Prognostic factors for brain metastasis in women presenting cervical cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-14

AUTHORS

Juliana de Brito Rangel, Alessandra Grasso Giglio, Cristiane Lemos Cardozo, Anke Bergmann, Luiz Claudio Santos Thuler

ABSTRACT

PurposeAlthough rare, brain metastases (BM) from cervical cancer (CC) are highly lethal. Adequate patient selection for specific treatments can improve survival rates in patients afflicted by this condition. This study aimed to describe the characteristics of CC patients who developed BM and overall survival-associated factors. Brain metastasis impact on the overall survival was assessed as a secondary objective.MethodsThis assessment comprises a retrospective cohort study on 3394 women presenting CC diagnosed between January 2010 and December 2017 at a single referral center. Incident BM cases were included. Descriptive statistics were calculated. Kaplan–Meier curves were used for the survival analysis and a Cox proportional hazards regression model was applied to explore the risk of death according to the analyzed independent variables.ResultsA total of 48 incident BM cases were identified. The median time between CC diagnosis and BM development was 1.5 years. Headaches (29.2%), dizziness/altered balance (29.2%), vertigo (29.2%) and motor disturbances (25.0%) were the most common signs and symptoms at presentation. Median overall survival after BM diagnosis was of 1.6 months (95% CI 0.9–2.3) while in the group of women without BM it was 5.5 years (95% CI 4.9–6.1). Concerning the Cox multivariate analysis, presenting one extracerebral metastases site (HR 2.8; 95% CI 1.3–6.2; p = 0.009) and receiving supportive treatment (HR 13.7; 95% CI 3.1–60.5; p 0.001) were independently associated with the risk of death.ConclusionThe median survival of women with BM following CC was poor. Women without extracerebral metastases and undergoing multimodal treatment displayed better overall survival rates. More... »

PAGES

469-477

References to SciGraph publications

  • 2008-12-16. Purposeful selection of variables in logistic regression in SOURCE CODE FOR BIOLOGY AND MEDICINE
  • 2011-10-20. Epidemiology of Brain Metastases in CURRENT ONCOLOGY REPORTS
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    http://scigraph.springernature.com/pub.10.1007/s11060-022-04082-9

    DOI

    http://dx.doi.org/10.1007/s11060-022-04082-9

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    https://app.dimensions.ai/details/publication/pub.1149470715

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35834147


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