Expression of Nucleoside Transporter in Freshly Isolated Neurons and Astrocytes from Mouse Brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

B. Li, L. Gu, L. Hertz, L. Peng

ABSTRACT

Nucleoside transporters comprise equilibrative ENT1-4 and concentrative CNT1-3. CNTs transport against an intracellular/extracellular gradient and are essential for transmitter removal, independently of metabolic need. ENT1-4 mediate transport until intracellular/extracellular equilibrium of the transported compound, but are very efficient, when the accumulated nucleoside or nucleobase is rapidly eliminated by metabolism. Most nucleoside transporters are membrane-bound, but ENT3 is mainly intracellular. This study uses freshly isolated neurons and astrocytes from two adult mouse strains. In one transgenic strain the neuronal marker Thy1 was associated with a compound fluorescing at one wavelength, and in the other the astrocytic marker GFAP was associated with a compound fluorescent at a different wavelength. Highly purified astrocytic and neuronal populations (as determined by presence/absence of cell-specific genes) were obtained from these mice by fluorescence-activated cell sorting. In each population mRNA analysis was performed by reverse-transcription polymerase chain reaction. CNT1 was absent in both cell types; all other nucleoside transporters were expressed to at least a similar degree (in relation to applied amount of RNA and to a house-keeping gene) in astrocytes as in neurons. Astrocytic ENT3 enrichment was dramatic, but it was not up-regulated after fluoxetine-mediated increase in DNA synthesis. A comparison with results obtained in cultured astrocytes shows that the latter are generally compatible with the present findings and suggests that many observations obtained in intact tissue, mainly by in situ hybridization (which also determines mRNA expression) may underestimate astrocytic nucleoside transporter expression. More... »

PAGES

2351-2358

References to SciGraph publications

  • 2007-08. Neurogenesis and depression: what animal models tell us about the link in EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
  • 2000-12. Modifications in phospholipase D activity and isoform expression occur upon maturation and differentiation in vivo and in vitro in human myeloid cells in LEUKEMIA
  • 2012. Isotope-Based Quantitation of Uptake, Release, and Metabolism of Glutamate and Glucose in Cultured Astrocytes in ASTROCYTES
  • 2010-09. Effects of Hypoxia, Glucose Deprivation and Recovery on the Expression of Nucleoside Transporters and Adenosine Uptake in Primary Culture of Rat Cortical Astrocytes in NEUROCHEMICAL RESEARCH
  • 2009-11. Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation in PSYCHOPHARMACOLOGY
  • 2012-11. Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia in NEUROCHEMICAL RESEARCH
  • 2007-08. Regulated ATP release from astrocytes through lysosome exocytosis in NATURE CELL BIOLOGY
  • 2012-11. Exocytosis in Astrocytes: Transmitter Release and Membrane Signal Regulation in NEUROCHEMICAL RESEARCH
  • 2002-02. Up-Regulation of 5-HT2B Receptor Density and Receptor-Mediated Glycogenolysis in Mouse Astrocytes by Long-Term Fluoxetine Administration in NEUROCHEMICAL RESEARCH
  • 2008-12. Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation in PSYCHOPHARMACOLOGY
  • 2012-11. Primary Cultures of Astrocytes: Their Value in Understanding Astrocytes in Health and Disease in NEUROCHEMICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11064-013-1146-5

    DOI

    http://dx.doi.org/10.1007/s11064-013-1146-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045311247

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24026568


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