Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation View Full Text


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Article Info

DATE

2018-06

AUTHORS

M. Azeem, Y. Saleem, Z. Hussain, S. Zahoor, M. M. Javed

ABSTRACT

The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28°C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus. More... »

PAGES

284-289

References to SciGraph publications

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  • 2007-01. Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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  • 2010-01. Biotechnological production and applications of statins in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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  • 1997-10. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process in BIOTECHNOLOGY LETTERS
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  • 2009. thai in DICTIONARY OF GEMS AND GEMOLOGY
  • 2000-12. Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases in ANTONIE VAN LEEUWENHOEK
  • 2010-09. Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2002-04. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1991-09. Mutants of a lovastatin-hyperproducingAspergillus terreus deficient in the production of sulochrin in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2005-03. Light effects on cell development and secondary metabolism in Monascus in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11094-018-1807-4

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    http://dx.doi.org/10.1007/s11094-018-1807-4

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