Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice View Full Text


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Article Info

DATE

2019-04

AUTHORS

Michelle Lima Garcez, Adriani Paganini Damiani, Robson Pacheco, Lucas Rodrigues, Larissa Letieli de Abreu, Márcio Correa Alves, Vanessa Moraes de Andrade, Carina Rodrigues Boeck

ABSTRACT

Caffeine is a bioactive compound worldwide consumed with effect into the brain. Part of its action in reducing incidence or delaying Alzheimer's and Parkinson's diseases symptoms in human is credited to the adenosine receptors properties. However, the impact of caffeine consumption during aging on survival of brain cells remains debatable. This work, we investigated the effect of low-dose of caffeine on the ectonucleotidase activities, adenosine receptors content, and paying particular attention to its pro-survival effect during aging. Male young adult and aged Swiss mice drank water or caffeine (0.3 g/L) ad libitum for 4 weeks. The results showed that long-term caffeine treatment did not unchanged ATP, ADP or AMP hydrolysis in hippocampus when compared to the mice drank water. Nevertheless, the ATP/ADP hydrolysis ratio was higher in young adult (3:1) compared to the aged (1:1) animals regardless of treatment. The content of A1 receptors did not change in any groups of mice, but the content of A2A receptors was reduced in hippocampus of mice that consumed caffeine. Moreover, the cell viability results indicated that aged mice not only had increased pyknotic neurons in the hippocampus but also had reduced damage after caffeine treatment. Overall, these findings indicate a potential neuroprotective effect of caffeine during aging through the adenosinergic system. More... »

PAGES

787-795

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11064-018-02710-3

DOI

http://dx.doi.org/10.1007/s11064-018-02710-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111099951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30610653


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-02710-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-02710-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-02710-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11064-018-02710-3'


 

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273 schema:name Laboratório de Biologia Celular e Molecular, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense – UNESC, Criciúma, SC, Brazil
274 rdf:type schema:Organization
 




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