The Effect of Cotinine on Nicotine- and Cocaine-Induced Dopamine Release in the Nucleus Accumbens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

I. Sziráki, H. Sershen, M. Benuck, M. Lipovac, A. Hashim, T. B. Cooper, D. Allen, A. Lajtha

ABSTRACT

Cotinine is the major metabolite of nicotine. Nicotine is rapidly metabolized and has a short half-life, but cotinine is metabolized and eliminated at a much lower rate. Because of the resulting increase with time in the cotinine to nicotine ratio in the body, including in the brain, it is of interest to examine the effect of cotinine on nicotine-induced changes. In studies on conscious, freely-moving rats, intravenous administration of either nicotine or cocaine induced the release of dopamine in the nucleus accumbens, as assayed by microdialysis. Prior intravenous administration of a high dose of cotinine (500 microg/kg) inhibited this nicotine- or cocaine-induced dopamine release. The action of cotinine does not seem to occur through its effect on the metabolism of nicotine or on its binding at the receptor site, because cotinine, unlike nicotine, does not affect the binding of the nicotinic ligand cytisine. The findings suggest that cotinine affects a putative component of the reward mechanism, and as such could have therapeutic value. More... »

PAGES

1471

References to SciGraph publications

  • 1985-05. Steady-state concentration of cotinine as a measure of nicotine-intake by smokers in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1997-06. Cotinine effects on nicotine metabolism in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1997-12. Metabolism of (−)-(S)-nicotine by guinea pig and rat brain: identification of cotinine in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • 1996-07. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs in NATURE
  • 1994-11. Metabolism of nicotine to cotinine studied by a dual stable isotope method in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11064-999-0001-1

    DOI

    http://dx.doi.org/10.1007/s11064-999-0001-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041628562

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10555788


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