Efficacy of siRNA Nanocapsules Targeted Against the EWS–Fli1 Oncogene in Ewing Sarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

Nedjma Toub, Jean-Rémi Bertrand, Ali Tamaddon, Hind Elhamess, Hervé Hillaireau, Andrei Maksimenko, Jean Maccario, Claude Malvy, Elias Fattal, Patrick Couvreur

ABSTRACT

The EWS-Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered to be the cause of the Ewing sarcoma. The efficiency of small interfering RNAs (siRNAs) targeted toward the EWS-Fli1 transcript (at the junction point type 1) was studied, free or encapsulated into recently developed polyisobutylcyanoacrylate aqueous core nanocapsules. Because this mRNA sequence is only present in cancer cells, it therefore constituted a relevant target. Studies of the intracellular penetration by confocal microscopy in NIH/3T3 EWS-Fli1 cells showed that nanocapsules improved the intracellular penetration of siRNA with mainly a cytoplasmic localization. These biodegradable siRNA-loaded nanocapsules were then tested in vivo on a mice xenografted EWS-Fli1-expressing tumor; they were found to trigger a dose-dependant inhibition of tumor growth after intratumoral injection. A specific inhibition of EWS-Fli1 was observed, too. These findings now open new prospects for the treatment of experimental cancers with junction oncogenes. More... »

PAGES

892-900

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-006-9901-9

DOI

http://dx.doi.org/10.1007/s11095-006-9901-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049317526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16715379


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyanoacrylates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NIH 3T3 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Protein c-fli-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Protein EWS", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma, Ewing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Facult\u00e9 de Pharmacie, UMR CNRS 8612, 92286, Ch\u00e2tenay-Malabry, France", 
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toub", 
        "givenName": "Nedjma", 
        "id": "sg:person.01345032777.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345032777.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bertrand", 
        "givenName": "Jean-R\u00e9mi", 
        "id": "sg:person.015756146402.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015756146402.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamaddon", 
        "givenName": "Ali", 
        "id": "sg:person.0667542077.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667542077.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elhamess", 
        "givenName": "Hind", 
        "id": "sg:person.01125773160.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125773160.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Facult\u00e9 de Pharmacie, UMR CNRS 8612, 92286, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hillaireau", 
        "givenName": "Herv\u00e9", 
        "id": "sg:person.01227521072.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227521072.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maksimenko", 
        "givenName": "Andrei", 
        "id": "sg:person.01340771606.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340771606.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Centre d' Etudes Pharmaceutiques, 12 roe J.B. Cl\u00e9ment, 92296, Chatenay-Malabry Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maccario", 
        "givenName": "Jean", 
        "id": "sg:person.0761332540.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761332540.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Laboratoire de Vecterologie et Transfert des G\u00e8nes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malvy", 
        "givenName": "Claude", 
        "id": "sg:person.01037610656.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037610656.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Facult\u00e9 de Pharmacie, UMR CNRS 8612, 92286, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fattal", 
        "givenName": "Elias", 
        "id": "sg:person.01146450602.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146450602.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Facult\u00e9 de Pharmacie, UMR CNRS 8612, 92286, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Couvreur", 
        "givenName": "Patrick", 
        "id": "sg:person.0760312615.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760312615.72"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000609560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(95)80016-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003314278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.23.6877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004775429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359162a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008302153", 
          "https://doi.org/10.1038/359162a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008836489", 
          "https://doi.org/10.1038/sj.onc.1206810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008836489", 
          "https://doi.org/10.1038/sj.onc.1206810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014854312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014937053", 
          "https://doi.org/10.1038/sj.cgt.7700831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014937053", 
          "https://doi.org/10.1038/sj.cgt.7700831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.14.5.3230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014950933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gnh140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015169514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.3963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017328614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018713804", 
          "https://doi.org/10.1038/35888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018713804", 
          "https://doi.org/10.1038/35888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.12.7393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019123032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1068999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020993705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372143a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027517345", 
          "https://doi.org/10.1038/372143a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1359.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029087499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1007582332491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032461777", 
          "https://doi.org/10.1023/a:1007582332491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2005.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033318641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2005.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033318641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418244a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887015", 
          "https://doi.org/10.1038/418244a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0502-446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036940895", 
          "https://doi.org/10.1038/nbt0502-446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0502-446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036940895", 
          "https://doi.org/10.1038/nbt0502-446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1996.0350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037275558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037720340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658253", 
          "https://doi.org/10.1038/35053110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658253", 
          "https://doi.org/10.1038/35053110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042953105", 
          "https://doi.org/10.1038/nm1174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042953105", 
          "https://doi.org/10.1038/nm1174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/97.9.627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044266648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1007574030674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046221871", 
          "https://doi.org/10.1023/a:1007574030674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046474258", 
          "https://doi.org/10.1038/bjc.1998.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046474258", 
          "https://doi.org/10.1038/bjc.1998.1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2004.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046573755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.12.5752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046742464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00440-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050197757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051365980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077734855", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082389646", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082395425", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082699818", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-05", 
    "datePublishedReg": "2006-05-01", 
    "description": "The EWS-Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered to be the cause of the Ewing sarcoma. The efficiency of small interfering RNAs (siRNAs) targeted toward the EWS-Fli1 transcript (at the junction point type 1) was studied, free or encapsulated into recently developed polyisobutylcyanoacrylate aqueous core nanocapsules. Because this mRNA sequence is only present in cancer cells, it therefore constituted a relevant target. Studies of the intracellular penetration by confocal microscopy in NIH/3T3 EWS-Fli1 cells showed that nanocapsules improved the intracellular penetration of siRNA with mainly a cytoplasmic localization. These biodegradable siRNA-loaded nanocapsules were then tested in vivo on a mice xenografted EWS-Fli1-expressing tumor; they were found to trigger a dose-dependant inhibition of tumor growth after intratumoral injection. A specific inhibition of EWS-Fli1 was observed, too. These findings now open new prospects for the treatment of experimental cancers with junction oncogenes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11095-006-9901-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "name": "Efficacy of siRNA Nanocapsules Targeted Against the EWS\u2013Fli1 Oncogene in Ewing Sarcoma", 
    "pagination": "892-900", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "eaf08d0884d1685853ba1bc6af5f2e35197bde57b9531e3ec2b8b1f6d2718bec"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16715379"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11095-006-9901-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049317526"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11095-006-9901-9", 
      "https://app.dimensions.ai/details/publication/pub.1049317526"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11095-006-9901-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9901-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9901-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9901-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-006-9901-9'


 

This table displays all metadata directly associated to this object as RDF triples.

323 TRIPLES      21 PREDICATES      81 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11095-006-9901-9 schema:about N0007d12c448b4524a488a44c51dc4e58
2 N0218c26b67b04cc694cc8861a898ede9
3 N1a2ceef034da49d78930c348e73231b6
4 N2347e38a13b441fbbf350024afe05677
5 N2518cd45ccf042f284a18eb8df815e23
6 N2e982d8b7b3f4881bde02db80eb0e28f
7 N37030bd5b0434d48beb616385e38c600
8 N376d1bc53af344b78792b31d0e2e0995
9 N5d310c22d3f54c758abed8574d462a3b
10 N7d1b7945186944f3a9063efb70d50b41
11 N87d92326a62347ae878b261e4e106bfe
12 N9344e5b993474a2c837c77c29ed3043a
13 Na1f60478b0804574b198b429b5daebba
14 Nb2a559ac67e748c2b4d83762fdfd75cc
15 Nb3e986248b3147f38237a0ccb413722b
16 Neac31da3672d4231b3ccf52aa0553f11
17 Nf442306963f641709e0939444a4c6683
18 Nf9466b32eb2b4ee2906db92af6756bb0
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N9e24d990527740abb818f4de96a89f13
22 schema:citation sg:pub.10.1023/a:1007574030674
23 sg:pub.10.1023/a:1007582332491
24 sg:pub.10.1038/35053110
25 sg:pub.10.1038/35888
26 sg:pub.10.1038/359162a0
27 sg:pub.10.1038/372143a0
28 sg:pub.10.1038/418244a
29 sg:pub.10.1038/bjc.1998.1
30 sg:pub.10.1038/nbt0502-446
31 sg:pub.10.1038/nm1174
32 sg:pub.10.1038/sj.cgt.7700831
33 sg:pub.10.1038/sj.onc.1206810
34 https://app.dimensions.ai/details/publication/pub.1077734855
35 https://app.dimensions.ai/details/publication/pub.1082389646
36 https://app.dimensions.ai/details/publication/pub.1082395425
37 https://app.dimensions.ai/details/publication/pub.1082699818
38 https://doi.org/10.1002/jgm.659
39 https://doi.org/10.1006/abio.1996.0350
40 https://doi.org/10.1006/bbrc.2000.3963
41 https://doi.org/10.1016/0005-2736(95)80016-9
42 https://doi.org/10.1016/j.chembiol.2004.06.006
43 https://doi.org/10.1016/j.pharmthera.2005.03.004
44 https://doi.org/10.1016/s1097-2765(02)00440-9
45 https://doi.org/10.1073/pnas.90.12.5752
46 https://doi.org/10.1093/emboj/20.23.6877
47 https://doi.org/10.1093/jnci/97.9.627
48 https://doi.org/10.1093/nar/gnh140
49 https://doi.org/10.1126/science.1068999
50 https://doi.org/10.1128/mcb.13.12.7393
51 https://doi.org/10.1128/mcb.14.5.3230
52 https://doi.org/10.1158/1078-0432.ccr-03-0740
53 https://doi.org/10.1158/1078-0432.ccr-04-1206
54 https://doi.org/10.1172/jci119152
55 https://doi.org/10.1196/annals.1359.010
56 schema:datePublished 2006-05
57 schema:datePublishedReg 2006-05-01
58 schema:description The EWS-Fli1 fusion gene encodes for a chimeric oncogenic transcription factor considered to be the cause of the Ewing sarcoma. The efficiency of small interfering RNAs (siRNAs) targeted toward the EWS-Fli1 transcript (at the junction point type 1) was studied, free or encapsulated into recently developed polyisobutylcyanoacrylate aqueous core nanocapsules. Because this mRNA sequence is only present in cancer cells, it therefore constituted a relevant target. Studies of the intracellular penetration by confocal microscopy in NIH/3T3 EWS-Fli1 cells showed that nanocapsules improved the intracellular penetration of siRNA with mainly a cytoplasmic localization. These biodegradable siRNA-loaded nanocapsules were then tested in vivo on a mice xenografted EWS-Fli1-expressing tumor; they were found to trigger a dose-dependant inhibition of tumor growth after intratumoral injection. A specific inhibition of EWS-Fli1 was observed, too. These findings now open new prospects for the treatment of experimental cancers with junction oncogenes.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N251fbe460d174bb29facf00a42532903
63 N42edc512a64147a184d71e06c6fa3daa
64 sg:journal.1094644
65 schema:name Efficacy of siRNA Nanocapsules Targeted Against the EWS–Fli1 Oncogene in Ewing Sarcoma
66 schema:pagination 892-900
67 schema:productId N08aa9ce8da634303aba6becbbb8a2d1c
68 N0cc956f4b3e44d169cba36dd8d9e2c05
69 N895aed847db54aceab9bc97ac1780be2
70 Nbd4452fb6a094f758958d2ee10aa2032
71 Nceaac53f206e43369e84da30018dfc80
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049317526
73 https://doi.org/10.1007/s11095-006-9901-9
74 schema:sdDatePublished 2019-04-10T13:20
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nc76ca07ac6234ad1925432a341c589ed
77 schema:url http://link.springer.com/10.1007%2Fs11095-006-9901-9
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0007d12c448b4524a488a44c51dc4e58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name RNA-Binding Protein EWS
83 rdf:type schema:DefinedTerm
84 N0218c26b67b04cc694cc8861a898ede9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Time Factors
86 rdf:type schema:DefinedTerm
87 N08aa9ce8da634303aba6becbbb8a2d1c schema:name nlm_unique_id
88 schema:value 8406521
89 rdf:type schema:PropertyValue
90 N0cc956f4b3e44d169cba36dd8d9e2c05 schema:name dimensions_id
91 schema:value pub.1049317526
92 rdf:type schema:PropertyValue
93 N156c9ee439ad4a85a8a7f33d050e3bb7 rdf:first sg:person.0760312615.72
94 rdf:rest rdf:nil
95 N1a2ceef034da49d78930c348e73231b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Sarcoma, Ewing
97 rdf:type schema:DefinedTerm
98 N2347e38a13b441fbbf350024afe05677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cyanoacrylates
100 rdf:type schema:DefinedTerm
101 N2518cd45ccf042f284a18eb8df815e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice, Nude
103 rdf:type schema:DefinedTerm
104 N251fbe460d174bb29facf00a42532903 schema:issueNumber 5
105 rdf:type schema:PublicationIssue
106 N2e982d8b7b3f4881bde02db80eb0e28f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Mice
108 rdf:type schema:DefinedTerm
109 N37030bd5b0434d48beb616385e38c600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name RNA, Small Interfering
111 rdf:type schema:DefinedTerm
112 N376d1bc53af344b78792b31d0e2e0995 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Nanotechnology
114 rdf:type schema:DefinedTerm
115 N42edc512a64147a184d71e06c6fa3daa schema:volumeNumber 23
116 rdf:type schema:PublicationVolume
117 N5158686cf08b4d2698936c2cdac21dd3 rdf:first sg:person.0667542077.32
118 rdf:rest Nd88e515da0a043029901dd9f3816c043
119 N5d310c22d3f54c758abed8574d462a3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name NIH 3T3 Cells
121 rdf:type schema:DefinedTerm
122 N6a03e5172fa34bbcbf34785fe34cf12d schema:name Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, UMR CNRS 8612, 92286, Châtenay-Malabry, France
123 rdf:type schema:Organization
124 N78cbf94fa8a44dfaab9d91656b3266cc rdf:first sg:person.0761332540.51
125 rdf:rest Nc3bff693b47045089df388ff0e5afdf5
126 N7d1b7945186944f3a9063efb70d50b41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Proto-Oncogene Protein c-fli-1
128 rdf:type schema:DefinedTerm
129 N84bde17debfc45eba7d90e3b4f523099 rdf:first sg:person.015756146402.41
130 rdf:rest N5158686cf08b4d2698936c2cdac21dd3
131 N87d92326a62347ae878b261e4e106bfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Fibroblasts
133 rdf:type schema:DefinedTerm
134 N895aed847db54aceab9bc97ac1780be2 schema:name doi
135 schema:value 10.1007/s11095-006-9901-9
136 rdf:type schema:PropertyValue
137 N9344e5b993474a2c837c77c29ed3043a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Nanoparticles
139 rdf:type schema:DefinedTerm
140 N99f883c6d2f04af5902cf1de9a6e2670 rdf:first sg:person.01340771606.27
141 rdf:rest N78cbf94fa8a44dfaab9d91656b3266cc
142 N9caa057b51ef4b90847321ab44b95a97 rdf:first sg:person.01227521072.35
143 rdf:rest N99f883c6d2f04af5902cf1de9a6e2670
144 N9e24d990527740abb818f4de96a89f13 rdf:first sg:person.01345032777.93
145 rdf:rest N84bde17debfc45eba7d90e3b4f523099
146 Na1f60478b0804574b198b429b5daebba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 Na6f6d874a23a4d73b7321bb8033a105a schema:name Centre d' Etudes Pharmaceutiques, 12 roe J.B. Clément, 92296, Chatenay-Malabry Cedex, France
150 rdf:type schema:Organization
151 Nae488645585f43a69283ac222e4a5a09 schema:name Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, UMR CNRS 8612, 92286, Châtenay-Malabry, France
152 rdf:type schema:Organization
153 Nb2a559ac67e748c2b4d83762fdfd75cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Oncogene Proteins, Fusion
155 rdf:type schema:DefinedTerm
156 Nb3e986248b3147f38237a0ccb413722b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name RNA, Messenger
158 rdf:type schema:DefinedTerm
159 Nbd4452fb6a094f758958d2ee10aa2032 schema:name readcube_id
160 schema:value eaf08d0884d1685853ba1bc6af5f2e35197bde57b9531e3ec2b8b1f6d2718bec
161 rdf:type schema:PropertyValue
162 Nc12cc49e3ad9498ba22f76318dd216e5 schema:name Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, UMR CNRS 8612, 92286, Châtenay-Malabry, France
163 rdf:type schema:Organization
164 Nc3bff693b47045089df388ff0e5afdf5 rdf:first sg:person.01037610656.22
165 rdf:rest Nce0393365b984d9eb00b9dc736b2bf40
166 Nc76ca07ac6234ad1925432a341c589ed schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 Nce0393365b984d9eb00b9dc736b2bf40 rdf:first sg:person.01146450602.87
169 rdf:rest N156c9ee439ad4a85a8a7f33d050e3bb7
170 Nceaac53f206e43369e84da30018dfc80 schema:name pubmed_id
171 schema:value 16715379
172 rdf:type schema:PropertyValue
173 Nd88e515da0a043029901dd9f3816c043 rdf:first sg:person.01125773160.02
174 rdf:rest N9caa057b51ef4b90847321ab44b95a97
175 Neac31da3672d4231b3ccf52aa0553f11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Transfection
177 rdf:type schema:DefinedTerm
178 Nf442306963f641709e0939444a4c6683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Polymers
180 rdf:type schema:DefinedTerm
181 Nf9466b32eb2b4ee2906db92af6756bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name RNA Interference
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
188 schema:name Oncology and Carcinogenesis
189 rdf:type schema:DefinedTerm
190 sg:journal.1094644 schema:issn 0724-8741
191 1573-904X
192 schema:name Pharmaceutical Research
193 rdf:type schema:Periodical
194 sg:person.01037610656.22 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
195 schema:familyName Malvy
196 schema:givenName Claude
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037610656.22
198 rdf:type schema:Person
199 sg:person.01125773160.02 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
200 schema:familyName Elhamess
201 schema:givenName Hind
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125773160.02
203 rdf:type schema:Person
204 sg:person.01146450602.87 schema:affiliation N6a03e5172fa34bbcbf34785fe34cf12d
205 schema:familyName Fattal
206 schema:givenName Elias
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146450602.87
208 rdf:type schema:Person
209 sg:person.01227521072.35 schema:affiliation Nae488645585f43a69283ac222e4a5a09
210 schema:familyName Hillaireau
211 schema:givenName Hervé
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227521072.35
213 rdf:type schema:Person
214 sg:person.01340771606.27 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
215 schema:familyName Maksimenko
216 schema:givenName Andrei
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340771606.27
218 rdf:type schema:Person
219 sg:person.01345032777.93 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
220 schema:familyName Toub
221 schema:givenName Nedjma
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345032777.93
223 rdf:type schema:Person
224 sg:person.015756146402.41 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
225 schema:familyName Bertrand
226 schema:givenName Jean-Rémi
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015756146402.41
228 rdf:type schema:Person
229 sg:person.0667542077.32 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
230 schema:familyName Tamaddon
231 schema:givenName Ali
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667542077.32
233 rdf:type schema:Person
234 sg:person.0760312615.72 schema:affiliation Nc12cc49e3ad9498ba22f76318dd216e5
235 schema:familyName Couvreur
236 schema:givenName Patrick
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760312615.72
238 rdf:type schema:Person
239 sg:person.0761332540.51 schema:affiliation Na6f6d874a23a4d73b7321bb8033a105a
240 schema:familyName Maccario
241 schema:givenName Jean
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761332540.51
243 rdf:type schema:Person
244 sg:pub.10.1023/a:1007574030674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046221871
245 https://doi.org/10.1023/a:1007574030674
246 rdf:type schema:CreativeWork
247 sg:pub.10.1023/a:1007582332491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032461777
248 https://doi.org/10.1023/a:1007582332491
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/35053110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042658253
251 https://doi.org/10.1038/35053110
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/35888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018713804
254 https://doi.org/10.1038/35888
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/359162a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008302153
257 https://doi.org/10.1038/359162a0
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/372143a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027517345
260 https://doi.org/10.1038/372143a0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/418244a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887015
263 https://doi.org/10.1038/418244a
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/bjc.1998.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046474258
266 https://doi.org/10.1038/bjc.1998.1
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nbt0502-446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036940895
269 https://doi.org/10.1038/nbt0502-446
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nm1174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042953105
272 https://doi.org/10.1038/nm1174
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/sj.cgt.7700831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014937053
275 https://doi.org/10.1038/sj.cgt.7700831
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/sj.onc.1206810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008836489
278 https://doi.org/10.1038/sj.onc.1206810
279 rdf:type schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1077734855 schema:CreativeWork
281 https://app.dimensions.ai/details/publication/pub.1082389646 schema:CreativeWork
282 https://app.dimensions.ai/details/publication/pub.1082395425 schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1082699818 schema:CreativeWork
284 https://doi.org/10.1002/jgm.659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051365980
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1006/abio.1996.0350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037275558
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1006/bbrc.2000.3963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017328614
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/0005-2736(95)80016-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003314278
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.chembiol.2004.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046573755
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.pharmthera.2005.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033318641
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/s1097-2765(02)00440-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050197757
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.90.12.5752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046742464
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/emboj/20.23.6877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004775429
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/jnci/97.9.627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044266648
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/nar/gnh140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015169514
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.1068999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020993705
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1128/mcb.13.12.7393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019123032
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/mcb.14.5.3230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014950933
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1158/1078-0432.ccr-03-0740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000609560
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1158/1078-0432.ccr-04-1206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037720340
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1172/jci119152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014854312
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1196/annals.1359.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029087499
319 rdf:type schema:CreativeWork
320 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
321 schema:name Laboratoire de Physicochimie, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, UMR CNRS 8612, 92286, Châtenay-Malabry, France
322 Laboratoire de Vecterologie et Transfert des Gènes, Institut Gustave Roussy, UMR CNRS 8121, 39, rue Camille Desmoulins, 94805, Villejuif Cedex, France
323 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...