Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Yin-Ku Lin, Saleh A. Al-Suwayeh, Yann-Lii Leu, Feng-Ming Shen, Jia-You Fang

ABSTRACT

PURPOSE: Diphencyprone (DPCP) is a therapeutic agent for treating alopecia areata. To improve skin absorption and follicular targeting nanostructured lipid carriers (NLCs) were developed. METHODS: Nanoparticles were characterized by size, zeta potential, molecular environment, differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR). In vitro and in vivo skin absorption experiments were performed. Fluorescence and confocal microscopes for imaging skin distribution were used. RESULTS: NLCs with different designs were 208 ~ 265 nm with > 77% DPCP encapsulation. NLCs incorporating a cationic surfactant or more soybean phosphatidylcholine (SPC) showed higher lipophilicity compared to typical NLCs by Nile red emission. All NLCs tested revealed controlled DPCP release; burst release was observed for control. The formulation with more SPC provided 275 μg/g DPCP skin retention, which was greater than control and other NLCs. Intersubject deviation was reduced after DPCP loading into NLCs. Cyanoacrylate skin biopsy demonstrated greater follicular deposition for NLCs with more SPC compared to control. Cationic NLCs but not typical or SPC-containing carriers were largely internalized into keratinocytes. In vivo skin retention of NLCs with more SPC was higher than free control. Confocal imaging confirmed localization of NLCs in follicles and intercellular lipids of stratum corneum. CONCLUSIONS: This work encourages further investigation of DPCP absorption using NLCs with a specific formulation design. More... »

PAGES

435-446

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0

DOI

http://dx.doi.org/10.1007/s11095-012-0888-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052368670

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23070602


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'


 

This table displays all metadata directly associated to this object as RDF triples.

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298 Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, 333, Kweishan, Taoyuan, Taiwan
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.454209.e schema:alternateName Keelung Chang Gung Memorial Hospital
301 schema:name Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
302 School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.56302.32 schema:alternateName King Saud University
305 schema:name Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
306 rdf:type schema:Organization
 




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