Synthesis, Docking, and Anticoagulant Activity of New Factor-Xa Inhibitors in a Series of Pyrrolo[3,2,1-ij]Quinoline-1,2-Diones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02-16

AUTHORS

S. M. Medvedeva, A. Yu. Potapov, I. V. Gribkova, E. V. Katkova, V. B. Sulimov, Kh. S. Shikhaliev

ABSTRACT

New factor-Xa inhibitors in a series of pyrrolo[3,2,1-ij]quinoline-1,2-diones substituted by condensation at the β-carbonyl with rhodanine, arylamines, and H-tryptamines were synthesized, characterized, and studied by molecular docking. Promising factor-Xa inhibitors with inhibitory constants in the micromolar concentration range (IC50 = 0.7 – 40 μM) were discovered.

PAGES

975-979

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-018-1726-4

DOI

http://dx.doi.org/10.1007/s11094-018-1726-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101080504


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