Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-02

AUTHORS

Hayato Suzuki, Takahiro Ono, Souichi Koyota, Masataka Takahashi, Tamotsu Sugai, Hiroshi Nanjo, Hiroaki Shimizu

ABSTRACT

PurposeIDH-wildtype (IDHwt) diffuse gliomas are treated as glioblastoma, however, some of these may show less aggressive clinical courses. The authors investigated the clinical, histopathological, and molecular characteristics of such IDHwt indolent diffuse gliomas (iDGwt), which have not been well documented in the literature.MethodsAdult patients with IDHwt gliomas admitted between 2011 and 2020 were surveyed. In this particular study, the clinical indolence was defined mainly as having a small enhancing lesion and a stable period for more than 1 month before surgery. The current WHO diagnostic criteria were adapted for the diagnoses. Gene mutations and copy number changes in 43 representative glioma-associated genes, MGMT promoter methylation status, and survival data were compared with those of The Cancer Genome Atlas reference cohort.ResultsNine out of 180 surveyed cases (5.0%) fulfilled the present criteria of the iDGwt. Considering the representative regulatory pathways, 8 (88.9%), 4 (44.4%), and 1 (11.1%) case had genetic alterations in the PI3K/MAPK, TP53, and RB pathways, respectively. The frequency of the RB pathway alteration was significantly lower than that in the reference cohort (281 of 362 cases: 77.6%). Two cases (22.2%) showing EGFR amplification met the diagnostic criteria for glioblastoma, and the frequency was significantly lower than that in the reference cohort (412 of 426 cases: 96.7%). The overall survival (median: 37.5 months) in the present series was significantly longer than that in the reference cohort (n = 426, median: 13.9 months).ConclusionsiDGwt lacked the molecular features of glioblastoma except for the PI3K/MAPK pathway alteration. More... »

PAGES

397-408

References to SciGraph publications

  • 2021-10-12. Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers in GENOME MEDICINE
  • 2015-04-13. Mutational landscape and clonal architecture in grade II and III gliomas in NATURE GENETICS
  • 2015-12-15. Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets in ACTA NEUROPATHOLOGICA
  • 2019-02-11. Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma in NATURE MEDICINE
  • 2018-09-05. Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma in ACTA NEUROPATHOLOGICA
  • 1977-01. Computed tomography in the diagnosis and differential diagnosis of glioblastomas in NEURORADIOLOGY
  • 2018-03-14. DNA methylation-based classification of central nervous system tumours in NATURE
  • 2017-04-11. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers in ACTA NEUROPATHOLOGICA
  • 2018-04-23. Novel, improved grading system(s) for IDH-mutant astrocytic gliomas in ACTA NEUROPATHOLOGICA
  • 2017-04-19. Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden in GENOME MEDICINE
  • 2017-05-17. Defining optimal cutoff value of MGMT promoter methylation by ROC analysis for clinical setting in glioblastoma patients in JOURNAL OF NEURO-ONCOLOGY
  • 2017-05-08. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients in NATURE MEDICINE
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2019-09-28. Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course in ACTA NEUROPATHOLOGICA
  • 2014-04-19. Development of a robust and sensitive pyrosequencing assay for the detection of IDH1/2 mutations in gliomas in BRAIN TUMOR PATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-022-04074-9

    DOI

    http://dx.doi.org/10.1007/s11060-022-04074-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149182764

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35779193


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioblastoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Isocitrate Dehydrogenase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylinositol 3-Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Hayato", 
            "id": "sg:person.014317055643.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317055643.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ono", 
            "givenName": "Takahiro", 
            "id": "sg:person.015733176664.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015733176664.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Medicine Laboratory, Bioscience Education and Research Support Center, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "Molecular Medicine Laboratory, Bioscience Education and Research Support Center, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koyota", 
            "givenName": "Souichi", 
            "id": "sg:person.0757104023.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757104023.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Masataka", 
            "id": "sg:person.0615710140.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615710140.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, 028-3694, Iwate, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411790.a", 
              "name": [
                "Department of Pathology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, 028-3694, Iwate, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugai", 
            "givenName": "Tamotsu", 
            "id": "sg:person.01372162736.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372162736.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Pathology, Akita University Hospital, 44-2 Hasunuma Hiroomote, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411403.3", 
              "name": [
                "Department of Surgical Pathology, Akita University Hospital, 44-2 Hasunuma Hiroomote, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nanjo", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01234057223.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234057223.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimizu", 
            "givenName": "Hiroaki", 
            "id": "sg:person.01307650417.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307650417.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00401-015-1519-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014983828", 
              "https://doi.org/10.1007/s00401-015-1519-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-017-1710-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084768901", 
              "https://doi.org/10.1007/s00401-017-1710-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-017-0424-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084826380", 
              "https://doi.org/10.1186/s13073-017-0424-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1849-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103604946", 
              "https://doi.org/10.1007/s00401-018-1849-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1905-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106679483", 
              "https://doi.org/10.1007/s00401-018-1905-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007363870", 
              "https://doi.org/10.1038/ng.3273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-021-00979-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1141826099", 
              "https://doi.org/10.1186/s13073-021-00979-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-019-02078-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1121371100", 
              "https://doi.org/10.1007/s00401-019-02078-w"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0337-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112059795", 
              "https://doi.org/10.1038/s41591-018-0337-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-017-2433-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085430606", 
              "https://doi.org/10.1007/s11060-017-2433-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature26000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101533700", 
              "https://doi.org/10.1038/nature26000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085214027", 
              "https://doi.org/10.1038/nm.4333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-014-0186-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000403235", 
              "https://doi.org/10.1007/s10014-014-0186-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00496983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029931732", 
              "https://doi.org/10.1007/bf00496983"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-07-02", 
        "datePublishedReg": "2022-07-02", 
        "description": "PurposeIDH-wildtype (IDHwt) diffuse gliomas are treated as glioblastoma, however, some of these may show less aggressive clinical courses. The authors investigated the clinical, histopathological, and molecular characteristics of such IDHwt indolent diffuse gliomas (iDGwt), which have not been well documented in the literature.MethodsAdult patients with IDHwt gliomas admitted between 2011 and 2020 were surveyed. In this particular study, the clinical indolence was defined mainly as having a small enhancing lesion and a stable period for more than 1\u00a0month before surgery. The current WHO diagnostic criteria were adapted for the diagnoses. Gene mutations and copy number changes in 43 representative glioma-associated genes, MGMT promoter methylation status, and survival data were compared with those of The Cancer Genome Atlas reference cohort.ResultsNine out of 180 surveyed cases (5.0%) fulfilled the present criteria of the iDGwt. Considering the representative regulatory pathways, 8 (88.9%), 4 (44.4%), and 1 (11.1%) case had genetic alterations in the PI3K/MAPK, TP53, and RB pathways, respectively. The frequency of the RB pathway alteration was significantly lower than that in the reference cohort (281 of 362 cases: 77.6%). Two cases (22.2%) showing EGFR amplification met the diagnostic criteria for glioblastoma, and the frequency was significantly lower than that in the reference cohort (412 of 426 cases: 96.7%). The overall survival (median: 37.5\u00a0months) in the present series was significantly longer than that in the reference cohort (n\u2009=\u2009426, median: 13.9\u00a0months).ConclusionsiDGwt lacked the molecular features of glioblastoma except for the PI3K/MAPK pathway alteration.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11060-022-04074-9", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8420184", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1094205", 
            "issn": [
              "0167-594X", 
              "1573-7373"
            ], 
            "name": "Journal of Neuro-Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "159"
          }
        ], 
        "keywords": [
          "reference cohort", 
          "diffuse gliomas", 
          "diagnostic criteria", 
          "pathway alterations", 
          "aggressive clinical course", 
          "MAPK pathway alterations", 
          "Rb pathway alterations", 
          "molecular features", 
          "MGMT promoter methylation status", 
          "clinical indolence", 
          "MethodsAdult patients", 
          "overall survival", 
          "clinical course", 
          "promoter methylation status", 
          "PI3K/MAPK", 
          "typical glioblastoma", 
          "gliomas", 
          "cohort", 
          "EGFR amplification", 
          "present series", 
          "gene mutations", 
          "glioblastoma", 
          "survival data", 
          "genetic alterations", 
          "Rb pathway", 
          "IDHwt gliomas", 
          "molecular characteristics", 
          "methylation status", 
          "alterations", 
          "regulatory pathways", 
          "ResultsNine", 
          "patients", 
          "surgery", 
          "lesions", 
          "number changes", 
          "present criteria", 
          "pathway", 
          "diagnosis", 
          "criteria", 
          "cases", 
          "months", 
          "TP53", 
          "survival", 
          "MAPK", 
          "status", 
          "stable period", 
          "mutations", 
          "course", 
          "frequency", 
          "period", 
          "study", 
          "genes", 
          "particular study", 
          "indolence", 
          "features", 
          "changes", 
          "amplification", 
          "literature", 
          "data", 
          "comparison", 
          "series", 
          "authors", 
          "characteristics"
        ], 
        "name": "Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma", 
        "pagination": "397-408", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1149182764"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11060-022-04074-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35779193"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11060-022-04074-9", 
          "https://app.dimensions.ai/details/publication/pub.1149182764"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:08", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_936.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11060-022-04074-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-022-04074-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-022-04074-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-022-04074-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-022-04074-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    276 TRIPLES      21 PREDICATES      113 URIs      90 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11060-022-04074-9 schema:about N07df147356864915901d5b905ae28a01
    2 N0bee50a5a0af4421b3b403a44ef24895
    3 N1ea2cecf0f9043339e93977e56f8e861
    4 N606bb2fbc47a4e7c91d8ba6daad68065
    5 N664a074f62ff4b8e829eb922bf2f112b
    6 N82eac67882df4dea8db4ccc1ff9e6cc4
    7 Nabab91e3261348a6b0e37b5cce03055a
    8 Nbb67a924b3624b9ebbbb00b39cd2d3d7
    9 Nc41fd80529034a68b18e18e48a5e38c2
    10 Nefde3a20cf344defac3219c247d54b98
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author N5059f0d700a54d828383795623123c41
    14 schema:citation sg:pub.10.1007/bf00496983
    15 sg:pub.10.1007/s00401-015-1519-8
    16 sg:pub.10.1007/s00401-017-1710-1
    17 sg:pub.10.1007/s00401-018-1849-4
    18 sg:pub.10.1007/s00401-018-1905-0
    19 sg:pub.10.1007/s00401-019-02078-w
    20 sg:pub.10.1007/s10014-014-0186-0
    21 sg:pub.10.1007/s11060-017-2433-9
    22 sg:pub.10.1038/bmt.2012.244
    23 sg:pub.10.1038/nature26000
    24 sg:pub.10.1038/ng.3273
    25 sg:pub.10.1038/nm.4333
    26 sg:pub.10.1038/s41591-018-0337-7
    27 sg:pub.10.1186/s13073-017-0424-2
    28 sg:pub.10.1186/s13073-021-00979-8
    29 schema:datePublished 2022-07-02
    30 schema:datePublishedReg 2022-07-02
    31 schema:description PurposeIDH-wildtype (IDHwt) diffuse gliomas are treated as glioblastoma, however, some of these may show less aggressive clinical courses. The authors investigated the clinical, histopathological, and molecular characteristics of such IDHwt indolent diffuse gliomas (iDGwt), which have not been well documented in the literature.MethodsAdult patients with IDHwt gliomas admitted between 2011 and 2020 were surveyed. In this particular study, the clinical indolence was defined mainly as having a small enhancing lesion and a stable period for more than 1 month before surgery. The current WHO diagnostic criteria were adapted for the diagnoses. Gene mutations and copy number changes in 43 representative glioma-associated genes, MGMT promoter methylation status, and survival data were compared with those of The Cancer Genome Atlas reference cohort.ResultsNine out of 180 surveyed cases (5.0%) fulfilled the present criteria of the iDGwt. Considering the representative regulatory pathways, 8 (88.9%), 4 (44.4%), and 1 (11.1%) case had genetic alterations in the PI3K/MAPK, TP53, and RB pathways, respectively. The frequency of the RB pathway alteration was significantly lower than that in the reference cohort (281 of 362 cases: 77.6%). Two cases (22.2%) showing EGFR amplification met the diagnostic criteria for glioblastoma, and the frequency was significantly lower than that in the reference cohort (412 of 426 cases: 96.7%). The overall survival (median: 37.5 months) in the present series was significantly longer than that in the reference cohort (n = 426, median: 13.9 months).ConclusionsiDGwt lacked the molecular features of glioblastoma except for the PI3K/MAPK pathway alteration.
    32 schema:genre article
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N2c874eaed25f479381d07e2297786398
    35 Nb37929db0fab4ea1b1688e94b6a46a44
    36 sg:journal.1094205
    37 schema:keywords EGFR amplification
    38 IDHwt gliomas
    39 MAPK
    40 MAPK pathway alterations
    41 MGMT promoter methylation status
    42 MethodsAdult patients
    43 PI3K/MAPK
    44 Rb pathway
    45 Rb pathway alterations
    46 ResultsNine
    47 TP53
    48 aggressive clinical course
    49 alterations
    50 amplification
    51 authors
    52 cases
    53 changes
    54 characteristics
    55 clinical course
    56 clinical indolence
    57 cohort
    58 comparison
    59 course
    60 criteria
    61 data
    62 diagnosis
    63 diagnostic criteria
    64 diffuse gliomas
    65 features
    66 frequency
    67 gene mutations
    68 genes
    69 genetic alterations
    70 glioblastoma
    71 gliomas
    72 indolence
    73 lesions
    74 literature
    75 methylation status
    76 molecular characteristics
    77 molecular features
    78 months
    79 mutations
    80 number changes
    81 overall survival
    82 particular study
    83 pathway
    84 pathway alterations
    85 patients
    86 period
    87 present criteria
    88 present series
    89 promoter methylation status
    90 reference cohort
    91 regulatory pathways
    92 series
    93 stable period
    94 status
    95 study
    96 surgery
    97 survival
    98 survival data
    99 typical glioblastoma
    100 schema:name Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma
    101 schema:pagination 397-408
    102 schema:productId N7a26cb50aab44e9b946c138cf2829205
    103 Na7a23e2195044ac0a9366514abb850de
    104 Nd909ec6560f143f1929da04423246ca0
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1149182764
    106 https://doi.org/10.1007/s11060-022-04074-9
    107 schema:sdDatePublished 2022-11-24T21:08
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher Ne036a52930b144e8a09c30ef1805b31e
    110 schema:url https://doi.org/10.1007/s11060-022-04074-9
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N07df147356864915901d5b905ae28a01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Adult
    116 rdf:type schema:DefinedTerm
    117 N0bee50a5a0af4421b3b403a44ef24895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Glioma
    119 rdf:type schema:DefinedTerm
    120 N1ea2cecf0f9043339e93977e56f8e861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Isocitrate Dehydrogenase
    122 rdf:type schema:DefinedTerm
    123 N1ec86f225307409298b78de7276bbba1 rdf:first sg:person.0615710140.60
    124 rdf:rest Na52247fe32ee4436b61a65753b2ae270
    125 N20b6a7278f4e4d68ba3a880c889a76b1 rdf:first sg:person.015733176664.90
    126 rdf:rest Ne447ef006480478495fe8b3168550d68
    127 N2c874eaed25f479381d07e2297786398 schema:volumeNumber 159
    128 rdf:type schema:PublicationVolume
    129 N5059f0d700a54d828383795623123c41 rdf:first sg:person.014317055643.84
    130 rdf:rest N20b6a7278f4e4d68ba3a880c889a76b1
    131 N606bb2fbc47a4e7c91d8ba6daad68065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Kaplan-Meier Estimate
    133 rdf:type schema:DefinedTerm
    134 N664a074f62ff4b8e829eb922bf2f112b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 N6b69778ea2c94723bd805fe8278705b1 rdf:first sg:person.01234057223.77
    138 rdf:rest Nb77a88d2bf48463bb2c777c959136948
    139 N7a26cb50aab44e9b946c138cf2829205 schema:name pubmed_id
    140 schema:value 35779193
    141 rdf:type schema:PropertyValue
    142 N82eac67882df4dea8db4ccc1ff9e6cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Glioblastoma
    144 rdf:type schema:DefinedTerm
    145 Na52247fe32ee4436b61a65753b2ae270 rdf:first sg:person.01372162736.43
    146 rdf:rest N6b69778ea2c94723bd805fe8278705b1
    147 Na7a23e2195044ac0a9366514abb850de schema:name dimensions_id
    148 schema:value pub.1149182764
    149 rdf:type schema:PropertyValue
    150 Nabab91e3261348a6b0e37b5cce03055a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Brain Neoplasms
    152 rdf:type schema:DefinedTerm
    153 Nb37929db0fab4ea1b1688e94b6a46a44 schema:issueNumber 2
    154 rdf:type schema:PublicationIssue
    155 Nb77a88d2bf48463bb2c777c959136948 rdf:first sg:person.01307650417.11
    156 rdf:rest rdf:nil
    157 Nbb67a924b3624b9ebbbb00b39cd2d3d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Prognosis
    159 rdf:type schema:DefinedTerm
    160 Nc41fd80529034a68b18e18e48a5e38c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Mutation
    162 rdf:type schema:DefinedTerm
    163 Nd909ec6560f143f1929da04423246ca0 schema:name doi
    164 schema:value 10.1007/s11060-022-04074-9
    165 rdf:type schema:PropertyValue
    166 Ne036a52930b144e8a09c30ef1805b31e schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 Ne447ef006480478495fe8b3168550d68 rdf:first sg:person.0757104023.49
    169 rdf:rest N1ec86f225307409298b78de7276bbba1
    170 Nefde3a20cf344defac3219c247d54b98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Phosphatidylinositol 3-Kinases
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Medical and Health Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Oncology and Carcinogenesis
    178 rdf:type schema:DefinedTerm
    179 sg:grant.8420184 http://pending.schema.org/fundedItem sg:pub.10.1007/s11060-022-04074-9
    180 rdf:type schema:MonetaryGrant
    181 sg:journal.1094205 schema:issn 0167-594X
    182 1573-7373
    183 schema:name Journal of Neuro-Oncology
    184 schema:publisher Springer Nature
    185 rdf:type schema:Periodical
    186 sg:person.01234057223.77 schema:affiliation grid-institutes:grid.411403.3
    187 schema:familyName Nanjo
    188 schema:givenName Hiroshi
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234057223.77
    190 rdf:type schema:Person
    191 sg:person.01307650417.11 schema:affiliation grid-institutes:grid.251924.9
    192 schema:familyName Shimizu
    193 schema:givenName Hiroaki
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307650417.11
    195 rdf:type schema:Person
    196 sg:person.01372162736.43 schema:affiliation grid-institutes:grid.411790.a
    197 schema:familyName Sugai
    198 schema:givenName Tamotsu
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372162736.43
    200 rdf:type schema:Person
    201 sg:person.014317055643.84 schema:affiliation grid-institutes:grid.251924.9
    202 schema:familyName Suzuki
    203 schema:givenName Hayato
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317055643.84
    205 rdf:type schema:Person
    206 sg:person.015733176664.90 schema:affiliation grid-institutes:grid.251924.9
    207 schema:familyName Ono
    208 schema:givenName Takahiro
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015733176664.90
    210 rdf:type schema:Person
    211 sg:person.0615710140.60 schema:affiliation grid-institutes:grid.251924.9
    212 schema:familyName Takahashi
    213 schema:givenName Masataka
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615710140.60
    215 rdf:type schema:Person
    216 sg:person.0757104023.49 schema:affiliation grid-institutes:grid.251924.9
    217 schema:familyName Koyota
    218 schema:givenName Souichi
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757104023.49
    220 rdf:type schema:Person
    221 sg:pub.10.1007/bf00496983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029931732
    222 https://doi.org/10.1007/bf00496983
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00401-015-1519-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014983828
    225 https://doi.org/10.1007/s00401-015-1519-8
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00401-017-1710-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084768901
    228 https://doi.org/10.1007/s00401-017-1710-1
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00401-018-1849-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103604946
    231 https://doi.org/10.1007/s00401-018-1849-4
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00401-018-1905-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106679483
    234 https://doi.org/10.1007/s00401-018-1905-0
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1007/s00401-019-02078-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1121371100
    237 https://doi.org/10.1007/s00401-019-02078-w
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/s10014-014-0186-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000403235
    240 https://doi.org/10.1007/s10014-014-0186-0
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1007/s11060-017-2433-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085430606
    243 https://doi.org/10.1007/s11060-017-2433-9
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    246 https://doi.org/10.1038/bmt.2012.244
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nature26000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101533700
    249 https://doi.org/10.1038/nature26000
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/ng.3273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007363870
    252 https://doi.org/10.1038/ng.3273
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nm.4333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085214027
    255 https://doi.org/10.1038/nm.4333
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/s41591-018-0337-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112059795
    258 https://doi.org/10.1038/s41591-018-0337-7
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1186/s13073-017-0424-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084826380
    261 https://doi.org/10.1186/s13073-017-0424-2
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1186/s13073-021-00979-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141826099
    264 https://doi.org/10.1186/s13073-021-00979-8
    265 rdf:type schema:CreativeWork
    266 grid-institutes:grid.251924.9 schema:alternateName Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan
    267 Molecular Medicine Laboratory, Bioscience Education and Research Support Center, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan
    268 schema:name Department of Neurosurgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan
    269 Molecular Medicine Laboratory, Bioscience Education and Research Support Center, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Akita, Japan
    270 rdf:type schema:Organization
    271 grid-institutes:grid.411403.3 schema:alternateName Department of Surgical Pathology, Akita University Hospital, 44-2 Hasunuma Hiroomote, 010-8543, Akita, Akita, Japan
    272 schema:name Department of Surgical Pathology, Akita University Hospital, 44-2 Hasunuma Hiroomote, 010-8543, Akita, Akita, Japan
    273 rdf:type schema:Organization
    274 grid-institutes:grid.411790.a schema:alternateName Department of Pathology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, 028-3694, Iwate, Japan
    275 schema:name Department of Pathology, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, 028-3694, Iwate, Japan
    276 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...