Effects of α-Synuclein Monomers Administration in the Gigantocellular Reticular Nucleus on Neurotransmission in Mouse Model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Ilona Joniec-Maciejak, Agnieszka Ciesielska, Łukasz A. Poniatowski, Adriana Wawer, Anna Sznejder-Pachołek, Ewa Wojnar, Piotr Maciejak, Dagmara Mirowska-Guzel

ABSTRACT

The aim of the study was to examine the Braak's hypothesis to explain the spreading and distribution of the neuropathological changes observed in the course of Parkinson's disease among ascending neuroanatomical regions. We investigated the neurotransmitter levels (monoamines and amino acid concentration) as well as tyrosine hydroxylase (TH) and transglutaminase-2 (TG2) mRNA expression in the mouse striata (ST) after intracerebral α-synuclein (ASN) administration into gigantocellular reticular nucleus (Gi). Male C57BL/10 Tar mice were used in this study. ASN was administrated by stereotactic injection into Gi area (4 μl; 1 μg/μl) and mice were decapitated after 1, 4 or 12 weeks post injection. The neurotransmitters concentration in ST were evaluated using HPLC detection. TH and TG2 mRNA expression were examined by Real-Time PCR method. At 4 and 12 weeks after ASN administration we observed decrease of DA concentration in ST relative to control groups and we found a significantly higher concentration one of the DA metabolites-DOPAC. At these time points, we also noticed the increase in DA turnover determined as DOPAC/DA ratio. Additionally, at 4 and 12 weeks after ASN injection we noted decreasing of TH mRNA expression. Our findings corresponds with the Braak's theory about the presence of the first neuropathological changes within brainstem and then with time affecting higher neuroanatomical regions. These results obtained after administration of ASN monomers to the Gi area may be useful to explain the pathogenesis of Parkinson's disease. More... »

PAGES

968-977

References to SciGraph publications

  • 2009-02. Olfactory bulb α-synucleinopathy has high specificity and sensitivity for Lewy body disorders in ACTA NEUROPATHOLOGICA
  • 2004-10. Lewy body-related α-synucleinopathy in the aged human brain in JOURNAL OF NEURAL TRANSMISSION
  • 2015-03. Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson’s disease in JOURNAL OF NEURAL TRANSMISSION
  • 2013-04. The Central Theme of Parkinson’s Disease: α-Synuclein in MOLECULAR NEUROBIOLOGY
  • 2017-03-23. Parkinson disease in NATURE REVIEWS DISEASE PRIMERS
  • 2001-03. α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei in ACTA NEUROPATHOLOGICA
  • 1996-02. Changes of unmyelinated nerve fibers in sural nerve in amyotrophic lateral sclerosis, Parkinson’s disease and multiple system atrophy in ACTA NEUROPATHOLOGICA
  • 2010-01. Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-κB activity in hypoxic tumor cells in ONCOGENE
  • 2017-06-08. Non-motor features of Parkinson disease in NATURE REVIEWS NEUROSCIENCE
  • 2000-03. Parkinson’s disease: affection of brain stem nuclei controlling premotor and motor neurons of the somatomotor system in ACTA NEUROPATHOLOGICA
  • 2013-01. The many faces of α-synuclein: from structure and toxicity to therapeutic target in NATURE REVIEWS NEUROSCIENCE
  • 2011-09. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation in NATURE
  • 2012-11. Spinal cord lesions in sporadic Parkinson’s disease in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11064-019-02732-5

    DOI

    http://dx.doi.org/10.1007/s11064-019-02732-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112096492

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30758814


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