Transmembrane Transport and Release of GABA in the Brain of Rats Subjected to Postnatal Hypoxia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

L. N. Yatsenko, L. G. Storchak, N. T. Parkhomenko, N. H. Himmelreich

ABSTRACT

We studied the effects of early postnatal hypoxia on the efficiency of active GABA transport through the plasma membrane of synaptic terminals (synaptosomes) isolated from the cerebral cortex, hippocampus, and thalamus of rats and on non-stimulated and Ca2+-stimulated GABA release. The state of hypoxia was induced by exposure of 10- to 12-day-old rats to a respiratory medium with low O2 content (4% О2 and 96% N2) for 12 min (up to the initiation of clonico-tonic seizures). Animals were taken in the experiment 8 to 9 weeks after an episode of hypoxic stress. The intensity of transmembrane transport of GABA was estimated according to accumulation of [3Н]GABA in a coarse synaptosomal fraction. The process was characterized by calculation of the Michaelis constant Km and also of the initial (within the 1st min) and maximum rates of accumulation of [3Н]GABA. The means of the initial rate of [3Н]GABA accumulation in preparations from the thalamus, cortex, and hippocampus were 205.5 ± 8.8, 266.2 ± 29.6, and 302.3 ± 31.2 pmol/min⋅mg protein, respectively. Hypoxic stress influenced the rates of accumulation of [3Н]GABA in synaptic terminals from the cortex and hippocampus but not in those from the thalamus. According to the characteristics of the response to hypoxic stress, all experimental animals could be classified into two groups. In some rats, accumulation of [3Н]GABA in both cortical and hippocampal synaptosomes decreased insignificantly (by about 15%), while in other animals this parameter increased significantly (by nearly 50%) for the cortex and decreased by 21.5%, on average, for the hippocampus. The affinity of the transporter with respect to [3Н]GABA in the cortex and hippocampus was nearly the same and showed no changes under the influence of hypoxia. The non-stimulated release of [3Н]GABA after the influence of hypoxia increased in all structures, while the depolarization-induced Ca2+-dependent release of [3Н]GABA was intensified only in synaptosomes from the cerebral cortex. The mechanisms of development of modifications of GABA-ergic processes under the influence of hypoxic stress in the course of the perinatal period are discussed. More... »

PAGES

243-251

Journal

TITLE

Neurophysiology

ISSUE

4

VOLUME

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11062-009-9048-5

DOI

http://dx.doi.org/10.1007/s11062-009-9048-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005762860


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yatsenko", 
        "givenName": "L. N.", 
        "id": "sg:person.0766574033.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766574033.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Storchak", 
        "givenName": "L. G.", 
        "id": "sg:person.015254252667.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015254252667.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parkhomenko", 
        "givenName": "N. T.", 
        "id": "sg:person.011367461075.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367461075.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Palladin Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.419966.5", 
          "name": [
            "Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Himmelreich", 
        "givenName": "N. H.", 
        "id": "sg:person.01016527735.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016527735.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03274.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002761179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03274.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002761179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2007.01.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005036089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1098-2779(200102)7:1<56::aid-mrdd1008>3.0.co;2-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009204173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00317.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010293694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00924-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013225955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00924-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013225955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(04)00881-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016233987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91230-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017636716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(86)91230-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017636716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-328x(97)00323-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018571291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410290610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018966349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0920-1211(96)00045-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019239032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1994.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022284762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1994.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022284762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2003.08.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025189411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2003.08.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025189411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(01)02088-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027034372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(97)00684-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028282881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1998.tb01268.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028578410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1998.tb01268.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028578410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2007.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029011287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.2000.tb01576.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029305493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.2000.tb01576.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029305493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-0186(95)00158-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031806036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00787-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037074749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(86)90432-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038306758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(97)00599-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040264968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0301-0082(93)90022-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042012586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0301-0082(93)90022-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042012586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.01064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042450220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2005.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044228070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045321579", 
          "https://doi.org/10.1038/sj.cr.7290067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cr.7290067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045321579", 
          "https://doi.org/10.1038/sj.cr.7290067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/376174a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045937841", 
          "https://doi.org/10.1038/376174a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00856.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046458384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-0186(99)00046-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046555897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2006.04109.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049573026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410410210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051345728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresrev.2004.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051480619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(02)00302-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051705866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0920-1211(00)00174-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052175042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neures.2006.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052286150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(02)00358-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053003848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0034-5687(01)00306-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053148983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568007033482788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069190244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568026053386962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069193155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077201082", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.1998.79.1.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083195556"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "We studied the effects of early postnatal hypoxia on the efficiency of active GABA transport through the plasma membrane of synaptic terminals (synaptosomes) isolated from the cerebral cortex, hippocampus, and thalamus of rats and on non-stimulated and Ca2+-stimulated GABA release. The state of hypoxia was induced by exposure of 10- to 12-day-old rats to a respiratory medium with low O2 content (4% \u041e2 and 96% N2) for 12 min (up to the initiation of clonico-tonic seizures). Animals were taken in the experiment 8 to 9 weeks after an episode of hypoxic stress. The intensity of transmembrane transport of GABA was estimated according to accumulation of [3\u041d]GABA in a coarse synaptosomal fraction. The process was characterized by calculation of the Michaelis constant Km and also of the initial (within the 1st min) and maximum rates of accumulation of [3\u041d]GABA. The means of the initial rate of [3\u041d]GABA accumulation in preparations from the thalamus, cortex, and hippocampus were 205.5 \u00b1 8.8, 266.2 \u00b1 29.6, and 302.3 \u00b1 31.2 pmol/min\u22c5mg protein, respectively. Hypoxic stress influenced the rates of accumulation of [3\u041d]GABA in synaptic terminals from the cortex and hippocampus but not in those from the thalamus. According to the characteristics of the response to hypoxic stress, all experimental animals could be classified into two groups. In some rats, accumulation of [3\u041d]GABA in both cortical and hippocampal synaptosomes decreased insignificantly (by about 15%), while in other animals this parameter increased significantly (by nearly 50%) for the cortex and decreased by 21.5%, on average, for the hippocampus. The affinity of the transporter with respect to [3\u041d]GABA in the cortex and hippocampus was nearly the same and showed no changes under the influence of hypoxia. The non-stimulated release of [3\u041d]GABA after the influence of hypoxia increased in all structures, while the depolarization-induced Ca2+-dependent release of [3\u041d]GABA was intensified only in synaptosomes from the cerebral cortex. The mechanisms of development of modifications of GABA-ergic processes under the influence of hypoxic stress in the course of the perinatal period are discussed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11062-009-9048-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016854", 
        "issn": [
          "0090-2977", 
          "1573-9007"
        ], 
        "name": "Neurophysiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Transmembrane Transport and Release of GABA in the Brain of Rats Subjected to Postnatal Hypoxia", 
    "pagination": "243-251", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b74e21e0ddaf5fc66586aaade70dffd909503fde09b03b0a8ba36402b192406"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11062-009-9048-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005762860"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11062-009-9048-5", 
      "https://app.dimensions.ai/details/publication/pub.1005762860"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11062-009-9048-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11062-009-9048-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11062-009-9048-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11062-009-9048-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11062-009-9048-5'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      67 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11062-009-9048-5 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nbc741faac8684bd99cdf6e33c2e5b587
4 schema:citation sg:pub.10.1038/376174a0
5 sg:pub.10.1038/sj.cr.7290067
6 https://app.dimensions.ai/details/publication/pub.1077201082
7 https://doi.org/10.1002/1098-2779(200102)7:1<56::aid-mrdd1008>3.0.co;2-a
8 https://doi.org/10.1002/ana.410290610
9 https://doi.org/10.1002/ana.410410210
10 https://doi.org/10.1016/0003-2697(86)90432-x
11 https://doi.org/10.1016/0006-8993(86)91230-8
12 https://doi.org/10.1016/0197-0186(95)00158-1
13 https://doi.org/10.1016/0301-0082(93)90022-k
14 https://doi.org/10.1016/j.brainresrev.2004.03.003
15 https://doi.org/10.1016/j.ejphar.2003.08.063
16 https://doi.org/10.1016/j.neuint.2005.02.004
17 https://doi.org/10.1016/j.neures.2006.10.009
18 https://doi.org/10.1016/j.neuroscience.2007.01.064
19 https://doi.org/10.1016/j.neuroscience.2007.06.030
20 https://doi.org/10.1016/s0034-5687(01)00306-1
21 https://doi.org/10.1016/s0165-3806(02)00302-4
22 https://doi.org/10.1016/s0165-3806(02)00358-9
23 https://doi.org/10.1016/s0169-328x(97)00323-9
24 https://doi.org/10.1016/s0197-0186(99)00046-7
25 https://doi.org/10.1016/s0304-3940(01)02088-2
26 https://doi.org/10.1016/s0306-4522(02)00787-x
27 https://doi.org/10.1016/s0306-4522(02)00924-7
28 https://doi.org/10.1016/s0306-4522(97)00599-x
29 https://doi.org/10.1016/s0306-4522(97)00684-2
30 https://doi.org/10.1016/s0920-1211(00)00174-1
31 https://doi.org/10.1016/s0920-1211(96)00045-9
32 https://doi.org/10.1016/s1474-4422(04)00881-6
33 https://doi.org/10.1038/jcbfm.1994.35
34 https://doi.org/10.1111/j.1471-4159.2005.03274.x
35 https://doi.org/10.1111/j.1471-4159.2006.04109.x
36 https://doi.org/10.1111/j.1528-1157.1998.tb01268.x
37 https://doi.org/10.1111/j.1528-1157.2000.tb01576.x
38 https://doi.org/10.1152/jn.00317.2003
39 https://doi.org/10.1152/jn.00856.2002
40 https://doi.org/10.1152/jn.1998.79.1.73
41 https://doi.org/10.1242/jeb.01064
42 https://doi.org/10.2174/1568007033482788
43 https://doi.org/10.2174/1568026053386962
44 schema:datePublished 2008-07
45 schema:datePublishedReg 2008-07-01
46 schema:description We studied the effects of early postnatal hypoxia on the efficiency of active GABA transport through the plasma membrane of synaptic terminals (synaptosomes) isolated from the cerebral cortex, hippocampus, and thalamus of rats and on non-stimulated and Ca2+-stimulated GABA release. The state of hypoxia was induced by exposure of 10- to 12-day-old rats to a respiratory medium with low O2 content (4% О2 and 96% N2) for 12 min (up to the initiation of clonico-tonic seizures). Animals were taken in the experiment 8 to 9 weeks after an episode of hypoxic stress. The intensity of transmembrane transport of GABA was estimated according to accumulation of [3Н]GABA in a coarse synaptosomal fraction. The process was characterized by calculation of the Michaelis constant Km and also of the initial (within the 1st min) and maximum rates of accumulation of [3Н]GABA. The means of the initial rate of [3Н]GABA accumulation in preparations from the thalamus, cortex, and hippocampus were 205.5 ± 8.8, 266.2 ± 29.6, and 302.3 ± 31.2 pmol/min⋅mg protein, respectively. Hypoxic stress influenced the rates of accumulation of [3Н]GABA in synaptic terminals from the cortex and hippocampus but not in those from the thalamus. According to the characteristics of the response to hypoxic stress, all experimental animals could be classified into two groups. In some rats, accumulation of [3Н]GABA in both cortical and hippocampal synaptosomes decreased insignificantly (by about 15%), while in other animals this parameter increased significantly (by nearly 50%) for the cortex and decreased by 21.5%, on average, for the hippocampus. The affinity of the transporter with respect to [3Н]GABA in the cortex and hippocampus was nearly the same and showed no changes under the influence of hypoxia. The non-stimulated release of [3Н]GABA after the influence of hypoxia increased in all structures, while the depolarization-induced Ca2+-dependent release of [3Н]GABA was intensified only in synaptosomes from the cerebral cortex. The mechanisms of development of modifications of GABA-ergic processes under the influence of hypoxic stress in the course of the perinatal period are discussed.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N33d25801554c4feb86b125083389f34d
51 Nba8bf9cc67274bcc8365feaeaa12b3ac
52 sg:journal.1016854
53 schema:name Transmembrane Transport and Release of GABA in the Brain of Rats Subjected to Postnatal Hypoxia
54 schema:pagination 243-251
55 schema:productId N8d6e220ad9a747b98c02d533316b63d3
56 N9914c1682b594ab2939c86546f729551
57 Nbaa0d0fd6ef1471db69f38dba8ed97f8
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005762860
59 https://doi.org/10.1007/s11062-009-9048-5
60 schema:sdDatePublished 2019-04-10T18:20
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N83d87e101958496a910f043bb67b63d8
63 schema:url http://link.springer.com/10.1007%2Fs11062-009-9048-5
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0c62f28ba9174c5aaf801939c7fe5e82 rdf:first sg:person.01016527735.99
68 rdf:rest rdf:nil
69 N33d25801554c4feb86b125083389f34d schema:volumeNumber 40
70 rdf:type schema:PublicationVolume
71 N5db6475d88e145a283119a86d171c06c rdf:first sg:person.011367461075.84
72 rdf:rest N0c62f28ba9174c5aaf801939c7fe5e82
73 N83d87e101958496a910f043bb67b63d8 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N8d6e220ad9a747b98c02d533316b63d3 schema:name readcube_id
76 schema:value 1b74e21e0ddaf5fc66586aaade70dffd909503fde09b03b0a8ba36402b192406
77 rdf:type schema:PropertyValue
78 N9914c1682b594ab2939c86546f729551 schema:name doi
79 schema:value 10.1007/s11062-009-9048-5
80 rdf:type schema:PropertyValue
81 Na27df1d281e746c3b458ce1d457918aa rdf:first sg:person.015254252667.00
82 rdf:rest N5db6475d88e145a283119a86d171c06c
83 Nba8bf9cc67274bcc8365feaeaa12b3ac schema:issueNumber 4
84 rdf:type schema:PublicationIssue
85 Nbaa0d0fd6ef1471db69f38dba8ed97f8 schema:name dimensions_id
86 schema:value pub.1005762860
87 rdf:type schema:PropertyValue
88 Nbc741faac8684bd99cdf6e33c2e5b587 rdf:first sg:person.0766574033.66
89 rdf:rest Na27df1d281e746c3b458ce1d457918aa
90 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
91 schema:name Medical and Health Sciences
92 rdf:type schema:DefinedTerm
93 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
94 schema:name Neurosciences
95 rdf:type schema:DefinedTerm
96 sg:journal.1016854 schema:issn 0090-2977
97 1573-9007
98 schema:name Neurophysiology
99 rdf:type schema:Periodical
100 sg:person.01016527735.99 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
101 schema:familyName Himmelreich
102 schema:givenName N. H.
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016527735.99
104 rdf:type schema:Person
105 sg:person.011367461075.84 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
106 schema:familyName Parkhomenko
107 schema:givenName N. T.
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367461075.84
109 rdf:type schema:Person
110 sg:person.015254252667.00 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
111 schema:familyName Storchak
112 schema:givenName L. G.
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015254252667.00
114 rdf:type schema:Person
115 sg:person.0766574033.66 schema:affiliation https://www.grid.ac/institutes/grid.419966.5
116 schema:familyName Yatsenko
117 schema:givenName L. N.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766574033.66
119 rdf:type schema:Person
120 sg:pub.10.1038/376174a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045937841
121 https://doi.org/10.1038/376174a0
122 rdf:type schema:CreativeWork
123 sg:pub.10.1038/sj.cr.7290067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045321579
124 https://doi.org/10.1038/sj.cr.7290067
125 rdf:type schema:CreativeWork
126 https://app.dimensions.ai/details/publication/pub.1077201082 schema:CreativeWork
127 https://doi.org/10.1002/1098-2779(200102)7:1<56::aid-mrdd1008>3.0.co;2-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009204173
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1002/ana.410290610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018966349
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1002/ana.410410210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051345728
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1016/0003-2697(86)90432-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038306758
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1016/0006-8993(86)91230-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017636716
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1016/0197-0186(95)00158-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031806036
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/0301-0082(93)90022-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1042012586
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/j.brainresrev.2004.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051480619
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/j.ejphar.2003.08.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025189411
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/j.neuint.2005.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044228070
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/j.neures.2006.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052286150
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1016/j.neuroscience.2007.01.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005036089
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1016/j.neuroscience.2007.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029011287
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1016/s0034-5687(01)00306-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053148983
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/s0165-3806(02)00302-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051705866
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s0165-3806(02)00358-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053003848
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0169-328x(97)00323-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018571291
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0197-0186(99)00046-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046555897
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0304-3940(01)02088-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027034372
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0306-4522(02)00787-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037074749
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/s0306-4522(02)00924-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013225955
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/s0306-4522(97)00599-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040264968
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/s0306-4522(97)00684-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028282881
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/s0920-1211(00)00174-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052175042
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/s0920-1211(96)00045-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019239032
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/s1474-4422(04)00881-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016233987
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1038/jcbfm.1994.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022284762
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1111/j.1471-4159.2005.03274.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002761179
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/j.1471-4159.2006.04109.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049573026
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/j.1528-1157.1998.tb01268.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028578410
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1111/j.1528-1157.2000.tb01576.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029305493
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1152/jn.00317.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010293694
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1152/jn.00856.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046458384
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1152/jn.1998.79.1.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083195556
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1242/jeb.01064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042450220
196 rdf:type schema:CreativeWork
197 https://doi.org/10.2174/1568007033482788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069190244
198 rdf:type schema:CreativeWork
199 https://doi.org/10.2174/1568026053386962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193155
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.419966.5 schema:alternateName Palladin Institute of Biochemistry
202 schema:name Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...