N-Phenylacetylglycyl-L-Proline Ethyl Ester Converts into Cyclo-L-Prolylglycine Showing a Similar Spectrum of Neuropsychotropic Activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-17

AUTHORS

T. A. Gudasheva, K. N. Kolyasnikova, E. A. Kuznetsova, S. A. Litvinova, N. N. Zolotov, T. A. Voronina, R. U. Ostrovskaya, S. B. Seredenin

ABSTRACT

Previously designed cyclo-L-prolylglycine (CPG), a peptide prototype of piracetam, was discovered as an endogenous compound in rat brain and exhibited nootropic and anxiolytic properties. N-Phenylacetylglycyl-L-proline ethyl ester (GZK-111) was synthesized in the present work. It was established that GZK-111 converted to CPG and possessed nootropic, anxiolytic, and antihypoxic activities typical of CPG at doses of 0.1 – 1.5 mg/kg (i.p.). The effects of both GZK-111 and CPG were stereoselective with only the L-enantiomers being active. GZK-111 could be considered as a prodrug that enhanced cognitive functioning with an anxiolytic component. More... »

PAGES

705-710

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-017-1516-4

DOI

http://dx.doi.org/10.1007/s11094-017-1516-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083873319


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