Synthesis and Antimicrobial Activity of Tricyclic Quinazolinethiones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

A. O. Nasrullaev, Zh. I. Islamova, B. Zh. Élmuradov, A. M. Bektemirov, S. O. Osipova, Z. A. Khushbaktova, V. N. Syrov, Kh. M. Shakhidoyatov

ABSTRACT

Deoxyvasicine thione (III) and mackinazoline thione (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-thione, IV) were synthesized and condensed with aromatic and heterocyclic aldehydes at the α-methylene [CH2-3 (III) or CH2-6 (IV)]. Either 3- and 6-arylidene derivatives (V – XIII) or 6-hydroxymethylaryl derivatives (XIV) were formed depending on the reaction conditions. Formylation of IV synthesized the 6-hydroxymethylidene derivative (XV). 6-Chloro-, -hydroseleno-, and -anilinomethylidenemackinazoline thiones (XVI – XIX) were also synthesized. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied. More... »

PAGES

355-360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-017-1614-3

DOI

http://dx.doi.org/10.1007/s11094-017-1614-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091587212


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