Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-12

AUTHORS

Mario Ganau, Ismail Zaed, Julien Todeschi, Laura Prisco, Helene Cebula, Carmen Bruno, Giorgio Spatola, Gianfranco K. I. Ligarotti, Raffaele Alessandrello, Marco Fricia, Antonio Romano, Raoul Pop, Seyyid Baloglu, Luciano Savarese, Antonino Scibilia, Beniamino Nannavecchia, Francois Proust, Salvatore Chibbaro

ABSTRACT

IntroductionTo date, confined intra-ventricular localization of primary central nervous system lymphoma (PCNSL) has been usually managed with open surgical resection and/or stereotactic biopsy; nonetheless, the endoscopic approach to such localization can provide many advantages over standard microsurgery and/or stereotactic biopsy. Here we present our experience in managing such a rare pathology through the endoscopic approach.MethodIn order to gather more information about such a rare pathology, a retrospective multicentric study on a prospectively built database has been performed during a 5 year period. Ten different European centers have been involved.ResultsA total of 60 patients, 25 women and 35 men, have been enrolled in the study. The mean age was 65.3 years. The mean lesion size was 40.3 mm. Among all selected patients, 40 (66.6%) had superficial lesions within the ventricle, whereas the remaining 20 (33.4%) had lesions involving/extending to deeper structures. All surgical procedures were uneventful and ETV was deemed necessary only in 20/60 cases.ConclusionIn our experience, endoscopic management of intraventricular PCNSL is an effective option. It should be considered after a careful examination of neurological and immunological status, alternative options for diagnostic sampling, location of the lesion, and presence or absence of hydrocephalus. Endoscopic management could be considered as a safe and minimally invasive option to obtain: (a) a biopsy sample of the lesion for further diagnostic workup, (b) CSF diversion through third ventriculostomy or VP shunt for the management of hydrocephalus, and (c) insertion of ventricular access devices for long term medical management and whenever necessary as a rescue option for ventricular tap. More... »

PAGES

1-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-022-04081-w

DOI

http://dx.doi.org/10.1007/s11060-022-04081-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149440944

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35829848


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14 schema:description IntroductionTo date, confined intra-ventricular localization of primary central nervous system lymphoma (PCNSL) has been usually managed with open surgical resection and/or stereotactic biopsy; nonetheless, the endoscopic approach to such localization can provide many advantages over standard microsurgery and/or stereotactic biopsy. Here we present our experience in managing such a rare pathology through the endoscopic approach.MethodIn order to gather more information about such a rare pathology, a retrospective multicentric study on a prospectively built database has been performed during a 5 year period. Ten different European centers have been involved.ResultsA total of 60 patients, 25 women and 35 men, have been enrolled in the study. The mean age was 65.3 years. The mean lesion size was 40.3 mm. Among all selected patients, 40 (66.6%) had superficial lesions within the ventricle, whereas the remaining 20 (33.4%) had lesions involving/extending to deeper structures. All surgical procedures were uneventful and ETV was deemed necessary only in 20/60 cases.ConclusionIn our experience, endoscopic management of intraventricular PCNSL is an effective option. It should be considered after a careful examination of neurological and immunological status, alternative options for diagnostic sampling, location of the lesion, and presence or absence of hydrocephalus. Endoscopic management could be considered as a safe and minimally invasive option to obtain: (a) a biopsy sample of the lesion for further diagnostic workup, (b) CSF diversion through third ventriculostomy or VP shunt for the management of hydrocephalus, and (c) insertion of ventricular access devices for long term medical management and whenever necessary as a rescue option for ventricular tap.
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20 schema:keywords CSF diversion
21 ConclusionIn
22 ETV
23 European Centre
24 IntroductionTo date
25 MethodIn
26 ResultsA total
27 VP shunt
28 absence
29 absence of hydrocephalus
30 access devices
31 advantages
32 age
33 alternative option
34 approach
35 biopsy
36 biopsy samples
37 careful examination
38 cases
39 center
40 central nervous system lymphoma
41 database
42 date
43 deep structure
44 devices
45 diagnostic sampling
46 diagnostic workup
47 different European centres
48 diversion
49 effective option
50 efficacy
51 endoscopic approach
52 endoscopic management
53 examination
54 experience
55 further diagnostic workup
56 hydrocephalus
57 immunological status
58 information
59 insertion
60 invasive option
61 lesion size
62 lesions
63 literature review
64 localization
65 location
66 long-term medical management
67 lymphoma
68 management
69 management of hydrocephalus
70 mean age
71 mean lesion size
72 medical management
73 men
74 microsurgery
75 more information
76 multicentric study
77 nervous system lymphoma
78 open surgical resection
79 options
80 pathology
81 patients
82 period
83 presence
84 primary central nervous system lymphoma
85 procedure
86 rare pathology
87 rescue option
88 resection
89 retrospective multicentric study
90 review
91 samples
92 sampling
93 shunt
94 size
95 standard microsurgery
96 status
97 stereotactic biopsy
98 structure
99 study
100 such localization
101 superficial lesions
102 surgical procedures
103 surgical resection
104 system lymphoma
105 tap
106 third ventriculostomy
107 total
108 ventricle
109 ventricular access device
110 ventricular tap
111 ventriculostomy
112 women
113 workup
114 year period
115 years
116 schema:name Efficacy of endoscopic management of primary central nervous system lymphoma: a multicentric study and literature review
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