Ontology type: schema:ScholarlyArticle
2013-02
AUTHORSYin-Ku Lin, Saleh A. Al-Suwayeh, Yann-Lii Leu, Feng-Ming Shen, Jia-You Fang
ABSTRACTPURPOSE: Diphencyprone (DPCP) is a therapeutic agent for treating alopecia areata. To improve skin absorption and follicular targeting nanostructured lipid carriers (NLCs) were developed. METHODS: Nanoparticles were characterized by size, zeta potential, molecular environment, differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR). In vitro and in vivo skin absorption experiments were performed. Fluorescence and confocal microscopes for imaging skin distribution were used. RESULTS: NLCs with different designs were 208 ~ 265 nm with > 77% DPCP encapsulation. NLCs incorporating a cationic surfactant or more soybean phosphatidylcholine (SPC) showed higher lipophilicity compared to typical NLCs by Nile red emission. All NLCs tested revealed controlled DPCP release; burst release was observed for control. The formulation with more SPC provided 275 μg/g DPCP skin retention, which was greater than control and other NLCs. Intersubject deviation was reduced after DPCP loading into NLCs. Cyanoacrylate skin biopsy demonstrated greater follicular deposition for NLCs with more SPC compared to control. Cationic NLCs but not typical or SPC-containing carriers were largely internalized into keratinocytes. In vivo skin retention of NLCs with more SPC was higher than free control. Confocal imaging confirmed localization of NLCs in follicles and intercellular lipids of stratum corneum. CONCLUSIONS: This work encourages further investigation of DPCP absorption using NLCs with a specific formulation design. More... »
PAGES435-446
http://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0
DOIhttp://dx.doi.org/10.1007/s11095-012-0888-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1052368670
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23070602
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Other Physical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alopecia Areata",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclopropanes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Delayed-Action Preparations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Delivery Systems",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hair Follicle",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Keratinocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Nude",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nanostructures",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Particle Size",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphatidylcholines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Skin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Skin Absorption",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Squalene",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Surface-Active Agents",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Keelung Chang Gung Memorial Hospital",
"id": "https://www.grid.ac/institutes/grid.454209.e",
"name": [
"School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan",
"Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan"
],
"type": "Organization"
},
"familyName": "Lin",
"givenName": "Yin-Ku",
"id": "sg:person.01364467140.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364467140.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "King Saud University",
"id": "https://www.grid.ac/institutes/grid.56302.32",
"name": [
"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"
],
"type": "Organization"
},
"familyName": "Al-Suwayeh",
"givenName": "Saleh A.",
"id": "sg:person.01275264624.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275264624.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chang Gung University",
"id": "https://www.grid.ac/institutes/grid.145695.a",
"name": [
"Natural Products Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan"
],
"type": "Organization"
},
"familyName": "Leu",
"givenName": "Yann-Lii",
"id": "sg:person.0666303106.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666303106.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chang Gung University",
"id": "https://www.grid.ac/institutes/grid.145695.a",
"name": [
"Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, 333, Kweishan, Taoyuan, Taiwan",
"Chinese Herbal Medicine Research Team Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan"
],
"type": "Organization"
},
"familyName": "Shen",
"givenName": "Feng-Ming",
"id": "sg:person.01106253124.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106253124.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chang Gung University of Science and Technology",
"id": "https://www.grid.ac/institutes/grid.418428.3",
"name": [
"Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, 333, Kweishan, Taoyuan, Taiwan",
"Department of Cosmetic Science, Chang Gung University of Science & Technology, Kweishan, Taoyuan, Taiwan"
],
"type": "Organization"
},
"familyName": "Fang",
"givenName": "Jia-You",
"id": "sg:person.0617150155.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617150155.43"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0939-6411(01)00167-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000657666"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2125.2009.03463.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001296560"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2125.2009.03463.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001296560"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1046/j.0022-202x.2003.22110.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001868404",
"https://doi.org/10.1046/j.0022-202x.2003.22110.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2008.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002143977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/0957-4484/23/9/095103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003175690"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-3083.2009.03401.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003513992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-3083.2009.03401.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003513992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2005.09.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004248920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2005.09.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004248920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1468-3083.2007.02411.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004723691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2009.01.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006571613"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.0022-202x.2005.23779.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007201964",
"https://doi.org/10.1111/j.0022-202x.2005.23779.x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/0957-4484/21/40/405101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007942131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1117/1.3080714",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009067976"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1117/1.3080714",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009067976"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archderm.138.1.112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010399405"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2007.07.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011064894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/02652040902746679",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012909445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2010/171265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014401150"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2010/171265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014401150"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/08923970903440200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014465910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.addr.2007.04.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015785001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-5173(01)00824-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019186435"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.jid.5700733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019494250",
"https://doi.org/10.1038/sj.jid.5700733"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejps.2005.10.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019758822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/ijn.s29369",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022514577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejps.2006.11.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025841742"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2133.2003.05535.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028883657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.22741",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029430209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.22271",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030010282"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/toxsci/kfp139",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030713457"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2005.09.052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033288437"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000131080",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037617701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2008.08.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038058983"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejps.2009.06.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038060511"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/09687688.2010.522203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038738063"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2011.04.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042447286"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00118-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042798133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0169-409x(02)00118-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042798133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jaad.2009.10.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047580272"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-06-2354",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048448200"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2008.10.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048627630"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-009-0053-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050615236",
"https://doi.org/10.1007/s00018-009-0053-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-009-0053-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050615236",
"https://doi.org/10.1007/s00018-009-0053-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-009-0053-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050615236",
"https://doi.org/10.1007/s00018-009-0053-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.21817",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051312441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2004.03.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052086040"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074860765",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077322160",
"type": "CreativeWork"
}
],
"datePublished": "2013-02",
"datePublishedReg": "2013-02-01",
"description": "PURPOSE: Diphencyprone (DPCP) is a therapeutic agent for treating alopecia areata. To improve skin absorption and follicular targeting nanostructured lipid carriers (NLCs) were developed.\nMETHODS: Nanoparticles were characterized by size, zeta potential, molecular environment, differential scanning calorimetry (DSC), and nuclear magnetic resonance (NMR). In vitro and in vivo skin absorption experiments were performed. Fluorescence and confocal microscopes for imaging skin distribution were used.\nRESULTS: NLCs with different designs were 208\u2009~\u2009265\u00a0nm with \u2009>\u200977% DPCP encapsulation. NLCs incorporating a cationic surfactant or more soybean phosphatidylcholine (SPC) showed higher lipophilicity compared to typical NLCs by Nile red emission. All NLCs tested revealed controlled DPCP release; burst release was observed for control. The formulation with more SPC provided 275\u00a0\u03bcg/g DPCP skin retention, which was greater than control and other NLCs. Intersubject deviation was reduced after DPCP loading into NLCs. Cyanoacrylate skin biopsy demonstrated greater follicular deposition for NLCs with more SPC compared to control. Cationic NLCs but not typical or SPC-containing carriers were largely internalized into keratinocytes. In vivo skin retention of NLCs with more SPC was higher than free control. Confocal imaging confirmed localization of NLCs in follicles and intercellular lipids of stratum corneum.\nCONCLUSIONS: This work encourages further investigation of DPCP absorption using NLCs with a specific formulation design.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11095-012-0888-0",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1094644",
"issn": [
"0724-8741",
"1573-904X"
],
"name": "Pharmaceutical Research",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "30"
}
],
"name": "Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata",
"pagination": "435-446",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"f972e8815412ace20c710fb58c7981ac5804503de51117fd95a14846bfb558f7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23070602"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8406521"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11095-012-0888-0"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1052368670"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11095-012-0888-0",
"https://app.dimensions.ai/details/publication/pub.1052368670"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T23:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000524.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11095-012-0888-0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-012-0888-0'
This table displays all metadata directly associated to this object as RDF triples.
306 TRIPLES
21 PREDICATES
88 URIs
38 LITERALS
26 BLANK NODES