Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-15

AUTHORS

Dhrumil Upadhyay, Santo Scalia, Robert Vogel, Nial Wheate, Rania O. Salama, Paul M. Young, Daniela Traini, Wojciech Chrzanowski

ABSTRACT

ABSTRACTPurposeConditions such as lung cancer currently lack non-invasively targetable and controlled release topical inhalational therapies. Superparamagnetic iron-oxide nanoparticles (SPIONs) have shown promising results as a targetable therapy. We aimed to fabricate and test the in-vitro performance of particles with SPION and drug within a lipid matrix as a potentially targetable and thermo-sensitive inhalable drug-delivery system.MethodsBudesonide and SPIONs were incorporated into lipid particles using oil-in-water emulsification. Particles size, chemical composition, responsiveness to magnetic field, thermosensitiveness and inhalation performance in-vitro were investigated.ResultsParticles of average diameter 2–4 μm with budesonide and SPIONs inside the lipid matrix responded to a magnetic field with 100% extraction at a distance of 5 mm. Formulations were shown to have accelerated rate of drug release at hyperthermic temperatures (45°C)—controlled release. The produced inhalation dry powder presented promising inhalation performance, with an inhalable fine particle fraction of 30%.ConclusionsThe lipid system presented thermo-sensitive characteristics, suitable for controlled delivery, the model drug and SPION loaded lipid system was magnetically active and movable using simple permanent magnets, and the system demonstrates promise as an effective drug vehicle in targeted and controlled inhalation therapy. More... »

PAGES

2456-2467

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-012-0774-9

DOI

http://dx.doi.org/10.1007/s11095-012-0774-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046027899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22584949


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