Intratracheal Versus Intravenous Liposomal Delivery of siRNA, Antisense Oligonucleotides and Anticancer Drug View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

Olga B. Garbuzenko, Maha Saad, Seema Betigeri, Min Zhang, Alexandre A. Vetcher, Viatcheslav A. Soldatenkov, David C. Reimer, Vitaly P. Pozharov, Tamara Minko

ABSTRACT

PURPOSE: To compare systemic intravenous and local intratracheal delivery of doxorubicin (DOX), antisense oligonucleotides (ASO) and small interfering RNA (siRNA). METHODS: "Neutral" and cationic liposomes were used to deliver DOX, ASO, and siRNA. Liposomes were characterized by dynamic light scattering, zeta-potential, and atomic force microscopy. Cellular internalization of DOX, ASO and siRNA was studied by confocal microscopy on human lung carcinoma cells. In vivo experiments were carried out on nude mice with an orthotopic model of human lung cancer. RESULTS: Liposomes provided for an efficient intracellular delivery of DOX, ASO, and siRNA in vitro. Intratracheal delivery of both types of liposomes in vivo led to higher peak concentrations and much longer retention of liposomes, DOX, ASO and siRNA in the lungs when compared with systemic administration. It was found that local intratracheal treatment of lung cancer with liposomal DOX was more efficient when compared with free and liposomal DOX delivered intravenously. CONCLUSIONS: The present study outlined the clear advantages of local intratracheal delivery of liposomal drugs for the treatment of lung cancer when compared with systemic administration of the same drug. More... »

PAGES

382

Journal

TITLE

Pharmaceutical Research

ISSUE

2

VOLUME

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-008-9755-4

DOI

http://dx.doi.org/10.1007/s11095-008-9755-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039955934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18958402


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