Efficient Synthesis of 21-Acetoxypregna-1,4,9(11),16-Tetraene-3,20-Dione, a Key Intermediate in the Synthesis of Highly Active Fluorinated Corticosteroids from 9α-Hydroxyandrostenedione View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11-15

AUTHORS

V. A. Andryushina, T. S. Stytsenko, N. V. Karpova, V. V. Yaderets, V. V. Dzhavakhiya

ABSTRACT

An efficient synthesis of 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, a key intermediate in the synthesis of highly active fluorinated corticosteroids from phytosterols, was developed. The method consisted of an original sequence of chemical and microbiological reactions and could be used to synthesize betamethasone, sinaflan, triamcinolone, and other fluorinated corticoids.

PAGES

776-780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-018-1898-y

DOI

http://dx.doi.org/10.1007/s11094-018-1898-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109909328


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