Modeling of Single-Walled Carbon Nanotube Binding to Nitric Oxide Synthase and Guanylate Cyclase Molecular Structures View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03

AUTHORS

V. V. Hurmach, S. V. Khrapatiy, D. O. Zavodovskyi, Yu. I. Prylutskyy, E. Täuscher, U. Ritter

ABSTRACT

Previously, we have demonstrated that water dispersible single-walled carbon nanotubes (SWCNTs) may be used in low therapeutic doses in antihypertensive therapy as promising agents capable of activating constitutive nitric oxide synthase (NOS) in spontaneously hypertensive rats, thus increasing the NO production in central and peripheral elements of the cardiovascular system [1]. Here we confirm this effect by docking and molecular dynamics simulations, clearly showing that SWCNTs may interact with NOS and guanylate cyclase molecular structures. More... »

PAGES

110-115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11062-020-09859-0

DOI

http://dx.doi.org/10.1007/s11062-020-09859-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131533774


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