Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors View Full Text


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Article Info

DATE

2020-02-28

AUTHORS

Kevin Beccaria, Aria Sabbagh, John de Groot, Michael Canney, Alexandre Carpentier, Amy B. Heimberger

ABSTRACT

IntroductionOpening of the blood–brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now recognized as a safe technique to transiently and repeatedly open the BBB. This non- or minimally invasive technique allows for a targeted and uniform dispersal of a wide range of therapeutic substances throughout the brain, including immune cells and antibodies.MethodsIn this review article, we summarize pre-clinical studies that have used BBB-opening by pulsed low intensity ultrasound to enhance the delivery of immune therapeutics and effector cell populations, as well as several recent clinical studies that have been initiated. Based on this analysis, we propose immune therapeutic strategies that are most likely to benefit from this strategy. The literature review and trial data research were performed using Medline/Pubmed databases and clinical trial registry www.clinicaltrials.gov. The reference lists of all included articles were searched for additional studies.ResultsA wide range of immune therapeutic agents, including small molecular weight drugs, antibodies or NK cells, have been safely and efficiently delivered to the brain with pulsed low intensity ultrasound in preclinical models, and both tumor control and increased survival have been demonstrated in different types of brain tumor models in rodents. Ultrasound-induced BBB disruption may also stimulate innate and cellular immune responses.ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment. More... »

PAGES

65-73

References to SciGraph publications

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  • 2011-05-25. Engineered antibodies cross blood–brain barrier in NATURE
  • 2015-12-08. Enhanced brain distribution of carboplatin in a primate model after blood–brain barrier disruption using an implantable ultrasound device in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2018-08-13. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors in NATURE MEDICINE
  • 2019-01-23. Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study in SCIENTIFIC REPORTS
  • 2016-08-24. Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2019-06-13. Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma in JOURNAL OF NEURO-ONCOLOGY
  • 2017-06-08. Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I disease in ORPHANET JOURNAL OF RARE DISEASES
  • 2019-06-25. Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody in SCIENTIFIC REPORTS
  • 2015-06-01. Structural and functional features of central nervous system lymphatic vessels in NATURE
  • 2018-04-26. Focused Ultrasound-enabled Brain Tumor Liquid Biopsy in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8

    DOI

    http://dx.doi.org/10.1007/s11060-020-03425-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125140781

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32112296


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