Presentation, imaging, patterns of care, growth, and outcome in sporadic and von Hippel–Lindau-associated central nervous system hemangioblastomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-28

AUTHORS

Hirokazu Takami, Christopher S. Graffeo, Avital Perry, Desmond A. Brown, Fredric B. Meyer, Terry C. Burns, Ian F. Parney

ABSTRACT

ObjectHemangioblastoma is a relatively rare neoplasm occurring mostly in the cerebellum that may arise sporadically or in the context of von Hippel–Lindau (VHL) syndrome. Presentation, imaging, natural history, surgical patterns of care, and outcomes are incompletely defined for this uncommon lesion. We reviewed our large institutional series to help clarify these issues.MethodsRetrospective analysis of consecutive, neurosurgically managed CNS hemangioblastomas at Mayo Clinic, 1988–2018.ResultsTwo hundred and eighty five hemangioblastomas were treated in 184 unique patients (115 sporadic, 69 VHL). Compared to sporadic patients, VHL patients were younger (36.7 vs 51.7 years; p < 0.0001), were treated while asymptomatic more commonly (47.3 vs 4.2%; p < 0.0001), had smaller lesions (6.6 vs 13.9 mL; p < 0.0001), and harbored lesions with associated cysts less frequently (51.0 vs 75.0%; p = 0.0002). Macrocystic tumor architecture was associated with larger lesion size and greater symptom severity. Solid lesions later formed cysts at a median 130 months. Growth in both total volume and solid component accelerated after cyst formation (10.6 and 6.0 times median rate prior to cyst emergence). VHL patients died at a younger age (47.9 vs 74.5, p = 0.0017) and were more likely to die of direct disease sequelae. Though treatment-free survival time was significantly longer in sporadic cases, a substantial fraction (> 40%) developed tumor recurrence/progression requiring additional treatment.ConclusionsHemangioblastoma presentation varies with etiology and clinical course is more complicated in VHL cases. Nodular lesions often develop cysts over time which is associated with accelerated tumor growth. Sporadic cases have a previously unappreciated but substantial risk of late recurrence/progression requiring treatment. More... »

PAGES

221-231

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-022-04021-8

DOI

http://dx.doi.org/10.1007/s11060-022-04021-8

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https://app.dimensions.ai/details/publication/pub.1149821679

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35902552


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