Ventricular opening and cerebrospinal fluid circulation accelerate the biodegradation process of carmustine wafers suggesting their immunomodulation potential in the human ... View Full Text


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Article Info

DATE

2022-07-08

AUTHORS

Ichiyo Shibahara, Yukiko Shibahara, Hiroyuki Hagiwara, Takashi Watanabe, Yasushi Orihashi, Hajime Handa, Madoka Inukai, Takuichiro Hide, Yoshie Yasui, Toshihiro Kumabe

ABSTRACT

PurposeOpening the ventricular system during glioblastoma surgery is often necessary, but the consequent effect on the tumor microenvironment of glioblastoma remains unknown. Implantation of carmustine wafer enables direct drug delivery to the tumor site; however, the exact mechanism of the wafer’s biodegradation process is unclear, and the available data is limited to in vivo non-human mammalian studies. We hypothesized that the ventricular opening affects the degradation process of the wafer and the glioblastoma tumor microenvironment. MethodsThis study included 30 glioblastoma patients. 21 patients underwent carmustine wafer implantation during initial surgery. All patients underwent repeated surgical resection upon recurrence, allowing for pathological comparison of changes associated with wafer implantation. Immunohistochemical analyses were performed using CD68, TMEM119, CD163, IBA1, BIN1, and CD31 antibodies to highlight microglia, macrophages, and tumor vascularity, and the quantitative scoring results were correlated with clinical, molecular, and surgical variables, including the effect of the ventricular opening.ResultsThe carmustine wafer implanted group presented significantly less TMEM119-positive microglia within the tumor (P = 0.0002). Simple and multiple regression analyses revealed that the decrease in TMEM119-positive microglia was correlated with longer intervals between surgeries and opened ventricular systems. No correlation was observed between age, methylated O6-methylguanine DNA methyltransferase promoter expression, and the extent of surgical resection.ConclusionsOur study findings strongly suggest that biomaterials may possess immunomodulation capacity, which is significantly impacted by the ventricular opening procedure. Furthermore, our data highlights the pathophysiological effects of the ventricular opening within the surrounding human brain, especially after the wafer implantation. More... »

PAGES

425-435

References to SciGraph publications

  • 1995-11. The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase I trial in JOURNAL OF NEURO-ONCOLOGY
  • 2017-05-22. Opening the ventricle during surgery diminishes survival among patients with newly diagnosed glioblastoma treated with carmustine wafers: a multi-center retrospective study in JOURNAL OF NEURO-ONCOLOGY
  • 2017-12-20. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment in GENOME BIOLOGY
  • 2010-03-16. O6-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2016-08-22. Sex differences in immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2010-05-05. Biodegradable Carmustine Wafers (Gliadel) Alone or in Combination with Chemoradiotherapy: The French Experience in ANNALS OF SURGICAL ONCOLOGY
  • 2015-07-15. Development and functions of the choroid plexus–cerebrospinal fluid system in NATURE REVIEWS NEUROSCIENCE
  • 2014-04-01. Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma in BRITISH JOURNAL OF CANCER
  • 2018-02-21. Tumor microenvironment after biodegradable BCNU wafer implantation: special consideration of immune system in JOURNAL OF NEURO-ONCOLOGY
  • 2017-12-04. QuPath: Open source software for digital pathology image analysis in SCIENTIFIC REPORTS
  • 2020-07-27. TMEM119 as a specific marker of microglia reaction in traumatic brain injury in postmortem examination in INTERNATIONAL JOURNAL OF LEGAL MEDICINE
  • 2004-02. Pattern of Recurrence following Local Chemotherapy with Biodegradable Carmustine (BCNU) Implants in Patients with Glioblastoma in JOURNAL OF NEURO-ONCOLOGY
  • 2008-07-18. Use of Gliadel (BCNU) Wafer in the Surgical Treatment of Malignant Glioma: A 10-Year Institutional Experience in ANNALS OF SURGICAL ONCOLOGY
  • 2015-12-29. The role of microglia and macrophages in glioma maintenance and progression in NATURE NEUROSCIENCE
  • 1996-05. Morphological Characterization of Polyanhydride Biodegradable Implant Gliadel® During in Vitro and in Vivo Erosion Using Scanning Electron Microscopy in PHARMACEUTICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-022-04078-5

    DOI

    http://dx.doi.org/10.1007/s11060-022-04078-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149334943

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35802230


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    29 schema:description PurposeOpening the ventricular system during glioblastoma surgery is often necessary, but the consequent effect on the tumor microenvironment of glioblastoma remains unknown. Implantation of carmustine wafer enables direct drug delivery to the tumor site; however, the exact mechanism of the wafer’s biodegradation process is unclear, and the available data is limited to in vivo non-human mammalian studies. We hypothesized that the ventricular opening affects the degradation process of the wafer and the glioblastoma tumor microenvironment. MethodsThis study included 30 glioblastoma patients. 21 patients underwent carmustine wafer implantation during initial surgery. All patients underwent repeated surgical resection upon recurrence, allowing for pathological comparison of changes associated with wafer implantation. Immunohistochemical analyses were performed using CD68, TMEM119, CD163, IBA1, BIN1, and CD31 antibodies to highlight microglia, macrophages, and tumor vascularity, and the quantitative scoring results were correlated with clinical, molecular, and surgical variables, including the effect of the ventricular opening.ResultsThe carmustine wafer implanted group presented significantly less TMEM119-positive microglia within the tumor (P = 0.0002). Simple and multiple regression analyses revealed that the decrease in TMEM119-positive microglia was correlated with longer intervals between surgeries and opened ventricular systems. No correlation was observed between age, methylated O6-methylguanine DNA methyltransferase promoter expression, and the extent of surgical resection.ConclusionsOur study findings strongly suggest that biomaterials may possess immunomodulation capacity, which is significantly impacted by the ventricular opening procedure. Furthermore, our data highlights the pathophysiological effects of the ventricular opening within the surrounding human brain, especially after the wafer implantation.
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