Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02-16

AUTHORS

S. M. Medvedeva, A. Yu. Potapov, I. V. Gribkova, E. V. Katkova, V. B. Sulimov, Kh. S. Shikhaliev

ABSTRACT

New factor-Xa inhibitors in a series of pyrrolo[3,2,1-ij]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and H-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 – 40 μM) were discovered.

PAGES

975-979

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4

DOI

http://dx.doi.org/10.1007/s11094-018-1726-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101080504


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia", 
          "id": "http://www.grid.ac/institutes/grid.20567.36", 
          "name": [
            "Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Medvedeva", 
        "givenName": "S. M.", 
        "id": "sg:person.015227332177.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015227332177.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia", 
          "id": "http://www.grid.ac/institutes/grid.20567.36", 
          "name": [
            "Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Potapov", 
        "givenName": "A. Yu.", 
        "id": "sg:person.014577270043.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014577270043.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.415738.c", 
          "name": [
            "Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gribkova", 
        "givenName": "I. V.", 
        "id": "sg:person.0656267132.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656267132.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.14476.30", 
          "name": [
            "Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katkova", 
        "givenName": "E. V.", 
        "id": "sg:person.0631274055.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631274055.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.415738.c", 
          "name": [
            "Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sulimov", 
        "givenName": "V. B.", 
        "id": "sg:person.0677407255.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677407255.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia", 
          "id": "http://www.grid.ac/institutes/grid.14476.30", 
          "name": [
            "Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shikhaliev", 
        "givenName": "Kh. S.", 
        "id": "sg:person.012501266731.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501266731.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/0003088-200948010-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046841512", 
          "https://doi.org/10.2165/0003088-200948010-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11172-014-0801-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040504892", 
          "https://doi.org/10.1007/s11172-014-0801-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-006-5579-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035428172", 
          "https://doi.org/10.1007/s11239-006-5579-4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02-16", 
    "datePublishedReg": "2018-02-16", 
    "description": "New factor-Xa inhibitors in a series of pyrrolo[3,2,1-ij]quinoline-1,2-diones substituted by condensation at the \u03b2-carbonyl with rhodanine, arylamines, and H-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 \u2013 40 \u03bcM) were discovered.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11094-018-1726-4", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1371981", 
        "issn": [
          "0091-150X", 
          "1573-9031"
        ], 
        "name": "Pharmaceutical Chemistry Journal", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "keywords": [
      "factor-Xa inhibitor", 
      "anticoagulant activity", 
      "inhibitory constants", 
      "inhibitors", 
      "micromolar concentration range", 
      "molecular docking", 
      "activity", 
      "series", 
      "tryptamine", 
      "concentration range", 
      "arylamines", 
      "docking", 
      "carbonyl", 
      "rhodanine", 
      "condensation", 
      "synthesis", 
      "constants", 
      "range", 
      "New factor-Xa inhibitors", 
      "Promising factor-Xa inhibitors"
    ], 
    "name": "Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones", 
    "pagination": "975-979", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101080504"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11094-018-1726-4"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11094-018-1726-4", 
      "https://app.dimensions.ai/details/publication/pub.1101080504"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_785.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11094-018-1726-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4'


 

This table displays all metadata directly associated to this object as RDF triples.

131 TRIPLES      22 PREDICATES      48 URIs      37 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11094-018-1726-4 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author Nadc5efa39ccb4ef7b87167fd2375f901
4 schema:citation sg:pub.10.1007/s11172-014-0801-6
5 sg:pub.10.1007/s11239-006-5579-4
6 sg:pub.10.2165/0003088-200948010-00001
7 schema:datePublished 2018-02-16
8 schema:datePublishedReg 2018-02-16
9 schema:description New factor-Xa inhibitors in a series of pyrrolo[3,2,1-ij]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and H-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 – 40 μM) were discovered.
10 schema:genre article
11 schema:inLanguage en
12 schema:isAccessibleForFree false
13 schema:isPartOf Nb1e8aeee76a44433ad94eb7a27f14bc6
14 Nd098ac48d4314127883adb7dbe56e63c
15 sg:journal.1371981
16 schema:keywords New factor-Xa inhibitors
17 Promising factor-Xa inhibitors
18 activity
19 anticoagulant activity
20 arylamines
21 carbonyl
22 concentration range
23 condensation
24 constants
25 docking
26 factor-Xa inhibitor
27 inhibitors
28 inhibitory constants
29 micromolar concentration range
30 molecular docking
31 range
32 rhodanine
33 series
34 synthesis
35 tryptamine
36 schema:name Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones
37 schema:pagination 975-979
38 schema:productId N0246491b7ca148e399f318fe6dd19e08
39 N8f9617c193c747d88c132dd0ffd780af
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101080504
41 https://doi.org/10.1007/s11094-018-1726-4
42 schema:sdDatePublished 2022-01-01T18:49
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher Nd57936f49eae40fb9cab0927777769e5
45 schema:url https://doi.org/10.1007/s11094-018-1726-4
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N0246491b7ca148e399f318fe6dd19e08 schema:name dimensions_id
50 schema:value pub.1101080504
51 rdf:type schema:PropertyValue
52 N0e8f62d7744940cfb8490c84c5ff9934 rdf:first sg:person.012501266731.37
53 rdf:rest rdf:nil
54 N3d8fc84e30124b45bab597c339eca67d rdf:first sg:person.0631274055.49
55 rdf:rest Nbbf2cd6e893c44c4ace25bb94bee34ad
56 N44f510f217d24a2da562035cefe60ff4 rdf:first sg:person.0656267132.91
57 rdf:rest N3d8fc84e30124b45bab597c339eca67d
58 N8f9617c193c747d88c132dd0ffd780af schema:name doi
59 schema:value 10.1007/s11094-018-1726-4
60 rdf:type schema:PropertyValue
61 N95ab57a2fc96491daa7e336cd533815f rdf:first sg:person.014577270043.19
62 rdf:rest N44f510f217d24a2da562035cefe60ff4
63 Nadc5efa39ccb4ef7b87167fd2375f901 rdf:first sg:person.015227332177.49
64 rdf:rest N95ab57a2fc96491daa7e336cd533815f
65 Nb1e8aeee76a44433ad94eb7a27f14bc6 schema:issueNumber 11
66 rdf:type schema:PublicationIssue
67 Nbbf2cd6e893c44c4ace25bb94bee34ad rdf:first sg:person.0677407255.41
68 rdf:rest N0e8f62d7744940cfb8490c84c5ff9934
69 Nd098ac48d4314127883adb7dbe56e63c schema:volumeNumber 51
70 rdf:type schema:PublicationVolume
71 Nd57936f49eae40fb9cab0927777769e5 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
74 schema:name Medical and Health Sciences
75 rdf:type schema:DefinedTerm
76 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
77 schema:name Pharmacology and Pharmaceutical Sciences
78 rdf:type schema:DefinedTerm
79 sg:journal.1371981 schema:issn 0091-150X
80 1573-9031
81 schema:name Pharmaceutical Chemistry Journal
82 schema:publisher Springer Nature
83 rdf:type schema:Periodical
84 sg:person.012501266731.37 schema:affiliation grid-institutes:grid.14476.30
85 schema:familyName Shikhaliev
86 schema:givenName Kh. S.
87 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012501266731.37
88 rdf:type schema:Person
89 sg:person.014577270043.19 schema:affiliation grid-institutes:grid.20567.36
90 schema:familyName Potapov
91 schema:givenName A. Yu.
92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014577270043.19
93 rdf:type schema:Person
94 sg:person.015227332177.49 schema:affiliation grid-institutes:grid.20567.36
95 schema:familyName Medvedeva
96 schema:givenName S. M.
97 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015227332177.49
98 rdf:type schema:Person
99 sg:person.0631274055.49 schema:affiliation grid-institutes:grid.14476.30
100 schema:familyName Katkova
101 schema:givenName E. V.
102 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631274055.49
103 rdf:type schema:Person
104 sg:person.0656267132.91 schema:affiliation grid-institutes:grid.415738.c
105 schema:familyName Gribkova
106 schema:givenName I. V.
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656267132.91
108 rdf:type schema:Person
109 sg:person.0677407255.41 schema:affiliation grid-institutes:grid.415738.c
110 schema:familyName Sulimov
111 schema:givenName V. B.
112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677407255.41
113 rdf:type schema:Person
114 sg:pub.10.1007/s11172-014-0801-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040504892
115 https://doi.org/10.1007/s11172-014-0801-6
116 rdf:type schema:CreativeWork
117 sg:pub.10.1007/s11239-006-5579-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035428172
118 https://doi.org/10.1007/s11239-006-5579-4
119 rdf:type schema:CreativeWork
120 sg:pub.10.2165/0003088-200948010-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046841512
121 https://doi.org/10.2165/0003088-200948010-00001
122 rdf:type schema:CreativeWork
123 grid-institutes:grid.14476.30 schema:alternateName Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia
124 schema:name Research Computing Centre, M. V. Lomonosov Moscow State University, 1/4 Leninskie Gory, 119991, Moscow, Russia
125 rdf:type schema:Organization
126 grid-institutes:grid.20567.36 schema:alternateName Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia
127 schema:name Voronezh State University, 1 Universitetskaya Sq, 394006, Voronezh, Russia
128 rdf:type schema:Organization
129 grid-institutes:grid.415738.c schema:alternateName Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia
130 schema:name Federal Hematological Research Center, Ministry of Health of the Russian Federation, 4 Novyi Zykovskii Proezd, 125167, Moscow, Russia
131 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...