14α-Hydroxylation of steroids by mycelium of the mold fungus Curvularia lunata (VKPM F-981) to produce precursors for synthesizing new steroidal ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

V. A. Andryushina, N. E. Voishvillo, A. V. Druzhinina, T. S. Stytsenko, V. V. Yaderets, M. A. Petrosyan, O. A. Zeinalov

ABSTRACT

Five 14α-hydroxylated derivatives of androstane and pregnane steroids were obtained using mycelium of the mold fungus Curvularia lunata (VKPM F-981). The conditions for microbiological transformation of androst-4-en-3,17-dione that enabled its 14α-hydroxy analog to be obtained in yields up to 60% with substrate loading 6 g/L were determined. The 21-acetoxy analog of proligestone was synthesized from 14α-hydroxycortexolone that was formed simultaneously with hydrocortisone during hydroxylation of cortexolone by C. lunata. The resulting 14α- and 14α,21-hydroxysteroids could be used as precursors for the synthesis of new drugs. More... »

PAGES

103-108

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-013-0905-6

DOI

http://dx.doi.org/10.1007/s11094-013-0905-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001412183


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