Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Jun Zhang, Yunxia Wang, Xin Qi

ABSTRACT

Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Repeatedly intraperitoneal injection of morphine led to morphine analgesic tolerance on day 5 post-injection evidenced by a marked decrease in morphine's maximal possible analgesic effect and hyperalgesia on day 6 post-injection demonstrated by significant increases in paw withdrawal frequency in response to mechanical stimulation and decreases in paw withdrawal latency in response to cold stimulation on bilateral sides. Co-intraperitoneal injection with rapamycin prevented the development of morphine analgesic tolerance and hyperalgesia. Moreover, on day 6 after morphine injection, co-intraperitoneal injection with rapamycin reduced the established morphine tolerance and hyperalgesia. Co-intraperitoneal injection of rapamycin also attenuated the morphine-induced increases in the levels of phosphorylated mTOR and its downstream target phosphorylated 4E-BP1 in the spinal cord dorsal horn. Our findings indicate that, like intrathecal injection, systemic administration of rapamycin has significant effects on both induction and maintenance of morphine tolerance and hyperalgesia. Systemic mTOR inhibitors could serve as promising medications for use as adjuvants with opioids in clinical chronic pain management. More... »

PAGES

465-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11064-018-2699-0

DOI

http://dx.doi.org/10.1007/s11064-018-2699-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110580363

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30547365


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China", 
            "Department of Anesthesiology, Tianjin Union Medical Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Anesthesiology, Tianjin Union Medical Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yunxia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, 300121, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Xin", 
        "id": "sg:person.01263642763.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263642763.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181ed83a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001060108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181ed83a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001060108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mjt.0b013e3181ed83a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001060108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004966437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2010.08.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006857352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2014.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017565488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2010.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018959580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.14.7731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026111701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2013.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028959896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci70236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029708062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.102327699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030525097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2012.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038090359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.887201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043327770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1744806916682242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045846520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1744806916682242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045846520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbapap.2007.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046971738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12990-015-0030-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047729232", 
          "https://doi.org/10.1186/s12990-015-0030-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.10.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050944402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bip.20254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052837084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.31480/2330-4871/027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079144818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms14712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084128936", 
          "https://doi.org/10.1038/ncomms14712"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Repeatedly intraperitoneal injection of morphine led to morphine analgesic tolerance on day 5 post-injection evidenced by a marked decrease in morphine's maximal possible analgesic effect and hyperalgesia on day 6 post-injection demonstrated by significant increases in paw withdrawal frequency in response to mechanical stimulation and decreases in paw withdrawal latency in response to cold stimulation on bilateral sides. Co-intraperitoneal injection with rapamycin prevented the development of morphine analgesic tolerance and hyperalgesia. Moreover, on day 6 after morphine injection, co-intraperitoneal injection with rapamycin reduced the established morphine tolerance and hyperalgesia. Co-intraperitoneal injection of rapamycin also attenuated the morphine-induced increases in the levels of phosphorylated mTOR and its downstream target phosphorylated 4E-BP1 in the spinal cord dorsal horn. Our findings indicate that, like intrathecal injection, systemic administration of rapamycin has significant effects on both induction and maintenance of morphine tolerance and hyperalgesia. Systemic mTOR inhibitors could serve as promising medications for use as adjuvants with opioids in clinical chronic pain management.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11064-018-2699-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085962", 
        "issn": [
          "0364-3190", 
          "1573-6903"
        ], 
        "name": "Neurochemical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice", 
    "pagination": "465-471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8a73e30b5234adf05b0b4abaa1a2f460e6dc5411e7f345d1104be956a7f6d368"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30547365"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7613461"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11064-018-2699-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110580363"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11064-018-2699-0", 
      "https://app.dimensions.ai/details/publication/pub.1110580363"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99806_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11064-018-2699-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-2699-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-2699-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-2699-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-2699-0'


 

This table displays all metadata directly associated to this object as RDF triples.

142 TRIPLES      21 PREDICATES      48 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11064-018-2699-0 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author N58854567bbe24167a8c9b119ce09c0a3
4 schema:citation sg:pub.10.1038/ncomms14712
5 sg:pub.10.1186/s12990-015-0030-5
6 https://doi.org/10.1002/bip.20254
7 https://doi.org/10.1016/j.bbapap.2007.08.015
8 https://doi.org/10.1016/j.brainres.2010.04.010
9 https://doi.org/10.1016/j.brainres.2013.04.003
10 https://doi.org/10.1016/j.ctrv.2012.12.012
11 https://doi.org/10.1016/j.jpsychires.2014.08.009
12 https://doi.org/10.1016/j.neuron.2008.10.055
13 https://doi.org/10.1016/j.neuron.2011.10.012
14 https://doi.org/10.1016/j.neuroscience.2010.08.064
15 https://doi.org/10.1073/pnas.102327699
16 https://doi.org/10.1073/pnas.96.14.7731
17 https://doi.org/10.1097/mjt.0b013e3181ed83a0
18 https://doi.org/10.1101/gad.887201
19 https://doi.org/10.1172/jci70236
20 https://doi.org/10.1177/1744806916682242
21 https://doi.org/10.2741/3596
22 https://doi.org/10.31480/2330-4871/027
23 schema:datePublished 2019-02
24 schema:datePublishedReg 2019-02-01
25 schema:description Previous studies showed that repeated intrathecal morphine injection activated the mammalian target of rapamycin complex 1 (mTORC1) in spinal dorsal horn neurons and that blocking this activation by intrathecal infusion of rapamycin, a specific mTORC1 inhibitor, prevented the initiation of morphine-induced tolerance and hyperalgesia. However, in clinic, rapamycin is usually administrated orally. In this study, we examined whether systemic administration of rapamycin had the effect on morphine-induced tolerance and hyperalgesia in mice. Repeatedly intraperitoneal injection of morphine led to morphine analgesic tolerance on day 5 post-injection evidenced by a marked decrease in morphine's maximal possible analgesic effect and hyperalgesia on day 6 post-injection demonstrated by significant increases in paw withdrawal frequency in response to mechanical stimulation and decreases in paw withdrawal latency in response to cold stimulation on bilateral sides. Co-intraperitoneal injection with rapamycin prevented the development of morphine analgesic tolerance and hyperalgesia. Moreover, on day 6 after morphine injection, co-intraperitoneal injection with rapamycin reduced the established morphine tolerance and hyperalgesia. Co-intraperitoneal injection of rapamycin also attenuated the morphine-induced increases in the levels of phosphorylated mTOR and its downstream target phosphorylated 4E-BP1 in the spinal cord dorsal horn. Our findings indicate that, like intrathecal injection, systemic administration of rapamycin has significant effects on both induction and maintenance of morphine tolerance and hyperalgesia. Systemic mTOR inhibitors could serve as promising medications for use as adjuvants with opioids in clinical chronic pain management.
26 schema:genre research_article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N08cb6f94251f4e869b236db9b4160a91
30 Ne5ebbc6e6f2647fb9af090b2ea9da1fa
31 sg:journal.1085962
32 schema:name Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice
33 schema:pagination 465-471
34 schema:productId N13cabfb256014c928f6445e4e777680a
35 N2c320aba596f4b77bbb43800df760742
36 N4ca707191cae4f2ca18c5677a7e93441
37 Nc683aaf0979a42689199a780f08a8066
38 Nf753d7d23d964a7c82244b7663d1ccb8
39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110580363
40 https://doi.org/10.1007/s11064-018-2699-0
41 schema:sdDatePublished 2019-04-11T09:32
42 schema:sdLicense https://scigraph.springernature.com/explorer/license/
43 schema:sdPublisher N99d0e4dfd954438abb384ae02b38a43e
44 schema:url https://link.springer.com/10.1007%2Fs11064-018-2699-0
45 sgo:license sg:explorer/license/
46 sgo:sdDataset articles
47 rdf:type schema:ScholarlyArticle
48 N08cb6f94251f4e869b236db9b4160a91 schema:volumeNumber 44
49 rdf:type schema:PublicationVolume
50 N13cabfb256014c928f6445e4e777680a schema:name readcube_id
51 schema:value 8a73e30b5234adf05b0b4abaa1a2f460e6dc5411e7f345d1104be956a7f6d368
52 rdf:type schema:PropertyValue
53 N1d2c2d310a274fd8b52d1df5e69c7b7b rdf:first sg:person.01263642763.85
54 rdf:rest rdf:nil
55 N2c320aba596f4b77bbb43800df760742 schema:name dimensions_id
56 schema:value pub.1110580363
57 rdf:type schema:PropertyValue
58 N4ca707191cae4f2ca18c5677a7e93441 schema:name nlm_unique_id
59 schema:value 7613461
60 rdf:type schema:PropertyValue
61 N58854567bbe24167a8c9b119ce09c0a3 rdf:first Nc26366831cad48ce867ced731c76664c
62 rdf:rest Na655cd2e482745c1a3de33a6ba12f93f
63 N99d0e4dfd954438abb384ae02b38a43e schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 Na655cd2e482745c1a3de33a6ba12f93f rdf:first Nf7de20688302496588a4a6084292fee4
66 rdf:rest N1d2c2d310a274fd8b52d1df5e69c7b7b
67 Nc26366831cad48ce867ced731c76664c schema:affiliation https://www.grid.ac/institutes/grid.417031.0
68 schema:familyName Zhang
69 schema:givenName Jun
70 rdf:type schema:Person
71 Nc683aaf0979a42689199a780f08a8066 schema:name doi
72 schema:value 10.1007/s11064-018-2699-0
73 rdf:type schema:PropertyValue
74 Ne5ebbc6e6f2647fb9af090b2ea9da1fa schema:issueNumber 2
75 rdf:type schema:PublicationIssue
76 Nf753d7d23d964a7c82244b7663d1ccb8 schema:name pubmed_id
77 schema:value 30547365
78 rdf:type schema:PropertyValue
79 Nf7de20688302496588a4a6084292fee4 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
80 schema:familyName Wang
81 schema:givenName Yunxia
82 rdf:type schema:Person
83 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
84 schema:name Medical and Health Sciences
85 rdf:type schema:DefinedTerm
86 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
87 schema:name Pharmacology and Pharmaceutical Sciences
88 rdf:type schema:DefinedTerm
89 sg:journal.1085962 schema:issn 0364-3190
90 1573-6903
91 schema:name Neurochemical Research
92 rdf:type schema:Periodical
93 sg:person.01263642763.85 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
94 schema:familyName Qi
95 schema:givenName Xin
96 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263642763.85
97 rdf:type schema:Person
98 sg:pub.10.1038/ncomms14712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128936
99 https://doi.org/10.1038/ncomms14712
100 rdf:type schema:CreativeWork
101 sg:pub.10.1186/s12990-015-0030-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047729232
102 https://doi.org/10.1186/s12990-015-0030-5
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1002/bip.20254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052837084
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1016/j.bbapap.2007.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046971738
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1016/j.brainres.2010.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018959580
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/j.brainres.2013.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028959896
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/j.ctrv.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038090359
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/j.jpsychires.2014.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017565488
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/j.neuron.2008.10.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050944402
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/j.neuron.2011.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004966437
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/j.neuroscience.2010.08.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006857352
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1073/pnas.102327699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030525097
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1073/pnas.96.14.7731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026111701
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1097/mjt.0b013e3181ed83a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001060108
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1101/gad.887201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043327770
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1172/jci70236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029708062
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1177/1744806916682242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045846520
133 rdf:type schema:CreativeWork
134 https://doi.org/10.2741/3596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915798
135 rdf:type schema:CreativeWork
136 https://doi.org/10.31480/2330-4871/027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079144818
137 rdf:type schema:CreativeWork
138 https://www.grid.ac/institutes/grid.417031.0 schema:alternateName Tianjin People's Hospital
139 schema:name Department of Anesthesiology, Tianjin Union Medical Center, Tianjin, China
140 Department of Cardiovasology, Tianjin Union Medical Center, 190 Jieyuan St., Hongqiao District, 300121, Tianjin, China
141 School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
142 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...