a4a61f0fb81c5651
125 schema:url https://doi.org/10.1007/s11095-013-1264-4
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N00c7bbaf84e74d3e8c508266d75d47e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Brain
131 rdf:type schema:DefinedTerm
132 N18beaabc0b8949c5aeb3f18b0025480c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Capillaries
134 rdf:type schema:DefinedTerm
135 N1962d319cc11495d8d4622485797eb1d schema:name dimensions_id
136 schema:value pub.1046584146
137 rdf:type schema:PropertyValue
138 N2ae3839e6285462daf0b3fdde609327c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Anti-Inflammatory Agents
140 rdf:type schema:DefinedTerm
141 N5380b5fdc5b84789a2f39401e2859d36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Anticonvulsants
143 rdf:type schema:DefinedTerm
144 N61bb75f74ca349929df4154679b25305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Endothelial Cells
146 rdf:type schema:DefinedTerm
147 N634c450de7824d929f08b53b618cf6c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Swine
149 rdf:type schema:DefinedTerm
150 N659d6c422a594a9aacac6fd393cfc1ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Primary Cell Culture
152 rdf:type schema:DefinedTerm
153 N6f5358d742ec49fb883392fa86c0a08f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Humans
155 rdf:type schema:DefinedTerm
156 N798252ec9ba34b2e926bdf21b7f60f00 schema:issueNumber 6
157 rdf:type schema:PublicationIssue
158 N7d54e621765b4c35a5d28522d5135443 rdf:first sg:person.0777273132.71
159 rdf:rest Nddc0eeca6f694a17ac86a3572e6bc930
160 N81fbc399c94b43c08e8f5d8278dd8a4a schema:volumeNumber 31
161 rdf:type schema:PublicationVolume
162 N840345fee2394563929ff2a72c13b1a8 rdf:first sg:person.01130031444.09
163 rdf:rest N7d54e621765b4c35a5d28522d5135443
164 N891994e75a84483d929624f605a3f7ce schema:name doi
165 schema:value 10.1007/s11095-013-1264-4
166 rdf:type schema:PropertyValue
167 N8ca07b7f24fd4468a4a61f0fb81c5651 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N910d33896de44e759e42721e1a34b3b7 rdf:first sg:person.0731157732.33
170 rdf:rest N840345fee2394563929ff2a72c13b1a8
171 N95a1f958d01b4ccab3467279b4511586 rdf:first sg:person.011230603547.08
172 rdf:rest rdf:nil
173 N9d709edc697d405ab13269001b64adf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Rats
175 rdf:type schema:DefinedTerm
176 Nb4d07274baf44d6ab613ec43be75f004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Animals
178 rdf:type schema:DefinedTerm
179 Nc28cf544ac7e499eb557352058e7c102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Dexamethasone
181 rdf:type schema:DefinedTerm
182 Nceff6ec8046a4b30bb44dde9a01de03d schema:name pubmed_id
183 schema:value 24477677
184 rdf:type schema:PropertyValue
185 Nddc0eeca6f694a17ac86a3572e6bc930 rdf:first sg:person.01041545232.48
186 rdf:rest N95a1f958d01b4ccab3467279b4511586
187 Nde1b3598573949d9b893f3827f1364b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name ATP Binding Cassette Transporter, Subfamily B, Member 1
189 rdf:type schema:DefinedTerm
190 Ne84d7598942b4d0985f2924be6bcf093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Cell Line
192 rdf:type schema:DefinedTerm
193 Nf3ee711b42304dc990c7af34579da623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Antineoplastic Agents
195 rdf:type schema:DefinedTerm
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
200 schema:name Neurosciences
201 rdf:type schema:DefinedTerm
202 sg:journal.1094644 schema:issn 0724-8741
203 1573-904X
204 schema:name Pharmaceutical Research
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.01041545232.48 schema:affiliation grid-institutes:grid.412970.9
208 schema:familyName Noack
209 schema:givenName Andreas
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041545232.48
211 rdf:type schema:Person
212 sg:person.011230603547.08 schema:affiliation grid-institutes:grid.412970.9
213 schema:familyName Löscher
214 schema:givenName Wolfgang
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011230603547.08
216 rdf:type schema:Person
217 sg:person.01130031444.09 schema:affiliation grid-institutes:grid.412970.9
218 schema:familyName Fedrowitz
219 schema:givenName Maren
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130031444.09
221 rdf:type schema:Person
222 sg:person.0731157732.33 schema:affiliation grid-institutes:grid.412970.9
223 schema:familyName Alms
224 schema:givenName Dana
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731157732.33
226 rdf:type schema:Person
227 sg:person.0777273132.71 schema:affiliation grid-institutes:grid.412970.9
228 schema:familyName Römermann
229 schema:givenName Kerstin
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777273132.71
231 rdf:type schema:Person
232 sg:pub.10.1007/bf02977789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044287035
233 https://doi.org/10.1007/bf02977789
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s10571-004-1376-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051913763
236 https://doi.org/10.1007/s10571-004-1376-9
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s10571-009-9431-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010090976
239 https://doi.org/10.1007/s10571-009-9431-1
240 rdf:type schema:CreativeWork
241 sg:pub.10.1016/j.clpt.2004.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034530663
242 https://doi.org/10.1016/j.clpt.2004.04.011
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nrn1728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014912203
245 https://doi.org/10.1038/nrn1728
246 rdf:type schema:CreativeWork
247 grid-institutes:grid.412970.9 schema:alternateName Center for Systems Neuroscience, Hannover, Germany
248 Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bünteweg 17, 30559, Hannover, Germany
249 schema:name Center for Systems Neuroscience, Hannover, Germany
250 Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bünteweg 17, 30559, Hannover, Germany
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...