Health related quality of life trajectories after stereotactic radiosurgery for brain metastases: a systematic review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-04

AUTHORS

Adomas Bunevicius, Laura Donovan, Jason Sheehan

ABSTRACT

PurposeHealth related quality of life (HRQoL) is often used as an outcome measure of cancer treatment. Stereotactic radiosurgery (SRS) is a mainstay treatment of brain metastases (BMs) with constantly improving treatment envelope. The goal of this systematic review was to evaluated HRQoL trajectories after SRS, identify important predictors of HRQoL after SRS, and to evaluate clinical importance of post-SRS HRQoL trajectories of BM patients treated with SRS.MethodsA systematic literature review according to the PRISMA guidelines analyzing HRQoL trajectories after SRS for BM published in the Pubmed/MEDLINE database before January, 2022.ResultsWe identified 18 studies that evaluated HRQoL before and at least once after SRS for BMs. The majority of studies were single-institution retrospective series and included patients with different cancer types. Different instruments were used to assess HRQoL. In the majority of studies (n = 10) at group level, there was no significant change in global HRQoL after SRS. Stability, improvement, and deterioration of HRQoL global and subscale scores at individual patient level were common. Post-SRS HRQoL deterioration was predicted by worse functional status, greater number of BMs, delayed SRS, symptomatic BMs, and presence of seizures and cognitive impairment. Shorter post-SRS survival and adverse radiation effects (AREs) were associated with worse HRQoL.ConclusionsSRS for BMs is often associated with sustained preservation of HRQoL. Individual variation of HRQoL domains after SRS is common. Shorter survival and AREs are associated with worse HRQoL. Worse functional status and greater disease burden predict unfavorable HRQoL trajectories after SRS for BMs. More... »

PAGES

319-331

References to SciGraph publications

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  • 2018-08-04. Neurocognitive evaluation of brain metastases patients treated with post-resection stereotactic radiosurgery: a prospective single arm clinical trial in JOURNAL OF NEURO-ONCOLOGY
  • 2019-08-15. Quality of life in patients with limited (1–3) brain metastases undergoing stereotactic or whole brain radiotherapy in STRAHLENTHERAPIE UND ONKOLOGIE
  • 2000-08. Long-term survival with metastatic cancer to the brain in MEDICAL ONCOLOGY
  • 2019-12-02. Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review in SUPPORTIVE CARE IN CANCER
  • 2019-01-17. Brain metastases in NATURE REVIEWS DISEASE PRIMERS
  • 2018-04-16. Individual changes in neurocognitive functioning and health-related quality of life in patients with brain oligometastases treated with stereotactic radiotherapy in JOURNAL OF NEURO-ONCOLOGY
  • 2011-10-20. Epidemiology of Brain Metastases in CURRENT ONCOLOGY REPORTS
  • 2020-10-06. Health-related quality of life after Gamma Knife radiosurgery in patients with 1–10 brain metastases in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2013-11-28. Psychometric validation of the functional assessment of cancer therapy—brain (FACT-Br) for assessing quality of life in patients with brain metastases in SUPPORTIVE CARE IN CANCER
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    http://scigraph.springernature.com/pub.10.1007/s11060-022-04067-8

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    http://dx.doi.org/10.1007/s11060-022-04067-8

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35788469


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