Metabonomics Techniques and Applications to Pharmaceutical Research & Development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06

AUTHORS

John C. Lindon, Elaine Holmes, Jeremy K. Nicholson

ABSTRACT

In this review, the background to the approach known as metabonomics is provided, giving a brief historical perspective and summarizing the analytical and statistical techniques used. Some of the major applications of metabonomics relevant to pharmaceutical Research & Development are then reviewed including the study of various influences on metabolism, such as diet, lifestyle, and other environmental factors. The applications of metabonomics in drug safety studies are explained with special reference to the aims and achievements of the Consortium for Metabonomic Toxicology. Next, the role that metabonomics might have in disease diagnosis and therapy monitoring is provided with some examples, and the concept of pharmacometabonomics as a way of predicting an individual's response to treatment is highlighted. Some discussion is given on the strengths and weaknesses, opportunities of, and threats to metabonomics. More... »

PAGES

1075-1088

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-006-0025-z

DOI

http://dx.doi.org/10.1007/s11095-006-0025-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014267785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16715371


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