Human Serotonin Transporter Expression During Megakaryocytic Differentiation of MEG-01 Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Gino Giannaccini, Laura Betti, Lionella Palego, Lara Schmid, Laura Fabbrini, Caterina Pelosini, Claudia Gargini, Ylenia Da Valle, Mario Lanza, Alessandro Marsili, Margherita Maffei, Ferruccio Santini, Paolo Vitti, Aldo Pinchera, Antonio Lucacchini

ABSTRACT

The serotonin (5-HT) transporter (SERT) has been found altered in platelets of patients with genetically complex disorders, including mood-anxiety, pain and eating disorders. In this study, we used cell cultures of platelet precursors as models of investigation on mechanisms of SERT regulation: SERT expression was appraised during megakaryocytic differentiation of human megakaryoblastic MEG-01 cells. Cells were cultured for 8 days with 10(-7)M 4-beta-12-tetradecanoylphorbol-13-acetate (beta-TPA) in the presence of 10% fetal bovine serum (FBS) and SERT was assessed by real time PCR, immunofluorescence microscopy, Western blot and [(3)H]5-HT re-uptake. Results revealed that SERT is present in control-untreated MEG-01 cells. beta-TPA-differentiating MEG-01 cells showed a redistribution of SERT fluorescence, diffuse to cell bodies and blebs along with a 3-fold SERT mRNA increase and a moderate raise in SERT protein (1.5/1.4-fold) by immunoblot and re-uptake assays. In summary, we have shown herein that control megakaryoblasts express the SERT protein. SERT is modulated by differentiation events, implying that SERT density in platelets is under the control of megakaryocytopoiesis stages. Differentiation of MEG-01 cells can provide considerable insight into interactions between SERT genetics, transmitter-hormonal/homeostatic mechanisms and signaling pathways. More... »

PAGES

628-635

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11064-009-0112-8

DOI

http://dx.doi.org/10.1007/s11064-009-0112-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041276072

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20041293


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