Systemic Administrations of Water-Dispersible Single-Walled Carbon Nanotubes: Activation of NOS in Spontaneously Hypertensive Rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03

AUTHORS

L. M. Shapoval, O. V. Dmytrenko, V. F. Sagach, S. V. Prylutska, S. V. Khrapatiy, D. O. Zavodovskyi, Yu. I. Prylutskyy, N. Tsierkezos, U. Ritter

ABSTRACT

Priority data have been obtained on the effects of repeated systemic administrations of water-dispersible single-walled carbon nanotubes (SWCNTs) to spontaneously hypertensive rats with respect to constitutive NO-synthase (cNOS). As is known, NO is an inhibitory transmitter in the cardiovascular system. It was found that the systemic (i.p., subcutaneous, and i.m.) introductions of SWCNTs during two weeks resulted in considerable elevations of the NO2– level (a marker of NO bioavailability) in the blood of experimental hypertensive animals. Thus, SWCNTs may be used in the future for antihypertensive therapy as a novel agent capable of activating cNOS and, thus, increasing the NO production in central and peripheral elements of the cardiovascular system. More... »

PAGES

101-109

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11062-020-09858-1

DOI

http://dx.doi.org/10.1007/s11062-020-09858-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131536018


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