Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-08

AUTHORS

R. E. Khoma, V. O. Gelmboldt, A. A. Énnan, T. L. Gridina, A. S. Fedchuk, V. P. Lozitsky, I. M. Rakipov, A. S. Vladyka

ABSTRACT

Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture. More... »

PAGES

436-439

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-019-02016-w

DOI

http://dx.doi.org/10.1007/s11094-019-02016-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120795375


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