Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-07

AUTHORS

E. V. Murzina, G. A. Sofronov, A. S. Simbirtsev, A. M. Ishchenko, T. O. Antipova, N. V. Aksenova, O. M. Veselova, V. V. Zatsepin

ABSTRACT

The radioprotective efficacy of recombinant flagellin (FL) and interleukin-1 beta (IL-1) administered in combinations for preventive or therapeutic purposes was studied in experiments on white mongrel mice. The drugs were administered i.p. at doses of 1 mg/kg (FL) and 50 μg/kg (IL-1β). Simultaneous administration of the drugs in the early stages before irradiation was shown to be most efficacious in terms of 30-day survival of mice exposed to x-rays at a dose of 7.5 Gy (100% survival of mice vs. 53% survival in the control group, p < 0.01). Sequential administration of FL before exposure and IL-1β after exposure increased survival of the mice by 40% (p < 0.05). The results indicated that combined use of biotechnological drugs for radioprotection was promising. More... »

PAGES

1-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-019-1910-1

DOI

http://dx.doi.org/10.1007/s11094-019-1910-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111253227


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146 S. M. Kirov Military Medical Academy, Ministry of Defense of the RF, 194044, St. Petersburg, Russia
147 rdf:type schema:Organization
 




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