Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model of Inflammatory Pain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

Denis Projean, Sophie Dautrey, Huy Khan Vu, Thierry Groblewski, Jean-Louis Brazier, Julie Ducharme

ABSTRACT

PURPOSE: This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw. METHODS: Rats were humanely sacrificed at regular time points, plasma and liver samples were collected, liver mRNA extracted, and liver microsomes prepared. RESULTS: FCA injection led to the development of an acute inflammatory response evidenced by paw edema and increased alpha-1-acid glycoprotein (AGP) and total-nitrite (NOx) plasma concentrations. Plasma IL-6 levels were significantly higher in FCA-treated rats than in controls at 8 h post-FCA. Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1). CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged. CONCLUSIONS: These early biochemical and metabolic modifications may have pharmacokinetic and pharmacodynamic consequences when hepatically cleared drugs are administered to FCA-treated rats, especially within the first 24-72 h post-FCA. More... »

PAGES

62-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-004-9010-6

DOI

http://dx.doi.org/10.1007/s11095-004-9010-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005154680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15771231


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 Enzyme Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 Enzyme System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Freund's Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada", 
            "AstraZeneca R & D Montr\u00e9al, Information not available, Ville St-Laurent, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Projean", 
        "givenName": "Denis", 
        "id": "sg:person.0610325477.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610325477.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AstraZeneca R & D Montr\u00e9al, Information not available, Ville St-Laurent, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dautrey", 
        "givenName": "Sophie", 
        "id": "sg:person.01220401352.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220401352.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AstraZeneca R & D Montr\u00e9al, Information not available, Ville St-Laurent, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vu", 
        "givenName": "Huy Khan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AstraZeneca R & D Montr\u00e9al, Information not available, Ville St-Laurent, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groblewski", 
        "givenName": "Thierry", 
        "id": "sg:person.0755157500.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755157500.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brazier", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.01203232621.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203232621.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montreal", 
          "id": "https://www.grid.ac/institutes/grid.14848.31", 
          "name": [
            "Facult\u00e9 de Pharmacie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada", 
            "AstraZeneca R & D Montr\u00e9al, Information not available, Ville St-Laurent, Qu\u00e9bec, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ducharme", 
        "givenName": "Julie", 
        "id": "sg:person.01003273335.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003273335.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0167-4781(94)90074-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000221238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4781(94)90074-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000221238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2003.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004860096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1996.9752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006353765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1011915402914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007240519", 
          "https://doi.org/10.1023/a:1011915402914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(87)90291-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007746679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4347(01)00286-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009112751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(97)00063-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009697528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(03)01968-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011483641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.041582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012942029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2000.8532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013658506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-4165(02)00480-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015006562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-4165(02)00480-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015006562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00498259409038673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015582203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00498259409043263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016927046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(01)00165-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023957035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.02-0195fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027353228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(02)01423-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030319295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-0348-7775-6_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030877609", 
          "https://doi.org/10.1007/978-3-0348-7775-6_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.15.1.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033355295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-6147(99)01370-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037440324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0703486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039989275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35068566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040404719", 
          "https://doi.org/10.1038/35068566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35068566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040404719", 
          "https://doi.org/10.1038/35068566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.3219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040799347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0003-9861(02)00558-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042927649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-4274(97)00108-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042988035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(200006)43:6<1266::aid-anr9>3.0.co;2-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044571324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0703248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045071846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0701148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045214705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1996.0294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047990788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03602539709002246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048605762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1999.1496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050465932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199703)181:3<257::aid-path756>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051119492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076341235", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078954397", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404032", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.1994.267.6.r1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082518365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082883026", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082959712", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083060294", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083060296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.1997.272.3.r862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083066506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083326786", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083364770", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-01", 
    "datePublishedReg": "2005-01-01", 
    "description": "PURPOSE: This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw.\nMETHODS: Rats were humanely sacrificed at regular time points, plasma and liver samples were collected, liver mRNA extracted, and liver microsomes prepared.\nRESULTS: FCA injection led to the development of an acute inflammatory response evidenced by paw edema and increased alpha-1-acid glycoprotein (AGP) and total-nitrite (NOx) plasma concentrations. Plasma IL-6 levels were significantly higher in FCA-treated rats than in controls at 8 h post-FCA. Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1). CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged.\nCONCLUSIONS: These early biochemical and metabolic modifications may have pharmacokinetic and pharmacodynamic consequences when hepatically cleared drugs are administered to FCA-treated rats, especially within the first 24-72 h post-FCA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11095-004-9010-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model of Inflammatory Pain", 
    "pagination": "62-70", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "188f12aa7d74382529fea17200da35515da4337a9ba20c6324440c3a0d7122fc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15771231"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11095-004-9010-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005154680"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11095-004-9010-6", 
      "https://app.dimensions.ai/details/publication/pub.1005154680"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11095-004-9010-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-004-9010-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-004-9010-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-004-9010-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-004-9010-6'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      84 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11095-004-9010-6 schema:about N07fa1cbf02c14bad8b35b900e2100b74
2 N12012533c4604d7eb7ceb9e3d698ef03
3 N36f62079351041bebe68abb8d5619f71
4 N45f65e51773843d2bb972e988a5b1c95
5 N80e357f954d5484786597eb37e1aaf83
6 N9203f77b2a854622ac5ed83ef989747c
7 N95a36b97b6074721aeecf632dc753856
8 N9f61b655c712431f858a0cf734970403
9 Nc47cf00d10104474a743c30b86c973cf
10 Nc60ed99513fe43938ea425cf10d0f718
11 Ncb59a38122b84893bf519768aa8b4175
12 Ne2111c69f14c47f09d3f05b51c16ae08
13 Nfc50a7dac6a641eaab472e2e91753215
14 anzsrc-for:11
15 anzsrc-for:1115
16 schema:author N8207fb25a3f0435e86cdc6218d948bfe
17 schema:citation sg:pub.10.1007/978-3-0348-7775-6_1
18 sg:pub.10.1023/a:1011915402914
19 sg:pub.10.1038/35068566
20 https://app.dimensions.ai/details/publication/pub.1076341235
21 https://app.dimensions.ai/details/publication/pub.1078954397
22 https://app.dimensions.ai/details/publication/pub.1082404032
23 https://app.dimensions.ai/details/publication/pub.1082883026
24 https://app.dimensions.ai/details/publication/pub.1082959712
25 https://app.dimensions.ai/details/publication/pub.1083060294
26 https://app.dimensions.ai/details/publication/pub.1083060296
27 https://app.dimensions.ai/details/publication/pub.1083326786
28 https://app.dimensions.ai/details/publication/pub.1083364770
29 https://doi.org/10.1002/(sici)1096-9896(199703)181:3<257::aid-path756>3.0.co;2-u
30 https://doi.org/10.1002/1529-0131(200006)43:6<1266::aid-anr9>3.0.co;2-p
31 https://doi.org/10.1006/abbi.1996.0294
32 https://doi.org/10.1006/abbi.1996.9752
33 https://doi.org/10.1006/abbi.1999.1496
34 https://doi.org/10.1006/bbrc.2000.3219
35 https://doi.org/10.1016/0003-9861(87)90291-8
36 https://doi.org/10.1016/0167-4781(94)90074-4
37 https://doi.org/10.1016/j.bcp.2003.12.012
38 https://doi.org/10.1016/s0003-9861(02)00558-1
39 https://doi.org/10.1016/s0006-2952(02)01423-5
40 https://doi.org/10.1016/s0014-2999(03)01968-x
41 https://doi.org/10.1016/s0163-7258(01)00165-6
42 https://doi.org/10.1016/s0165-6147(99)01370-x
43 https://doi.org/10.1016/s0304-4165(02)00480-4
44 https://doi.org/10.1016/s0378-4274(97)00108-2
45 https://doi.org/10.1016/s0378-4347(01)00286-9
46 https://doi.org/10.1016/s1357-2725(97)00063-0
47 https://doi.org/10.1038/sj.bjp.0701148
48 https://doi.org/10.1038/sj.bjp.0703248
49 https://doi.org/10.1038/sj.bjp.0703486
50 https://doi.org/10.1053/jhep.2000.8532
51 https://doi.org/10.1096/fj.02-0195fje
52 https://doi.org/10.1124/jpet.102.041582
53 https://doi.org/10.1146/annurev.immunol.15.1.323
54 https://doi.org/10.1152/ajpregu.1994.267.6.r1431
55 https://doi.org/10.1152/ajpregu.1997.272.3.r862
56 https://doi.org/10.3109/00498259409038673
57 https://doi.org/10.3109/00498259409043263
58 https://doi.org/10.3109/03602539709002246
59 schema:datePublished 2005-01
60 schema:datePublishedReg 2005-01-01
61 schema:description PURPOSE: This study was designed to examine the effect of Freund's complete adjuvant (FCA)-induced inflammation on liver P450 expression and activities in the first 7 days that followed a single FCA injection in the rat hindpaw. METHODS: Rats were humanely sacrificed at regular time points, plasma and liver samples were collected, liver mRNA extracted, and liver microsomes prepared. RESULTS: FCA injection led to the development of an acute inflammatory response evidenced by paw edema and increased alpha-1-acid glycoprotein (AGP) and total-nitrite (NOx) plasma concentrations. Plasma IL-6 levels were significantly higher in FCA-treated rats than in controls at 8 h post-FCA. Within 24 h, these changes were accompanied by a rapid decrease in total P450 contents in FCA-treated rat liver and the selective downregulation of specific CYP isoforms, as illustrated by decreased mRNA levels (CYP2B, CYP2CI1, CYP3A1, and CYP2E1), protein contents (CYP2B, CYP2C11, and CYP2E1) or catalytic activities (CYP2C6, CYP2C11, and CYP2E1). CYP3A1 mRNA levels were severely decreased by FCA administration, whereas CYP3A2 mRNA and protein levels remained unchanged. CONCLUSIONS: These early biochemical and metabolic modifications may have pharmacokinetic and pharmacodynamic consequences when hepatically cleared drugs are administered to FCA-treated rats, especially within the first 24-72 h post-FCA.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N736538939de2425d8703ec25a5520b79
66 Nb60cfd53858b4539b9910844ab643211
67 sg:journal.1094644
68 schema:name Selective Downregulation of Hepatic Cytochrome P450 Expression and Activity in a Rat Model of Inflammatory Pain
69 schema:pagination 62-70
70 schema:productId N012b0f38c6aa44c7ae1663faea0a37a9
71 N3eefdb81dd18489d89b3eda50880ff0e
72 N5a05ee7b08f546e38575a1d67b9d1690
73 N5b6e62d5b4554f15b97dca2546060ccd
74 Ncd7e7bc2667d4ec798967213c6838cd9
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005154680
76 https://doi.org/10.1007/s11095-004-9010-6
77 schema:sdDatePublished 2019-04-10T14:11
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N9976649d10a144a39a94b450a7cd803d
80 schema:url http://link.springer.com/10.1007%2Fs11095-004-9010-6
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N012b0f38c6aa44c7ae1663faea0a37a9 schema:name doi
85 schema:value 10.1007/s11095-004-9010-6
86 rdf:type schema:PropertyValue
87 N07fa1cbf02c14bad8b35b900e2100b74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Inflammation
89 rdf:type schema:DefinedTerm
90 N0def1a53f49a495c88b97644a0135cf5 rdf:first Ndf67549709ff4112bdc41ae0b9753bdf
91 rdf:rest N10c3bbd3a14348e9b44e0d74e092a311
92 N10c3bbd3a14348e9b44e0d74e092a311 rdf:first sg:person.0755157500.46
93 rdf:rest Nc9c4bc33c03b4a49a67a21f8c2c57a01
94 N12012533c4604d7eb7ceb9e3d698ef03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Male
96 rdf:type schema:DefinedTerm
97 N2e454209f0eb4536aabae7b394a7ecad schema:name AstraZeneca R & D Montréal, Information not available, Ville St-Laurent, Québec, Canada
98 rdf:type schema:Organization
99 N36f62079351041bebe68abb8d5619f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Inflammation Mediators
101 rdf:type schema:DefinedTerm
102 N3eefdb81dd18489d89b3eda50880ff0e schema:name pubmed_id
103 schema:value 15771231
104 rdf:type schema:PropertyValue
105 N45f65e51773843d2bb972e988a5b1c95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N4d3e66e4af384e70acfdb26131c54dc8 schema:name AstraZeneca R & D Montréal, Information not available, Ville St-Laurent, Québec, Canada
109 rdf:type schema:Organization
110 N5a05ee7b08f546e38575a1d67b9d1690 schema:name nlm_unique_id
111 schema:value 8406521
112 rdf:type schema:PropertyValue
113 N5b6e62d5b4554f15b97dca2546060ccd schema:name readcube_id
114 schema:value 188f12aa7d74382529fea17200da35515da4337a9ba20c6324440c3a0d7122fc
115 rdf:type schema:PropertyValue
116 N736538939de2425d8703ec25a5520b79 schema:issueNumber 1
117 rdf:type schema:PublicationIssue
118 N77b2176508b9405aac2df068166817d3 rdf:first sg:person.01003273335.50
119 rdf:rest rdf:nil
120 N80e357f954d5484786597eb37e1aaf83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Down-Regulation
122 rdf:type schema:DefinedTerm
123 N8207fb25a3f0435e86cdc6218d948bfe rdf:first sg:person.0610325477.82
124 rdf:rest Nf52a751ed36a4f5991892b57ac498cc9
125 N9203f77b2a854622ac5ed83ef989747c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Rats
127 rdf:type schema:DefinedTerm
128 N95a36b97b6074721aeecf632dc753856 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Liver
130 rdf:type schema:DefinedTerm
131 N9976649d10a144a39a94b450a7cd803d schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N9f61b655c712431f858a0cf734970403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cytochrome P-450 Enzyme Inhibitors
135 rdf:type schema:DefinedTerm
136 Nb60cfd53858b4539b9910844ab643211 schema:volumeNumber 22
137 rdf:type schema:PublicationVolume
138 Nc47cf00d10104474a743c30b86c973cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Pain
140 rdf:type schema:DefinedTerm
141 Nc60ed99513fe43938ea425cf10d0f718 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Freund's Adjuvant
143 rdf:type schema:DefinedTerm
144 Nc9c4bc33c03b4a49a67a21f8c2c57a01 rdf:first sg:person.01203232621.90
145 rdf:rest N77b2176508b9405aac2df068166817d3
146 Ncb59a38122b84893bf519768aa8b4175 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Disease Models, Animal
148 rdf:type schema:DefinedTerm
149 Ncd7e7bc2667d4ec798967213c6838cd9 schema:name dimensions_id
150 schema:value pub.1005154680
151 rdf:type schema:PropertyValue
152 Ndf67549709ff4112bdc41ae0b9753bdf schema:affiliation N2e454209f0eb4536aabae7b394a7ecad
153 schema:familyName Vu
154 schema:givenName Huy Khan
155 rdf:type schema:Person
156 Ne2111c69f14c47f09d3f05b51c16ae08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cytochrome P-450 Enzyme System
158 rdf:type schema:DefinedTerm
159 Nebfbd680a4f945d9a27a77972fda27fe schema:name AstraZeneca R & D Montréal, Information not available, Ville St-Laurent, Québec, Canada
160 rdf:type schema:Organization
161 Nf52a751ed36a4f5991892b57ac498cc9 rdf:first sg:person.01220401352.45
162 rdf:rest N0def1a53f49a495c88b97644a0135cf5
163 Nfc50a7dac6a641eaab472e2e91753215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Rats, Sprague-Dawley
165 rdf:type schema:DefinedTerm
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
170 schema:name Pharmacology and Pharmaceutical Sciences
171 rdf:type schema:DefinedTerm
172 sg:journal.1094644 schema:issn 0724-8741
173 1573-904X
174 schema:name Pharmaceutical Research
175 rdf:type schema:Periodical
176 sg:person.01003273335.50 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
177 schema:familyName Ducharme
178 schema:givenName Julie
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003273335.50
180 rdf:type schema:Person
181 sg:person.01203232621.90 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
182 schema:familyName Brazier
183 schema:givenName Jean-Louis
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203232621.90
185 rdf:type schema:Person
186 sg:person.01220401352.45 schema:affiliation Nebfbd680a4f945d9a27a77972fda27fe
187 schema:familyName Dautrey
188 schema:givenName Sophie
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220401352.45
190 rdf:type schema:Person
191 sg:person.0610325477.82 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
192 schema:familyName Projean
193 schema:givenName Denis
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610325477.82
195 rdf:type schema:Person
196 sg:person.0755157500.46 schema:affiliation N4d3e66e4af384e70acfdb26131c54dc8
197 schema:familyName Groblewski
198 schema:givenName Thierry
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755157500.46
200 rdf:type schema:Person
201 sg:pub.10.1007/978-3-0348-7775-6_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030877609
202 https://doi.org/10.1007/978-3-0348-7775-6_1
203 rdf:type schema:CreativeWork
204 sg:pub.10.1023/a:1011915402914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007240519
205 https://doi.org/10.1023/a:1011915402914
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/35068566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040404719
208 https://doi.org/10.1038/35068566
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1076341235 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1078954397 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1082404032 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1082883026 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082959712 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083060294 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1083060296 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1083326786 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1083364770 schema:CreativeWork
219 https://doi.org/10.1002/(sici)1096-9896(199703)181:3<257::aid-path756>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1051119492
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/1529-0131(200006)43:6<1266::aid-anr9>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1044571324
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1006/abbi.1996.0294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047990788
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1006/abbi.1996.9752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006353765
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1006/abbi.1999.1496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050465932
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1006/bbrc.2000.3219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040799347
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/0003-9861(87)90291-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007746679
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0167-4781(94)90074-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000221238
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.bcp.2003.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004860096
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0003-9861(02)00558-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042927649
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0006-2952(02)01423-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030319295
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0014-2999(03)01968-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011483641
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0163-7258(01)00165-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023957035
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0165-6147(99)01370-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037440324
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0304-4165(02)00480-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015006562
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0378-4274(97)00108-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042988035
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0378-4347(01)00286-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009112751
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1357-2725(97)00063-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009697528
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1038/sj.bjp.0701148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045214705
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1038/sj.bjp.0703248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045071846
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1038/sj.bjp.0703486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039989275
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1053/jhep.2000.8532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013658506
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1096/fj.02-0195fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1027353228
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1124/jpet.102.041582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012942029
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1146/annurev.immunol.15.1.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033355295
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajpregu.1994.267.6.r1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082518365
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpregu.1997.272.3.r862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083066506
272 rdf:type schema:CreativeWork
273 https://doi.org/10.3109/00498259409038673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015582203
274 rdf:type schema:CreativeWork
275 https://doi.org/10.3109/00498259409043263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016927046
276 rdf:type schema:CreativeWork
277 https://doi.org/10.3109/03602539709002246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048605762
278 rdf:type schema:CreativeWork
279 https://www.grid.ac/institutes/grid.14848.31 schema:alternateName University of Montreal
280 schema:name AstraZeneca R & D Montréal, Information not available, Ville St-Laurent, Québec, Canada
281 Faculté de Pharmacie, Université de Montréal, Montréal, Québec, Canada
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...