Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-02-28

AUTHORS

Kevin Beccaria, Aria Sabbagh, John de Groot, Michael Canney, Alexandre Carpentier, Amy B. Heimberger

ABSTRACT

IntroductionOpening of the blood–brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now recognized as a safe technique to transiently and repeatedly open the BBB. This non- or minimally invasive technique allows for a targeted and uniform dispersal of a wide range of therapeutic substances throughout the brain, including immune cells and antibodies.MethodsIn this review article, we summarize pre-clinical studies that have used BBB-opening by pulsed low intensity ultrasound to enhance the delivery of immune therapeutics and effector cell populations, as well as several recent clinical studies that have been initiated. Based on this analysis, we propose immune therapeutic strategies that are most likely to benefit from this strategy. The literature review and trial data research were performed using Medline/Pubmed databases and clinical trial registry www.clinicaltrials.gov. The reference lists of all included articles were searched for additional studies.ResultsA wide range of immune therapeutic agents, including small molecular weight drugs, antibodies or NK cells, have been safely and efficiently delivered to the brain with pulsed low intensity ultrasound in preclinical models, and both tumor control and increased survival have been demonstrated in different types of brain tumor models in rodents. Ultrasound-induced BBB disruption may also stimulate innate and cellular immune responses.ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment. More... »

PAGES

65-73

References to SciGraph publications

  • 2015-03-17. Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2003-07. Three or more routes for leukocyte migration into the central nervous system in NATURE REVIEWS IMMUNOLOGY
  • 2011-05-25. Engineered antibodies cross blood–brain barrier in NATURE
  • 2015-12-08. Enhanced brain distribution of carboplatin in a primate model after blood–brain barrier disruption using an implantable ultrasound device in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2018-08-13. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors in NATURE MEDICINE
  • 2019-01-23. Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study in SCIENTIFIC REPORTS
  • 2016-08-24. Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2019-06-13. Temporary blood–brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma in JOURNAL OF NEURO-ONCOLOGY
  • 2017-06-08. Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I disease in ORPHANET JOURNAL OF RARE DISEASES
  • 2019-06-25. Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody in SCIENTIFIC REPORTS
  • 2015-06-01. Structural and functional features of central nervous system lymphatic vessels in NATURE
  • 2018-04-26. Focused Ultrasound-enabled Brain Tumor Liquid Biopsy in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8

    DOI

    http://dx.doi.org/10.1007/s11060-020-03425-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1125140781

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32112296


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood-Brain Barrier", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Central Nervous System Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ultrasonic Waves", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ultrasonography", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beccaria", 
            "givenName": "Kevin", 
            "id": "sg:person.0657412052.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657412052.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sabbagh", 
            "givenName": "Aria", 
            "id": "sg:person.014107441637.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014107441637.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Groot", 
            "givenName": "John", 
            "id": "sg:person.0662322764.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322764.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CarThera, Institut du Cerveau Et de La Moelle \u00e9pini\u00e8re (ICM), 75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.425274.2", 
              "name": [
                "CarThera, Institut du Cerveau Et de La Moelle \u00e9pini\u00e8re (ICM), 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Canney", 
            "givenName": "Michael", 
            "id": "sg:person.01003501733.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003501733.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, Sorbonne Universit\u00e9, UPMC Univ Paris 06, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires La Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Department of Neurosurgery, Sorbonne Universit\u00e9, UPMC Univ Paris 06, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires La Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carpentier", 
            "givenName": "Alexandre", 
            "id": "sg:person.011366010012.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011366010012.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Unit 422, P.O. Box 301402, 77230-1402, Houston, TX, USA", 
              "id": "http://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA", 
                "Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Unit 422, P.O. Box 301402, 77230-1402, Houston, TX, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heimberger", 
            "givenName": "Amy B.", 
            "id": "sg:person.0745122131.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745122131.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature14432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736772", 
              "https://doi.org/10.1038/nature14432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41591-018-0135-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105917926", 
              "https://doi.org/10.1038/s41591-018-0135-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-019-03204-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117128117", 
              "https://doi.org/10.1007/s11060-019-03204-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12957-016-0975-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030376821", 
              "https://doi.org/10.1186/s12957-016-0975-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-24516-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103565862", 
              "https://doi.org/10.1038/s41598-018-24516-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-36340-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111618527", 
              "https://doi.org/10.1038/s41598-018-36340-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12967-015-0451-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035172536", 
              "https://doi.org/10.1186/s12967-015-0451-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019686035", 
              "https://doi.org/10.1038/nri1130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-015-2930-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044219132", 
              "https://doi.org/10.1007/s00280-015-2930-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13023-017-0649-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085932040", 
              "https://doi.org/10.1186/s13023-017-0649-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-45577-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1117491792", 
              "https://doi.org/10.1038/s41598-019-45577-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/news.2011.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056456268", 
              "https://doi.org/10.1038/news.2011.319"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-02-28", 
        "datePublishedReg": "2020-02-28", 
        "description": "IntroductionOpening of the blood\u2013brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now recognized as a safe technique to transiently and repeatedly open the BBB. This non- or minimally invasive technique allows for a targeted and uniform dispersal of a wide range of therapeutic substances throughout the brain, including immune cells and antibodies.MethodsIn this review article, we summarize pre-clinical studies that have used BBB-opening by pulsed low intensity ultrasound to enhance the delivery of immune therapeutics and effector cell populations, as well as several recent clinical studies that have been initiated. Based on this analysis, we propose immune therapeutic strategies that are most likely to benefit from this strategy. The literature review and trial data research were performed using Medline/Pubmed databases and clinical trial registry www.clinicaltrials.gov. The reference lists of all included articles were searched for additional studies.ResultsA wide range of immune therapeutic agents, including small molecular weight drugs, antibodies or NK cells, have been safely and efficiently delivered to the brain with pulsed low intensity ultrasound in preclinical models, and both tumor control and increased survival have been demonstrated in different types of brain tumor models in rodents. Ultrasound-induced BBB disruption may also stimulate innate and cellular immune responses.ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11060-020-03425-8", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1094205", 
            "issn": [
              "0167-594X", 
              "1573-7373"
            ], 
            "name": "Journal of Neuro-Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "151"
          }
        ], 
        "keywords": [
          "blood-brain barrier", 
          "immune therapeutics", 
          "low-intensity ultrasound", 
          "immune therapeutic strategies", 
          "blood-brain barrier opening", 
          "effector cell populations", 
          "cellular immune responses", 
          "recent clinical studies", 
          "immune therapeutic agents", 
          "pre-clinical studies", 
          "brain tumor model", 
          "brain tumor treatment", 
          "BBB disruption", 
          "NK cells", 
          "CNS tumors", 
          "tumor control", 
          "BBB opening", 
          "immune modulation", 
          "immune cells", 
          "clinical trials", 
          "preclinical models", 
          "clinical studies", 
          "safe technique", 
          "immune response", 
          "MEDLINE/", 
          "invasive techniques", 
          "therapeutic strategies", 
          "reference lists", 
          "barrier opening", 
          "tumor model", 
          "therapeutic agents", 
          "Additional studies", 
          "therapeutic substances", 
          "cell populations", 
          "ultrasound", 
          "tumor treatment", 
          "small molecular weight drugs", 
          "brain", 
          "antibodies", 
          "review article", 
          "therapeutics", 
          "weight drugs", 
          "therapeutic delivery", 
          "literature review", 
          "delivery", 
          "encouraging results", 
          "cells", 
          "intensity ultrasound", 
          "tumors", 
          "MethodsIn", 
          "trials", 
          "study", 
          "drugs", 
          "survival", 
          "treatment", 
          "rodents", 
          "low intensity", 
          "association", 
          "review", 
          "population", 
          "agents", 
          "strategies", 
          "last decade", 
          "disruption", 
          "response", 
          "modulation", 
          "database", 
          "control", 
          "substances", 
          "www", 
          "different types", 
          "opening", 
          "barriers", 
          "wide range", 
          "list", 
          "types", 
          "technique", 
          "article", 
          "decades", 
          "analysis", 
          "model", 
          "results", 
          "new field", 
          "intensity", 
          "range", 
          "research", 
          "data research", 
          "field", 
          "uniform dispersal", 
          "dispersal"
        ], 
        "name": "Blood\u2013brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors", 
        "pagination": "65-73", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1125140781"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11060-020-03425-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "32112296"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11060-020-03425-8", 
          "https://app.dimensions.ai/details/publication/pub.1125140781"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_876.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11060-020-03425-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-020-03425-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    272 TRIPLES      21 PREDICATES      133 URIs      113 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11060-020-03425-8 schema:about N0005c6fb42554f63a5e9a6b3fb427331
    2 N321d842697b3472b89fd37a008e6477d
    3 N882209c174f64120b6d0677740d6fbb1
    4 N93a38df9428143d79c586de29bbf61a7
    5 Nac54dc943a7b4d858eb69eaf7b48e28c
    6 Nb97cc05997ab488d9d244ccbef45b666
    7 Ne689c3b7cf2c44fc8bc55e3ab70fc9d8
    8 anzsrc-for:11
    9 anzsrc-for:1107
    10 schema:author Na8b3bbd4ea4243fab044a32bf565e6e1
    11 schema:citation sg:pub.10.1007/s00280-015-2930-5
    12 sg:pub.10.1007/s11060-019-03204-0
    13 sg:pub.10.1038/nature14432
    14 sg:pub.10.1038/news.2011.319
    15 sg:pub.10.1038/nri1130
    16 sg:pub.10.1038/s41591-018-0135-2
    17 sg:pub.10.1038/s41598-018-24516-7
    18 sg:pub.10.1038/s41598-018-36340-0
    19 sg:pub.10.1038/s41598-019-45577-2
    20 sg:pub.10.1186/s12957-016-0975-5
    21 sg:pub.10.1186/s12967-015-0451-y
    22 sg:pub.10.1186/s13023-017-0649-6
    23 schema:datePublished 2020-02-28
    24 schema:datePublishedReg 2020-02-28
    25 schema:description IntroductionOpening of the blood–brain barrier (BBB) by pulsed low intensity ultrasound has been developed during the last decade and is now recognized as a safe technique to transiently and repeatedly open the BBB. This non- or minimally invasive technique allows for a targeted and uniform dispersal of a wide range of therapeutic substances throughout the brain, including immune cells and antibodies.MethodsIn this review article, we summarize pre-clinical studies that have used BBB-opening by pulsed low intensity ultrasound to enhance the delivery of immune therapeutics and effector cell populations, as well as several recent clinical studies that have been initiated. Based on this analysis, we propose immune therapeutic strategies that are most likely to benefit from this strategy. The literature review and trial data research were performed using Medline/Pubmed databases and clinical trial registry www.clinicaltrials.gov. The reference lists of all included articles were searched for additional studies.ResultsA wide range of immune therapeutic agents, including small molecular weight drugs, antibodies or NK cells, have been safely and efficiently delivered to the brain with pulsed low intensity ultrasound in preclinical models, and both tumor control and increased survival have been demonstrated in different types of brain tumor models in rodents. Ultrasound-induced BBB disruption may also stimulate innate and cellular immune responses.ConclusionsUltrasound BBB opening has just recently entered clinical trials with encouraging results, and the association of this strategy with immune therapeutics creates a new field of brain tumor treatment.
    26 schema:genre article
    27 schema:isAccessibleForFree false
    28 schema:isPartOf N03795df81665465fb9a6bcfc536f573a
    29 N5f55cf8fb2b54be6b3b2a82e1065e937
    30 sg:journal.1094205
    31 schema:keywords Additional studies
    32 BBB disruption
    33 BBB opening
    34 CNS tumors
    35 MEDLINE/
    36 MethodsIn
    37 NK cells
    38 agents
    39 analysis
    40 antibodies
    41 article
    42 association
    43 barrier opening
    44 barriers
    45 blood-brain barrier
    46 blood-brain barrier opening
    47 brain
    48 brain tumor model
    49 brain tumor treatment
    50 cell populations
    51 cells
    52 cellular immune responses
    53 clinical studies
    54 clinical trials
    55 control
    56 data research
    57 database
    58 decades
    59 delivery
    60 different types
    61 dispersal
    62 disruption
    63 drugs
    64 effector cell populations
    65 encouraging results
    66 field
    67 immune cells
    68 immune modulation
    69 immune response
    70 immune therapeutic agents
    71 immune therapeutic strategies
    72 immune therapeutics
    73 intensity
    74 intensity ultrasound
    75 invasive techniques
    76 last decade
    77 list
    78 literature review
    79 low intensity
    80 low-intensity ultrasound
    81 model
    82 modulation
    83 new field
    84 opening
    85 population
    86 pre-clinical studies
    87 preclinical models
    88 range
    89 recent clinical studies
    90 reference lists
    91 research
    92 response
    93 results
    94 review
    95 review article
    96 rodents
    97 safe technique
    98 small molecular weight drugs
    99 strategies
    100 study
    101 substances
    102 survival
    103 technique
    104 therapeutic agents
    105 therapeutic delivery
    106 therapeutic strategies
    107 therapeutic substances
    108 therapeutics
    109 treatment
    110 trials
    111 tumor control
    112 tumor model
    113 tumor treatment
    114 tumors
    115 types
    116 ultrasound
    117 uniform dispersal
    118 weight drugs
    119 wide range
    120 www
    121 schema:name Blood–brain barrier opening with low intensity pulsed ultrasound for immune modulation and immune therapeutic delivery to CNS tumors
    122 schema:pagination 65-73
    123 schema:productId N094f475cdd8d46499de4c7402cdf3ba1
    124 N2a4aa0161b864f21babff43f72879496
    125 N4709c08af2da45a4b0012b8782e4de4b
    126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125140781
    127 https://doi.org/10.1007/s11060-020-03425-8
    128 schema:sdDatePublished 2022-09-02T16:05
    129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    130 schema:sdPublisher Na9868cf9831f4a3b939102ae2d5d43b8
    131 schema:url https://doi.org/10.1007/s11060-020-03425-8
    132 sgo:license sg:explorer/license/
    133 sgo:sdDataset articles
    134 rdf:type schema:ScholarlyArticle
    135 N0005c6fb42554f63a5e9a6b3fb427331 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Brain Neoplasms
    137 rdf:type schema:DefinedTerm
    138 N03795df81665465fb9a6bcfc536f573a schema:issueNumber 1
    139 rdf:type schema:PublicationIssue
    140 N094f475cdd8d46499de4c7402cdf3ba1 schema:name dimensions_id
    141 schema:value pub.1125140781
    142 rdf:type schema:PropertyValue
    143 N2a4aa0161b864f21babff43f72879496 schema:name pubmed_id
    144 schema:value 32112296
    145 rdf:type schema:PropertyValue
    146 N321d842697b3472b89fd37a008e6477d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Humans
    148 rdf:type schema:DefinedTerm
    149 N4709c08af2da45a4b0012b8782e4de4b schema:name doi
    150 schema:value 10.1007/s11060-020-03425-8
    151 rdf:type schema:PropertyValue
    152 N579eb3e0730d4a6dad80bdb5b3582e5d rdf:first sg:person.01003501733.49
    153 rdf:rest Na1020607c36d4fe4b7566f61c16a4212
    154 N5f55cf8fb2b54be6b3b2a82e1065e937 schema:volumeNumber 151
    155 rdf:type schema:PublicationVolume
    156 N825297812dae4c42ac8f8bedb6651ab7 rdf:first sg:person.0662322764.76
    157 rdf:rest N579eb3e0730d4a6dad80bdb5b3582e5d
    158 N882209c174f64120b6d0677740d6fbb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Ultrasonography
    160 rdf:type schema:DefinedTerm
    161 N8bfea54d233f4a9299c797389bf36ec2 rdf:first sg:person.014107441637.40
    162 rdf:rest N825297812dae4c42ac8f8bedb6651ab7
    163 N93a38df9428143d79c586de29bbf61a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Brain
    165 rdf:type schema:DefinedTerm
    166 Na1020607c36d4fe4b7566f61c16a4212 rdf:first sg:person.011366010012.56
    167 rdf:rest Nb9d067b80356426bbb513f69e387f96b
    168 Na8b3bbd4ea4243fab044a32bf565e6e1 rdf:first sg:person.0657412052.49
    169 rdf:rest N8bfea54d233f4a9299c797389bf36ec2
    170 Na9868cf9831f4a3b939102ae2d5d43b8 schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 Nac54dc943a7b4d858eb69eaf7b48e28c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Blood-Brain Barrier
    174 rdf:type schema:DefinedTerm
    175 Nb97cc05997ab488d9d244ccbef45b666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Central Nervous System Neoplasms
    177 rdf:type schema:DefinedTerm
    178 Nb9d067b80356426bbb513f69e387f96b rdf:first sg:person.0745122131.07
    179 rdf:rest rdf:nil
    180 Ne689c3b7cf2c44fc8bc55e3ab70fc9d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Ultrasonic Waves
    182 rdf:type schema:DefinedTerm
    183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Medical and Health Sciences
    185 rdf:type schema:DefinedTerm
    186 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Immunology
    188 rdf:type schema:DefinedTerm
    189 sg:journal.1094205 schema:issn 0167-594X
    190 1573-7373
    191 schema:name Journal of Neuro-Oncology
    192 schema:publisher Springer Nature
    193 rdf:type schema:Periodical
    194 sg:person.01003501733.49 schema:affiliation grid-institutes:grid.425274.2
    195 schema:familyName Canney
    196 schema:givenName Michael
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003501733.49
    198 rdf:type schema:Person
    199 sg:person.011366010012.56 schema:affiliation grid-institutes:grid.462844.8
    200 schema:familyName Carpentier
    201 schema:givenName Alexandre
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011366010012.56
    203 rdf:type schema:Person
    204 sg:person.014107441637.40 schema:affiliation grid-institutes:grid.240145.6
    205 schema:familyName Sabbagh
    206 schema:givenName Aria
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014107441637.40
    208 rdf:type schema:Person
    209 sg:person.0657412052.49 schema:affiliation grid-institutes:grid.240145.6
    210 schema:familyName Beccaria
    211 schema:givenName Kevin
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657412052.49
    213 rdf:type schema:Person
    214 sg:person.0662322764.76 schema:affiliation grid-institutes:grid.240145.6
    215 schema:familyName de Groot
    216 schema:givenName John
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322764.76
    218 rdf:type schema:Person
    219 sg:person.0745122131.07 schema:affiliation grid-institutes:grid.240145.6
    220 schema:familyName Heimberger
    221 schema:givenName Amy B.
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745122131.07
    223 rdf:type schema:Person
    224 sg:pub.10.1007/s00280-015-2930-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044219132
    225 https://doi.org/10.1007/s00280-015-2930-5
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s11060-019-03204-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117128117
    228 https://doi.org/10.1007/s11060-019-03204-0
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature14432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736772
    231 https://doi.org/10.1038/nature14432
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/news.2011.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056456268
    234 https://doi.org/10.1038/news.2011.319
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nri1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019686035
    237 https://doi.org/10.1038/nri1130
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/s41591-018-0135-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105917926
    240 https://doi.org/10.1038/s41591-018-0135-2
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/s41598-018-24516-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103565862
    243 https://doi.org/10.1038/s41598-018-24516-7
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/s41598-018-36340-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111618527
    246 https://doi.org/10.1038/s41598-018-36340-0
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/s41598-019-45577-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117491792
    249 https://doi.org/10.1038/s41598-019-45577-2
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/s12957-016-0975-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030376821
    252 https://doi.org/10.1186/s12957-016-0975-5
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/s12967-015-0451-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035172536
    255 https://doi.org/10.1186/s12967-015-0451-y
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/s13023-017-0649-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085932040
    258 https://doi.org/10.1186/s13023-017-0649-6
    259 rdf:type schema:CreativeWork
    260 grid-institutes:grid.240145.6 schema:alternateName Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
    261 Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Unit 422, P.O. Box 301402, 77230-1402, Houston, TX, USA
    262 Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
    263 schema:name Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
    264 Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Unit 422, P.O. Box 301402, 77230-1402, Houston, TX, USA
    265 Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA
    266 rdf:type schema:Organization
    267 grid-institutes:grid.425274.2 schema:alternateName CarThera, Institut du Cerveau Et de La Moelle épinière (ICM), 75013, Paris, France
    268 schema:name CarThera, Institut du Cerveau Et de La Moelle épinière (ICM), 75013, Paris, France
    269 rdf:type schema:Organization
    270 grid-institutes:grid.462844.8 schema:alternateName Department of Neurosurgery, Sorbonne Université, UPMC Univ Paris 06, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires La Pitié-Salpêtrière, Paris, France
    271 schema:name Department of Neurosurgery, Sorbonne Université, UPMC Univ Paris 06, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires La Pitié-Salpêtrière, Paris, France
    272 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...