Upregulation of Metallothioneins After Exposure of Cultured Primary Astrocytes to Silver Nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04-05

AUTHORS

Eva M. Luther, Maike M. Schmidt, Joerg Diendorf, Matthias Epple, Ralf Dringen

ABSTRACT

To test for the prolonged consequences of a short transient exposure of astrocytes to silver nanoparticles (AgNP), cultured primary astrocytes were incubated for 4 h in the presence of AgNP and the cell viability as well as various metabolic parameters were investigated during a subsequent incubation in AgNP-free medium. Acute exposure of astrocytes to AgNP led to a concentration-dependent increase in the specific cellular silver content to up to 46 nmol/mg protein, but did not compromise cell viability. During a subsequent incubation of the cells in AgNP-free medium, the cellular silver content of AgNP-treated astrocytes remained almost constant for up to 7 days. The cellular presence of AgNP did neither induce any delayed cell toxicity nor were alterations in cellular glucose consumption, lactate production or in the cellular ratio of glutathione to glutathione disulfide observed. However, Western blot analysis and immunocytochemical staining revealed that AgNP-treated astrocytes strongly upregulated the expression of metallothioneins. These results demonstrate that a prolonged presence of accumulated AgNP does not compromise the viability and the basal metabolism of cultured astrocytes and suggest that the upregulation of metallothioneins may help to prevent silver-mediated toxicity that could be induced by AgNP-derived silver ions. More... »

PAGES

1639-1648

References to SciGraph publications

  • 2009-09-17. Anti-proliferative activity of silver nanoparticles in BMC MOLECULAR AND CELL BIOLOGY
  • 2007-06-06. The Pivotal Role of Astrocytes in the Metabolism of Iron in the Brain in NEUROCHEMICAL RESEARCH
  • 2011-06-07. Chemistry and biology of mammalian metallothioneins in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11064-012-0767-4

    DOI

    http://dx.doi.org/10.1007/s11064-012-0767-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012938048

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22476984


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