Ontology type: schema:ScholarlyArticle Open Access: True
2021-02-23
AUTHORSAnne-Sophie Montero, Suzanne Tran, Aymeric Amelot, Félix Berriat, Guillaume Lot, Stephan Gaillard, Chiara Villa, Marc Polivka, Clovis Adam, Ahmed Idbaih, Loïc Feuvret, Alexandre Carpentier, Fabrice Parker, Franck Bielle, Bertrand Mathon
ABSTRACTPurposeMyxopapillary ependymoma (MPE) is the most frequent tumor affecting the medullary conus. The surgical therapeutic management is still debated and only few studies have focused on the postoperative clinical outcome of patients. This study aimed to demonstrate long-term postoperative outcome and to assess the predictive factors of recurrence as well as the clinical evolution of these patients.MethodsFrom 1984 to 2019, in four French centers, 101 adult patients diagnosed with MPE were retrospectively included.ResultsMedian age at surgery was 39 years. Median tumor size was 50 mm and lesions were multifocal in 13% of patients. All patients benefited from surgery and one patient received postoperative radiotherapy. Gross total resection was obtained in 75% of cases. Sixteen percent of patients presented recurrence after a median follow-up of 70 months. Progression free survival at 5 and 10 years were respectively estimated at 83% and 79%. After multivariable analysis, sacral localization, and subtotal resection were shown to be independently associated with tumor recurrence. 85% of the patients had a favorable evolution concerning pain. 12% of the patients presented a postoperative deterioration of sphincter function and 4% of motor function.ConclusionSurgery alone is an acceptable option for MPE patients. Patients with sacral location or incomplete resection are at high risk of recurrence and should be carefully monitored. More... »
PAGES491-499
http://scigraph.springernature.com/pub.10.1007/s11060-021-03717-7
DOIhttp://dx.doi.org/10.1007/s11060-021-03717-7
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33624261
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