Application of Micro- and Nano-Electromechanical Devices to Drug Delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

Mark Staples, Karen Daniel, Michael J. Cima, Robert Langer

ABSTRACT

Micro- and nano-electromechanical systems (MEMS and NEMS)-based drug delivery devices have become commercially-feasible due to converging technologies and regulatory accommodation. The FDA Office of Combination Products coordinates review of innovative medical therapies that join elements from multiple established categories: drugs, devices, and biologics. Combination products constructed using MEMS or NEMS technology offer revolutionary opportunities to address unmet medical needs related to dosing. These products have the potential to completely control drug release, meeting requirements for on-demand pulsatile or adjustable continuous administration for extended periods. MEMS or NEMS technologies, materials science, data management, and biological science have all significantly developed in recent years, providing a multidisciplinary foundation for developing integrated therapeutic systems. If small-scale biosensor and drug reservoir units are combined and implanted, a wireless integrated system can regulate drug release, receive sensor feedback, and transmit updates. For example, an "artificial pancreas" implementation of an integrated therapeutic system would improve diabetes management. The tools of microfabrication technology, information science, and systems biology are being combined to design increasingly sophisticated drug delivery systems that promise to significantly improve medical care. More... »

PAGES

847-863

References to SciGraph publications

  • 2003-01. Microfabricated Porous Silicon Particles Enhance Paracellular Delivery of Insulin Across Intestinal Caco-2 Cell Monolayers in PHARMACEUTICAL RESEARCH
  • 1999-01. Artificial Neural Network as a Novel Method to Optimize Pharmaceutical Formulations in PHARMACEUTICAL RESEARCH
  • 2004-12. A Novel Preformulation Tool to Group Microcrystalline Celluloses Using Artificial Neural Network and Data Clustering in PHARMACEUTICAL RESEARCH
  • 2005-12. Artificial neural networks for diagnosis and survival prediction in colon cancer in MOLECULAR CANCER
  • 2003-11. Multi-pulse drug delivery from a resorbable polymeric microchip device in NATURE MATERIALS
  • 1999-01. A controlled-release microchip in NATURE
  • 2004-06. Transdermal Delivery of Insulin Using Microneedles in Vivo in PHARMACEUTICAL RESEARCH
  • 2001-06. Bioadhesive Microdevices for Drug Delivery: A Feasibility Study in BIOMEDICAL MICRODEVICES
  • 1991-10. Application of Neural Computing in Pharmaceutical Product Development in PHARMACEUTICAL RESEARCH
  • 2003-08. Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism in NATURE REVIEWS DRUG DISCOVERY
  • 2001-06. Microfabricated Drug Delivery Systems: Concepts to Improve Clinical Benefit in BIOMEDICAL MICRODEVICES
  • 2003-10. Small-scale systems for in vivo drug delivery in NATURE BIOTECHNOLOGY
  • 2003-03. Synthesis and size-dependent properties of zinc-blende semiconductor quantum rods in NATURE MATERIALS
  • 2006-04. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11095-006-9906-4

    DOI

    http://dx.doi.org/10.1007/s11095-006-9906-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042129015

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16715375


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biomedical Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Cutaneous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Delayed-Action Preparations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Delivery Systems", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Implants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electronics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Equipment Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infusion Pumps, Implantable", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nanotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Technology, Pharmaceutical", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Microchips Biotech (United States)", 
              "id": "https://www.grid.ac/institutes/grid.429546.8", 
              "name": [
                "MicroCHIPS, Inc., 6-B Preston Court, 01730, Bedford, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Staples", 
            "givenName": "Mark", 
            "id": "sg:person.01350472337.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350472337.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daniel", 
            "givenName": "Karen", 
            "id": "sg:person.0660037677.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660037677.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cima", 
            "givenName": "Michael J.", 
            "id": "sg:person.01307523563.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307523563.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langer", 
            "givenName": "Robert", 
            "id": "sg:person.01117537642.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117537642.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.jconrel.2005.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002405345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1015843527138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002628904", 
              "https://doi.org/10.1023/a:1015843527138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1101398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003587490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2331316100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004630788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5173(94)90147-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004655881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-5173(94)90147-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004655881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-0286(02)00032-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005720612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1201/9780203910337.ch42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007215991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.snb.2004.06.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007617284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011986823850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007767460", 
              "https://doi.org/10.1023/a:1011986823850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sna.2004.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008203288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000050367.65079.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008894182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2004.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009842046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010256887", 
              "https://doi.org/10.1038/nmat830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010256887", 
              "https://doi.org/10.1038/nmat830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1163/1568562041959991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010671606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0957-4484/16/4/023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010706493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0960-1317/3/4/002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011078471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011442024658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012226529", 
              "https://doi.org/10.1023/a:1011442024658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022211127890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012380487", 
              "https://doi.org/10.1023/a:1022211127890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014496215", 
              "https://doi.org/10.1038/nmat998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmat998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014496215", 
              "https://doi.org/10.1038/nmat998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/bio-120020169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015147351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015601292", 
              "https://doi.org/10.1038/nbt1199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015601292", 
              "https://doi.org/10.1038/nbt1199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bp049976w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015912540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-4-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016036854", 
              "https://doi.org/10.1186/1476-4598-4-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016622853", 
              "https://doi.org/10.1038/16898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016622853", 
              "https://doi.org/10.1038/16898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2003.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018099373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11095-004-7690-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021977502", 
              "https://doi.org/10.1007/s11095-004-7690-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/aic.10489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023153582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1201/9780203910337.ch55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024536443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0960-1317/4/4/001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027147727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1011489907820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027690163", 
              "https://doi.org/10.1023/a:1011489907820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1201/9780203910337.pt6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028691536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jps.2600720307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029796925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2004.09.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030776331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/03639049509048099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031632520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031651380", 
              "https://doi.org/10.1038/nbt876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031651380", 
              "https://doi.org/10.1038/nbt876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.1999.7175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032966124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033419686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2005.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033419686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0731-7085(99)00272-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034030056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(03)00005-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034307702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(03)00005-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034307702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-3773(20000717)39:14<2396::aid-anie2396>3.0.co;2-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035079577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(02)00227-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035395953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-409x(02)00227-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035395953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0924-4247(01)00680-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035981533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.30019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038362246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/js980085q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038513174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiomech.2003.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039507975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.152463399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039713086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1201/9780203910337.pt5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040148810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0022-3727/38/5/015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041298917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.addr.2003.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041397309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0376-7388(99)00062-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042355027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sna.2004.06.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043110203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(02)00074-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044567797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.2000.7311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046089439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2005.09.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046130333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.snb.2004.04.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046551926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.snb.2004.04.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046551926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047074286", 
              "https://doi.org/10.1038/nrd1157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047074286", 
              "https://doi.org/10.1038/nrd1157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpa.2004.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050122140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:pham.0000029282.44140.2e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050296305", 
              "https://doi.org/10.1023/b:pham.0000029282.44140.2e"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-5173(98)00099-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050355628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1063/1.1345830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057697190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/dia.2005.7.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059248733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/84.679390", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061240636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jmems.2003.809959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061289769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jmems.2003.818070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061289820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jmems.2003.820293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061289849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jmems.2005.844843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061290031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jmems.2005.844843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061290031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jproc.2003.820534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061296201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/jproc.2003.820542", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061296205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/proc.1982.12331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061444988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/proc.1982.12331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061444988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/proc.1982.12331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061444988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/proc.1982.12331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1061444988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6776628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062640201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1566524053152898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069185665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diab.34.4.353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070734789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075168609", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075202796", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-05", 
        "datePublishedReg": "2006-05-01", 
        "description": "Micro- and nano-electromechanical systems (MEMS and NEMS)-based drug delivery devices have become commercially-feasible due to converging technologies and regulatory accommodation. The FDA Office of Combination Products coordinates review of innovative medical therapies that join elements from multiple established categories: drugs, devices, and biologics. Combination products constructed using MEMS or NEMS technology offer revolutionary opportunities to address unmet medical needs related to dosing. These products have the potential to completely control drug release, meeting requirements for on-demand pulsatile or adjustable continuous administration for extended periods. MEMS or NEMS technologies, materials science, data management, and biological science have all significantly developed in recent years, providing a multidisciplinary foundation for developing integrated therapeutic systems. If small-scale biosensor and drug reservoir units are combined and implanted, a wireless integrated system can regulate drug release, receive sensor feedback, and transmit updates. For example, an \"artificial pancreas\" implementation of an integrated therapeutic system would improve diabetes management. The tools of microfabrication technology, information science, and systems biology are being combined to design increasingly sophisticated drug delivery systems that promise to significantly improve medical care.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11095-006-9906-4", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094644", 
            "issn": [
              "0724-8741", 
              "1573-904X"
            ], 
            "name": "Pharmaceutical Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "name": "Application of Micro- and Nano-Electromechanical Devices to Drug Delivery", 
        "pagination": "847-863", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c8ae6fdaf678040756ee216cda7d33a803d096265f82b0cf0dc394ad15dcd2fa"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16715375"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8406521"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11095-006-9906-4"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1042129015"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11095-006-9906-4", 
          "https://app.dimensions.ai/details/publication/pub.1042129015"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T02:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000523.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11095-006-9906-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9906-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9906-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9906-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9906-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    376 TRIPLES      21 PREDICATES      115 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11095-006-9906-4 schema:about N2d55c926a4d8440f84450d24d77140ef
    2 N2ecfbe97f2824ad2a51fb99722e0c588
    3 N2f6145ae6e8743e9817ec0e132eab023
    4 N439fade1b01e484abc243f49449fa2bc
    5 N468411c959ff4fa38913e0b7a720b48b
    6 N6888af21e8514d75a21b17fac8d3b378
    7 N7c608f8221e647e399bf5b1d488bcdc9
    8 N96532aa52c8e4811868125c2934f2e19
    9 N9eda1bf190164bf2828f9cf33cab4696
    10 Ncf8d4c13642a4f8ea0e54f8eccdd2ed7
    11 Nd6c930d94e9948a893d127255ceb9d24
    12 Nfe21e3f395444e76a9deaa7799104332
    13 anzsrc-for:09
    14 anzsrc-for:0903
    15 schema:author Ne2a4b1e4e748493bbdc57ab54dc96510
    16 schema:citation sg:pub.10.1007/s11095-004-7690-6
    17 sg:pub.10.1023/a:1011442024658
    18 sg:pub.10.1023/a:1011489907820
    19 sg:pub.10.1023/a:1011986823850
    20 sg:pub.10.1023/a:1015843527138
    21 sg:pub.10.1023/a:1022211127890
    22 sg:pub.10.1023/b:pham.0000029282.44140.2e
    23 sg:pub.10.1038/16898
    24 sg:pub.10.1038/nbt1199
    25 sg:pub.10.1038/nbt876
    26 sg:pub.10.1038/nmat830
    27 sg:pub.10.1038/nmat998
    28 sg:pub.10.1038/nrd1157
    29 sg:pub.10.1186/1476-4598-4-29
    30 https://app.dimensions.ai/details/publication/pub.1075168609
    31 https://app.dimensions.ai/details/publication/pub.1075202796
    32 https://doi.org/10.1002/1521-3773(20000717)39:14<2396::aid-anie2396>3.0.co;2-u
    33 https://doi.org/10.1002/aic.10489
    34 https://doi.org/10.1002/jbm.a.30019
    35 https://doi.org/10.1002/jps.2600720307
    36 https://doi.org/10.1006/exnr.1999.7175
    37 https://doi.org/10.1006/exnr.2000.7311
    38 https://doi.org/10.1016/0378-5173(94)90147-3
    39 https://doi.org/10.1016/j.addr.2003.07.012
    40 https://doi.org/10.1016/j.addr.2003.09.001
    41 https://doi.org/10.1016/j.cbpa.2004.12.004
    42 https://doi.org/10.1016/j.jbiomech.2003.12.010
    43 https://doi.org/10.1016/j.jconrel.2004.08.018
    44 https://doi.org/10.1016/j.jconrel.2004.09.024
    45 https://doi.org/10.1016/j.jconrel.2005.04.009
    46 https://doi.org/10.1016/j.jconrel.2005.09.019
    47 https://doi.org/10.1016/j.jconrel.2005.09.035
    48 https://doi.org/10.1016/j.sna.2004.06.025
    49 https://doi.org/10.1016/j.sna.2004.11.004
    50 https://doi.org/10.1016/j.snb.2004.04.081
    51 https://doi.org/10.1016/j.snb.2004.06.035
    52 https://doi.org/10.1016/s0168-3659(02)00074-3
    53 https://doi.org/10.1016/s0168-3659(03)00005-1
    54 https://doi.org/10.1016/s0169-409x(02)00227-2
    55 https://doi.org/10.1016/s0376-7388(99)00062-9
    56 https://doi.org/10.1016/s0378-5173(98)00099-4
    57 https://doi.org/10.1016/s0731-7085(99)00272-1
    58 https://doi.org/10.1016/s0924-4247(01)00680-x
    59 https://doi.org/10.1016/s1359-0286(02)00032-3
    60 https://doi.org/10.1021/bp049976w
    61 https://doi.org/10.1021/js980085q
    62 https://doi.org/10.1063/1.1345830
    63 https://doi.org/10.1073/pnas.152463399
    64 https://doi.org/10.1073/pnas.2331316100
    65 https://doi.org/10.1081/bio-120020169
    66 https://doi.org/10.1088/0022-3727/38/5/015
    67 https://doi.org/10.1088/0957-4484/16/4/023
    68 https://doi.org/10.1088/0960-1317/3/4/002
    69 https://doi.org/10.1088/0960-1317/4/4/001
    70 https://doi.org/10.1089/dia.2005.7.28
    71 https://doi.org/10.1109/84.679390
    72 https://doi.org/10.1109/jmems.2003.809959
    73 https://doi.org/10.1109/jmems.2003.818070
    74 https://doi.org/10.1109/jmems.2003.820293
    75 https://doi.org/10.1109/jmems.2005.844843
    76 https://doi.org/10.1109/jproc.2003.820534
    77 https://doi.org/10.1109/jproc.2003.820542
    78 https://doi.org/10.1109/proc.1982.12331
    79 https://doi.org/10.1126/science.1101398
    80 https://doi.org/10.1126/science.6776628
    81 https://doi.org/10.1161/01.cir.0000050367.65079.71
    82 https://doi.org/10.1163/1568562041959991
    83 https://doi.org/10.1201/9780203910337.ch42
    84 https://doi.org/10.1201/9780203910337.ch55
    85 https://doi.org/10.1201/9780203910337.pt5
    86 https://doi.org/10.1201/9780203910337.pt6
    87 https://doi.org/10.2174/1566524053152898
    88 https://doi.org/10.2337/diab.34.4.353
    89 https://doi.org/10.3109/03639049509048099
    90 schema:datePublished 2006-05
    91 schema:datePublishedReg 2006-05-01
    92 schema:description Micro- and nano-electromechanical systems (MEMS and NEMS)-based drug delivery devices have become commercially-feasible due to converging technologies and regulatory accommodation. The FDA Office of Combination Products coordinates review of innovative medical therapies that join elements from multiple established categories: drugs, devices, and biologics. Combination products constructed using MEMS or NEMS technology offer revolutionary opportunities to address unmet medical needs related to dosing. These products have the potential to completely control drug release, meeting requirements for on-demand pulsatile or adjustable continuous administration for extended periods. MEMS or NEMS technologies, materials science, data management, and biological science have all significantly developed in recent years, providing a multidisciplinary foundation for developing integrated therapeutic systems. If small-scale biosensor and drug reservoir units are combined and implanted, a wireless integrated system can regulate drug release, receive sensor feedback, and transmit updates. For example, an "artificial pancreas" implementation of an integrated therapeutic system would improve diabetes management. The tools of microfabrication technology, information science, and systems biology are being combined to design increasingly sophisticated drug delivery systems that promise to significantly improve medical care.
    93 schema:genre research_article
    94 schema:inLanguage en
    95 schema:isAccessibleForFree false
    96 schema:isPartOf N9f1a3b82679f420499cdea88f12e3ebc
    97 Ne46c589e1f14423593c28603396bfdf9
    98 sg:journal.1094644
    99 schema:name Application of Micro- and Nano-Electromechanical Devices to Drug Delivery
    100 schema:pagination 847-863
    101 schema:productId N3204c63900724a6194a130ae1cf46d16
    102 N5a8953e6ba6b4d8facd0ebd4cb6af7b8
    103 N72d50cf4741944c29fdd7a6619521d6e
    104 Nc64f58e5e01d4971961a2a27650f5102
    105 Ncd18a5af6c8c4e63a3da19d51623df3d
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042129015
    107 https://doi.org/10.1007/s11095-006-9906-4
    108 schema:sdDatePublished 2019-04-11T02:11
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher N6b9c0662b49141c6a207b4af7ac73d24
    111 schema:url http://link.springer.com/10.1007%2Fs11095-006-9906-4
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N1e30291042024d3da68e0a1b0f337c2f rdf:first sg:person.0660037677.23
    116 rdf:rest N51d7cbbf02ee4e169003e2bfb16d964c
    117 N2d55c926a4d8440f84450d24d77140ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Drug Delivery Systems
    119 rdf:type schema:DefinedTerm
    120 N2ecfbe97f2824ad2a51fb99722e0c588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Delayed-Action Preparations
    122 rdf:type schema:DefinedTerm
    123 N2f6145ae6e8743e9817ec0e132eab023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Equipment Design
    125 rdf:type schema:DefinedTerm
    126 N3204c63900724a6194a130ae1cf46d16 schema:name doi
    127 schema:value 10.1007/s11095-006-9906-4
    128 rdf:type schema:PropertyValue
    129 N439c90320d4949a5af7a3c8715c13981 rdf:first sg:person.01117537642.02
    130 rdf:rest rdf:nil
    131 N439fade1b01e484abc243f49449fa2bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Drug Implants
    133 rdf:type schema:DefinedTerm
    134 N468411c959ff4fa38913e0b7a720b48b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Electronics
    136 rdf:type schema:DefinedTerm
    137 N51d7cbbf02ee4e169003e2bfb16d964c rdf:first sg:person.01307523563.51
    138 rdf:rest N439c90320d4949a5af7a3c8715c13981
    139 N5a8953e6ba6b4d8facd0ebd4cb6af7b8 schema:name pubmed_id
    140 schema:value 16715375
    141 rdf:type schema:PropertyValue
    142 N6888af21e8514d75a21b17fac8d3b378 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Stents
    144 rdf:type schema:DefinedTerm
    145 N6b9c0662b49141c6a207b4af7ac73d24 schema:name Springer Nature - SN SciGraph project
    146 rdf:type schema:Organization
    147 N72d50cf4741944c29fdd7a6619521d6e schema:name readcube_id
    148 schema:value c8ae6fdaf678040756ee216cda7d33a803d096265f82b0cf0dc394ad15dcd2fa
    149 rdf:type schema:PropertyValue
    150 N7c608f8221e647e399bf5b1d488bcdc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Humans
    152 rdf:type schema:DefinedTerm
    153 N96532aa52c8e4811868125c2934f2e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Technology, Pharmaceutical
    155 rdf:type schema:DefinedTerm
    156 N9eda1bf190164bf2828f9cf33cab4696 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Administration, Cutaneous
    158 rdf:type schema:DefinedTerm
    159 N9f1a3b82679f420499cdea88f12e3ebc schema:issueNumber 5
    160 rdf:type schema:PublicationIssue
    161 Nc64f58e5e01d4971961a2a27650f5102 schema:name dimensions_id
    162 schema:value pub.1042129015
    163 rdf:type schema:PropertyValue
    164 Ncd18a5af6c8c4e63a3da19d51623df3d schema:name nlm_unique_id
    165 schema:value 8406521
    166 rdf:type schema:PropertyValue
    167 Ncf8d4c13642a4f8ea0e54f8eccdd2ed7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Nanotechnology
    169 rdf:type schema:DefinedTerm
    170 Nd6c930d94e9948a893d127255ceb9d24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Animals
    172 rdf:type schema:DefinedTerm
    173 Ne2a4b1e4e748493bbdc57ab54dc96510 rdf:first sg:person.01350472337.19
    174 rdf:rest N1e30291042024d3da68e0a1b0f337c2f
    175 Ne46c589e1f14423593c28603396bfdf9 schema:volumeNumber 23
    176 rdf:type schema:PublicationVolume
    177 Nfe21e3f395444e76a9deaa7799104332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Infusion Pumps, Implantable
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Engineering
    182 rdf:type schema:DefinedTerm
    183 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Biomedical Engineering
    185 rdf:type schema:DefinedTerm
    186 sg:journal.1094644 schema:issn 0724-8741
    187 1573-904X
    188 schema:name Pharmaceutical Research
    189 rdf:type schema:Periodical
    190 sg:person.01117537642.02 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    191 schema:familyName Langer
    192 schema:givenName Robert
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117537642.02
    194 rdf:type schema:Person
    195 sg:person.01307523563.51 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    196 schema:familyName Cima
    197 schema:givenName Michael J.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307523563.51
    199 rdf:type schema:Person
    200 sg:person.01350472337.19 schema:affiliation https://www.grid.ac/institutes/grid.429546.8
    201 schema:familyName Staples
    202 schema:givenName Mark
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350472337.19
    204 rdf:type schema:Person
    205 sg:person.0660037677.23 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    206 schema:familyName Daniel
    207 schema:givenName Karen
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660037677.23
    209 rdf:type schema:Person
    210 sg:pub.10.1007/s11095-004-7690-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021977502
    211 https://doi.org/10.1007/s11095-004-7690-6
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1023/a:1011442024658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012226529
    214 https://doi.org/10.1023/a:1011442024658
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1023/a:1011489907820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027690163
    217 https://doi.org/10.1023/a:1011489907820
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1023/a:1011986823850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007767460
    220 https://doi.org/10.1023/a:1011986823850
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1023/a:1015843527138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002628904
    223 https://doi.org/10.1023/a:1015843527138
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1023/a:1022211127890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012380487
    226 https://doi.org/10.1023/a:1022211127890
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1023/b:pham.0000029282.44140.2e schema:sameAs https://app.dimensions.ai/details/publication/pub.1050296305
    229 https://doi.org/10.1023/b:pham.0000029282.44140.2e
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/16898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016622853
    232 https://doi.org/10.1038/16898
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nbt1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015601292
    235 https://doi.org/10.1038/nbt1199
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nbt876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031651380
    238 https://doi.org/10.1038/nbt876
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nmat830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010256887
    241 https://doi.org/10.1038/nmat830
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nmat998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014496215
    244 https://doi.org/10.1038/nmat998
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nrd1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047074286
    247 https://doi.org/10.1038/nrd1157
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1186/1476-4598-4-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016036854
    250 https://doi.org/10.1186/1476-4598-4-29
    251 rdf:type schema:CreativeWork
    252 https://app.dimensions.ai/details/publication/pub.1075168609 schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1075202796 schema:CreativeWork
    254 https://doi.org/10.1002/1521-3773(20000717)39:14<2396::aid-anie2396>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1035079577
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1002/aic.10489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023153582
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1002/jbm.a.30019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038362246
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1002/jps.2600720307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029796925
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1006/exnr.1999.7175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032966124
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1006/exnr.2000.7311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046089439
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/0378-5173(94)90147-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004655881
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.addr.2003.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018099373
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.addr.2003.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041397309
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.cbpa.2004.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050122140
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.jbiomech.2003.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039507975
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.jconrel.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009842046
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.jconrel.2004.09.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030776331
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.jconrel.2005.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033419686
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.jconrel.2005.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405345
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.jconrel.2005.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046130333
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.sna.2004.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043110203
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.sna.2004.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008203288
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.snb.2004.04.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046551926
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.snb.2004.06.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007617284
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s0168-3659(02)00074-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044567797
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s0168-3659(03)00005-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034307702
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s0169-409x(02)00227-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035395953
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0376-7388(99)00062-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042355027
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0378-5173(98)00099-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050355628
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s0731-7085(99)00272-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034030056
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s0924-4247(01)00680-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035981533
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/s1359-0286(02)00032-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005720612
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1021/bp049976w schema:sameAs https://app.dimensions.ai/details/publication/pub.1015912540
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1021/js980085q schema:sameAs https://app.dimensions.ai/details/publication/pub.1038513174
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1063/1.1345830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057697190
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.152463399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039713086
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.2331316100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004630788
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1081/bio-120020169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015147351
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1088/0022-3727/38/5/015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041298917
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1088/0957-4484/16/4/023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010706493
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1088/0960-1317/3/4/002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011078471
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1088/0960-1317/4/4/001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027147727
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1089/dia.2005.7.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059248733
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1109/84.679390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061240636
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1109/jmems.2003.809959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061289769
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1109/jmems.2003.818070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061289820
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1109/jmems.2003.820293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061289849
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1109/jmems.2005.844843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061290031
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1109/jproc.2003.820534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061296201
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1109/jproc.2003.820542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061296205
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1109/proc.1982.12331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061444988
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1101398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003587490
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.6776628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062640201
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1161/01.cir.0000050367.65079.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008894182
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1163/1568562041959991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010671606
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1201/9780203910337.ch42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007215991
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1201/9780203910337.ch55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024536443
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1201/9780203910337.pt5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040148810
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1201/9780203910337.pt6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028691536
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.2174/1566524053152898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185665
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.2337/diab.34.4.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070734789
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.3109/03639049509048099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031632520
    369 rdf:type schema:CreativeWork
    370 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    371 schema:name Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    372 Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    373 rdf:type schema:Organization
    374 https://www.grid.ac/institutes/grid.429546.8 schema:alternateName Microchips Biotech (United States)
    375 schema:name MicroCHIPS, Inc., 6-B Preston Court, 01730, Bedford, Massachusetts, USA
    376 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...