Synthesis and biological activity of synthetic 17α-hydroxyprogesterone derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07

AUTHORS

O. A. Zeinalov, V. V. Yaderets, T. S. Stytsenko, M. A. Petrosyan, V. A. Andryushina

ABSTRACT

Gestagenic and contraceptive (in combination with estrogen) activities of megestrol acetate, proligestone, and two esters of mepregenol acetate (butyrate and hemisuccinate) were studied. The absence of a correlation between the gestagenic and contraceptive activity (CA) of the synthetic derivatives of 17α-hydroxyprogesterone was established. Of two compounds (proligestone and megestrol acetate) showing the maximum (100%) CA (in combination with ethynylestradiol), proligestone was practically devoid of gestagenic activity while megestrol acetate was a highly active gestagen. It was confirmed that the gestagenic activities of injected megestrol acetate and mepregenol acetate tended to exceed their peroral activities. Pure estrogen was found to contribute to the CA of the mepregenol esters. More... »

PAGES

203-206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11094-012-0761-9

DOI

http://dx.doi.org/10.1007/s11094-012-0761-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045206933


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