Clinical characteristics and long-term surgical outcome of spinal myxopapillary ependymoma: a French cohort of 101 patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-02-23

AUTHORS

Anne-Sophie Montero, Suzanne Tran, Aymeric Amelot, Félix Berriat, Guillaume Lot, Stephan Gaillard, Chiara Villa, Marc Polivka, Clovis Adam, Ahmed Idbaih, Loïc Feuvret, Alexandre Carpentier, Fabrice Parker, Franck Bielle, Bertrand Mathon

ABSTRACT

PurposeMyxopapillary ependymoma (MPE) is the most frequent tumor affecting the medullary conus. The surgical therapeutic management is still debated and only few studies have focused on the postoperative clinical outcome of patients. This study aimed to demonstrate long-term postoperative outcome and to assess the predictive factors of recurrence as well as the clinical evolution of these patients.MethodsFrom 1984 to 2019, in four French centers, 101 adult patients diagnosed with MPE were retrospectively included.ResultsMedian age at surgery was 39 years. Median tumor size was 50 mm and lesions were multifocal in 13% of patients. All patients benefited from surgery and one patient received postoperative radiotherapy. Gross total resection was obtained in 75% of cases. Sixteen percent of patients presented recurrence after a median follow-up of 70 months. Progression free survival at 5 and 10 years were respectively estimated at 83% and 79%. After multivariable analysis, sacral localization, and subtotal resection were shown to be independently associated with tumor recurrence. 85% of the patients had a favorable evolution concerning pain. 12% of the patients presented a postoperative deterioration of sphincter function and 4% of motor function.ConclusionSurgery alone is an acceptable option for MPE patients. Patients with sacral location or incomplete resection are at high risk of recurrence and should be carefully monitored. More... »

PAGES

491-499

Journal

TITLE

Journal of Neuro-Oncology

ISSUE

3

VOLUME

152

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-021-03717-7

DOI

http://dx.doi.org/10.1007/s11060-021-03717-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1135657981

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33624261


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16 schema:description PurposeMyxopapillary ependymoma (MPE) is the most frequent tumor affecting the medullary conus. The surgical therapeutic management is still debated and only few studies have focused on the postoperative clinical outcome of patients. This study aimed to demonstrate long-term postoperative outcome and to assess the predictive factors of recurrence as well as the clinical evolution of these patients.MethodsFrom 1984 to 2019, in four French centers, 101 adult patients diagnosed with MPE were retrospectively included.ResultsMedian age at surgery was 39 years. Median tumor size was 50 mm and lesions were multifocal in 13% of patients. All patients benefited from surgery and one patient received postoperative radiotherapy. Gross total resection was obtained in 75% of cases. Sixteen percent of patients presented recurrence after a median follow-up of 70 months. Progression free survival at 5 and 10 years were respectively estimated at 83% and 79%. After multivariable analysis, sacral localization, and subtotal resection were shown to be independently associated with tumor recurrence. 85% of the patients had a favorable evolution concerning pain. 12% of the patients presented a postoperative deterioration of sphincter function and 4% of motor function.ConclusionSurgery alone is an acceptable option for MPE patients. Patients with sacral location or incomplete resection are at high risk of recurrence and should be carefully monitored.
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22 schema:keywords ConclusionSurgery
23 French centers
24 French cohort
25 MPE
26 MPE patients
27 MethodsFrom 1984
28 ResultsMedian age
29 acceptable option
30 adult patients
31 age
32 analysis
33 cases
34 center
35 characteristics
36 clinical characteristics
37 clinical evolution
38 clinical outcomes
39 cohort
40 conus
41 deterioration
42 ependymoma
43 evolution
44 factors
45 favorable evolution
46 free survival
47 frequent tumors
48 function
49 gross total resection
50 high risk
51 incomplete resection
52 lesions
53 localization
54 location
55 long-term postoperative outcomes
56 long-term surgical outcomes
57 management
58 median tumor size
59 medullary conus
60 months
61 motor function
62 multivariable analysis
63 myxopapillary ependymoma
64 options
65 outcomes
66 pain
67 patients
68 percent
69 percent of patients
70 postoperative clinical outcomes
71 postoperative deterioration
72 postoperative outcomes
73 postoperative radiotherapy
74 predictive factors
75 radiotherapy
76 recurrence
77 resection
78 risk
79 sacral localization
80 sacral location
81 size
82 sphincter function
83 spinal myxopapillary ependymoma
84 study
85 subtotal resection
86 surgery
87 surgical outcomes
88 survival
89 therapeutic management
90 total resection
91 tumor recurrence
92 tumor size
93 tumors
94 years
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