How ten-years of reirradiation for paediatric high-grade glioma may shed light on first line treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-09

AUTHORS

Maura Massimino, Sabina Vennarini, Francesco Barretta, Francesca Colombo, Manila Antonelli, Bianca Pollo, Emanuele Pignoli, Emilia Pecori, Ombretta Alessandro, Elisabetta Schiavello, Luna Boschetti, Marta Podda, Nadia Puma, Giovanna Gattuso, Giovanna Sironi, Elena Barzanò, Olga Nigro, Luca Bergamaschi, Stefano Chiaravalli, Roberto Luksch, Cristina Meazza, Filippo Spreafico, Monica Terenziani, Michela Casanova, Andrea Ferrari, Marco Chisari, Chiara Pellegrini, Carlo Alfredo Clerici, Piergiorgio Modena, Veronica Biassoni

ABSTRACT

PurposeRecurrence incidence for paediatric/adolescent high-grade glioma (HGG) exceeds 80%. Reirradiation (reRT) palliates symptoms and delays further progression. Strategies for reRT are scarce: we retrospectively analysed our series to develop rational future approaches.MethodsWe re-evaluated MRI + RT plans of 21 relapsed HGG-patients, accrued 2010–2021, aged under 18 years. All underwent surgery and RT + chemotherapy at diagnosis. Pathologic/molecular re-evaluation allowed classification based on WHO 2021 criteria in 20/21 patients. Survival analyses and association with clinical parameters were performed.ResultsRelapse after 1st RT was local in 12 (7 marginal), 4 disseminated, 5 local + disseminated. Re-RT obtained 8 SD, 1 PR, 1PsPD, 1 mixed response, 10 PD; neurological signs/symptoms improved in 8. Local reRT was given to 12, followed again by 6 local (2 marginal) and 4 local + disseminated second relapses in 10/12 re-evaluated. The 4 with dissemination had 1 whole brain, 2 craniospinal irradiation (CSI), 1 spine reRT and further relapsed with dissemination and local + dissemination in 3/four assessed. Five local + disseminated tumours had 3 CSI, 1 spine reRT, further progressing locally (2), disseminated (1), n.a. (1). Three had a third RT; three were alive at 19.4, 29, 50.3 months after diagnosis. Median times to progression/survival after re-RT were 3.7 months (0.6–16.2 months)/6.9 months (0.6–17.9 months), improved for longer interval between 1st RT and re-RT (P = 0.017) and for non-PD after reRT (P < 0.001). First marginal relapse showed potential association with dissemination after re-RT (P = 0.081).ConclusionsThis is the biggest series of re-RT in paediatric HGG. Considering the dissemination observed at relapse, our results could prompt the investigation of different first RT fields in a randomized trial. More... »

PAGES

437-445

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-022-04079-4

    DOI

    http://dx.doi.org/10.1007/s11060-022-04079-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149357796

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35809148


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