Juvenile Rats Show Altered Gut Microbiota After Exposure to Isoflurane as Neonates View Full Text


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Article Info

DATE

2019-04

AUTHORS

Likuan Wang, Xudong Yang, Haiyin Wu

ABSTRACT

Inhaled anesthetic agents may be neurotoxic to the developing brain of a neonatal rodent. Isoflurane is a commonly used volatile anesthetic agent for maintenance of general anesthesia in various types of surgery. Neonatal exposure to isoflurane has been implicated in long-term neurocognitive dysfunction in children. The mechanisms of isoflurane-induced neurotoxicity have not been fully elucidated. Disruption of gut microbiota is currently attracting considerable interest as a vital pathogeny of some neurologic disorders. In the rat model, it is unknown whether neonatal exposure to isoflurane impacts the gut microbiota composition of juvenile animals. In the present study, postnatal 7-day-old male rats were exposed to 1 minimum alveolar concentration isoflurane for 4 h. Non-anesthetized rats served as controls. The fecal microbiomes of rats were observed using 16S RNA sequencing technique on postnatal day 42. Results indicated that composition of gut microbiota of isoflurane-exposed rats was different from controls. Several bacteria taxa in isoflurane-exposed rats were different from those of controls at various taxonomic levels. In particular, the abundance of Firmicutes, Proteobacteria, Clostridia, Clostridiales, and Lachnospiraceae were significantly increased in exposed rats and the abundance of Bacteroidetes, Actinobacteria, Bacteroidia and Bacteroidaceae were significantly decreased compared to controls. These results may offer new insights into the pathogenesis of isoflurane-induced neurotoxicity. More... »

PAGES

776-786

References to SciGraph publications

  • 2018-12. Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats in JOURNAL OF NEUROINFLAMMATION
  • 2012-12. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice in JOURNAL OF NEUROINFLAMMATION
  • 2017-02. Neonatal Repeated Exposure to Isoflurane not Sevoflurane in Mice Reversibly Impaired Spatial Cognition at Juvenile-Age in NEUROCHEMICAL RESEARCH
  • 2013-08. Richness of human gut microbiome correlates with metabolic markers in NATURE
  • 2016-09. Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease in SCIENTIFIC REPORTS
  • 2013-05. Role of the gut microbiota in immunity and inflammatory disease in NATURE REVIEWS IMMUNOLOGY
  • 2017-04. Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination in JOURNAL OF ANESTHESIA
  • 2011-06. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2014-09. Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats in NEUROPSYCHOPHARMACOLOGY
  • 2015-07. Host microbiota constantly control maturation and function of microglia in the CNS in NATURE NEUROSCIENCE
  • 2018-05. Richness and ecosystem development across faecal snapshots of the gut microbiota in NATURE MICROBIOLOGY
  • 2015-10-14. The tantalizing links between gut microbes and the brain in NATURE
  • Journal

    TITLE

    Neurochemical Research

    ISSUE

    4

    VOLUME

    44

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11064-018-02707-y

    DOI

    http://dx.doi.org/10.1007/s11064-018-02707-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111058173

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30603984


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