Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-19

AUTHORS

Amaury De Barros, Justine Attal, Margaux Roques, Julien Nicolau, Jean-Christophe Sol, Elizabeth Cohen-Jonathan-Moyal, Franck-Emmanuel Roux

ABSTRACT

PURPOSE: Systematic pre-radiotherapy MRI in patients with newly resected glioblastoma (OMS 2016) sometimes reveals tumor growth in the period between surgery and radiotherapy. We evaluated the relation between early tumor growth and overall survival (OS) with the aim of finding predictors of regrowth. METHODS: Seventy-five patients from 25 to 84 years old (Median age 62 years) with preoperative, immediate postoperative, and preradiotherapy MRI were included. Volumetric measurements were made on each of the three MRI scans and clinical and molecular parameters were collected for each case. RESULTS: Fifty-four patients (72%) had an early regrowth with a median contrast enhancement volume of 3.61 cm3-range 0.12-71.93 cm3. The median OS was 24 months in patients with no early tumor growth and 17.1 months in those with early tumor regrowth (p = 0.0024). In the population with initial complete resection (27 patients), the median OS was 25.3 months (19 patients) in those with no early tumor growth between surgery and radiotherapy compared to 16.3 months (8 patients) in those with tumor regrowth. In multivariate analysis, the initial extent of resection (p < 0.001) and the delay between postoperative MRI and preradiotherapy MRI (p < 0.001) were significant independent prognostic factors of regrowth and of poorer outcome. CONCLUSIONS: We demonstrated that, in addition to the well known issue of incomplete resection, longer delays between surgery and adjuvant treatment is an independent factors of tumor regrowth and a risk factor of poorer outcomes for the patients. To overcome the delay factor, we suggest shortening the usual time between surgery and radiotherapy. More... »

PAGES

1-9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-019-03120-3

DOI

http://dx.doi.org/10.1007/s11060-019-03120-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112222117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30783874


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paul Sabatier University", 
          "id": "https://www.grid.ac/institutes/grid.15781.3a", 
          "name": [
            "Department of Neurosurgery, Toulouse University Hospital, Toulouse, France", 
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Barros", 
        "givenName": "Amaury", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Cancer Institute Toulouse Oncopole", 
          "id": "https://www.grid.ac/institutes/grid.488470.7", 
          "name": [
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France", 
            "Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncop\u00f4le, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Attal", 
        "givenName": "Justine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Toulouse", 
          "id": "https://www.grid.ac/institutes/grid.411175.7", 
          "name": [
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France", 
            "Neuroradiology Department, Toulouse University Hospital, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roques", 
        "givenName": "Margaux", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Sabatier University", 
          "id": "https://www.grid.ac/institutes/grid.15781.3a", 
          "name": [
            "Department of Neurosurgery, Toulouse University Hospital, Toulouse, France", 
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicolau", 
        "givenName": "Julien", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paul Sabatier University", 
          "id": "https://www.grid.ac/institutes/grid.15781.3a", 
          "name": [
            "Department of Neurosurgery, Toulouse University Hospital, Toulouse, France", 
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sol", 
        "givenName": "Jean-Christophe", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Cancer Institute Toulouse Oncopole", 
          "id": "https://www.grid.ac/institutes/grid.488470.7", 
          "name": [
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France", 
            "Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncop\u00f4le, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059, Toulouse, France", 
            "INSERM U1037, Centre de Recherche contre le Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen-Jonathan-Moyal", 
        "givenName": "Elizabeth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Purpan", 
          "id": "https://www.grid.ac/institutes/grid.414282.9", 
          "name": [
            "Department of Neurosurgery, Toulouse University Hospital, Toulouse, France", 
            "Universit\u00e9 Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France", 
            "CNRS UMR5549 Brain and Cognition (Cerco), H\u00f4pital Purpan, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roux", 
        "givenName": "Franck-Emmanuel", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pone.0016031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006319478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.10.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013950211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-016-2232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014162014", 
          "https://doi.org/10.1007/s11060-016-2232-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-016-2232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014162014", 
          "https://doi.org/10.1007/s11060-016-2232-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jon.12360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016910423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.1373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.1373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.1373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/not137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018612305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1545-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021788062", 
          "https://doi.org/10.1007/s00401-016-1545-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0720-048x(02)00027-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022207801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nor120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023408925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nic.2014.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025495746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-016-2110-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027064064", 
          "https://doi.org/10.1007/s11060-016-2110-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2016161382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030751264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-012-0997-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031209805", 
          "https://doi.org/10.1007/s11060-012-0997-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2007-016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031347372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-013-2895-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034718499", 
          "https://doi.org/10.1007/s00330-013-2895-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-016-4234-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037803740", 
          "https://doi.org/10.1007/s00330-016-4234-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.01.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038795558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043187529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2005.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047163501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nos268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051870488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3174/ajnr.a4917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053831169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3174/ajnr.a4917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053831169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13311-016-0507-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053876991", 
          "https://doi.org/10.1007/s13311-016-0507-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13311-016-0507-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053876991", 
          "https://doi.org/10.1007/s13311-016-0507-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2009-005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064414413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.2.jns10998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.2.jns10998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.2.jns10998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2011.2.jns10998", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071076491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.8.jns12234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.8.jns12234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2012.8.jns12234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2013.12.jns13184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2013.12.jns13184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2013.12.jns13184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071078498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.7.jns132449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.7.jns132449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2014.7.jns132449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071080499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2015.5.jns142087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071081608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2016.1.jns152153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071082176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.95.2.0190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.95.2.0190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2001.95.2.0190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071100026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2005.103.3.0428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071101715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuchi.2016.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083693257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuros/nyw174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083933806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2017160150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084494853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-017-0791-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084954374", 
          "https://doi.org/10.1186/s13014-017-0791-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-017-0791-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084954374", 
          "https://doi.org/10.1186/s13014-017-0791-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-017-2511-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085732352", 
          "https://doi.org/10.1007/s11060-017-2511-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-017-2511-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085732352", 
          "https://doi.org/10.1007/s11060-017-2511-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-017-2559-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090386399", 
          "https://doi.org/10.1007/s11060-017-2559-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-017-2559-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090386399", 
          "https://doi.org/10.1007/s11060-017-2559-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nox158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092560101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-017-2669-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099921162", 
          "https://doi.org/10.1007/s11060-017-2669-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fneur.2017.00660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100553689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2017170845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100565633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/noy053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103324700"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-19", 
    "datePublishedReg": "2019-02-19", 
    "description": "PURPOSE: Systematic pre-radiotherapy MRI in patients with newly resected glioblastoma (OMS 2016) sometimes reveals tumor growth in the period between surgery and radiotherapy. We evaluated the relation between early tumor growth and overall survival (OS) with the aim of finding predictors of regrowth.\nMETHODS: Seventy-five patients from 25 to 84\u00a0years old (Median age 62\u00a0years) with preoperative, immediate postoperative, and preradiotherapy MRI were included. Volumetric measurements were made on each of the three MRI scans and clinical and molecular parameters were collected for each case.\nRESULTS: Fifty-four patients (72%) had an early regrowth with a median contrast enhancement volume of 3.61\u00a0cm3-range 0.12-71.93\u00a0cm3. The median OS was 24\u00a0months in patients with no early tumor growth and 17.1\u00a0months in those with early tumor regrowth (p\u2009=\u20090.0024). In the population with initial complete resection (27 patients), the median OS was 25.3\u00a0months (19 patients) in those with no early tumor growth between surgery and radiotherapy compared to 16.3 months (8 patients) in those with tumor regrowth. In multivariate analysis, the initial extent of resection (p\u2009<\u20090.001) and the delay between postoperative MRI and preradiotherapy MRI (p\u2009<\u20090.001) were significant independent prognostic factors of regrowth and of poorer outcome.\nCONCLUSIONS: We demonstrated that, in addition to the well known issue of incomplete resection, longer delays between surgery and adjuvant treatment is an independent factors of tumor regrowth and a risk factor of poorer outcomes for the patients. To overcome the delay factor, we suggest shortening the usual time between surgery and radiotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11060-019-03120-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "type": "Periodical"
      }
    ], 
    "name": "Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma", 
    "pagination": "1-9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "12c122fd79f14d1825881e9d1de284e3cdeb56526f223eaf4e65ecd021368a5e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30783874"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309335"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11060-019-03120-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112222117"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11060-019-03120-3", 
      "https://app.dimensions.ai/details/publication/pub.1112222117"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47960_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11060-019-03120-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-019-03120-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-019-03120-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-019-03120-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-019-03120-3'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      69 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11060-019-03120-3 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Na82dfe6106e446659e2316a03d14d461
4 schema:citation sg:pub.10.1007/s00330-013-2895-x
5 sg:pub.10.1007/s00330-016-4234-5
6 sg:pub.10.1007/s00401-016-1545-1
7 sg:pub.10.1007/s11060-012-0997-y
8 sg:pub.10.1007/s11060-016-2110-4
9 sg:pub.10.1007/s11060-016-2232-8
10 sg:pub.10.1007/s11060-017-2511-z
11 sg:pub.10.1007/s11060-017-2559-9
12 sg:pub.10.1007/s11060-017-2669-4
13 sg:pub.10.1007/s13311-016-0507-6
14 sg:pub.10.1186/s13014-017-0791-2
15 https://doi.org/10.1001/jamaoncol.2016.1373
16 https://doi.org/10.1016/j.clon.2005.09.004
17 https://doi.org/10.1016/j.ijrobp.2007.01.064
18 https://doi.org/10.1016/j.ijrobp.2007.10.039
19 https://doi.org/10.1016/j.neuchi.2016.09.006
20 https://doi.org/10.1016/j.nic.2014.09.010
21 https://doi.org/10.1016/s0720-048x(02)00027-x
22 https://doi.org/10.1056/nejmoa043330
23 https://doi.org/10.1093/neuonc/nor120
24 https://doi.org/10.1093/neuonc/nos268
25 https://doi.org/10.1093/neuonc/not137
26 https://doi.org/10.1093/neuonc/nox158
27 https://doi.org/10.1093/neuonc/noy053
28 https://doi.org/10.1093/neuros/nyw174
29 https://doi.org/10.1111/jon.12360
30 https://doi.org/10.1148/radiol.2016161382
31 https://doi.org/10.1148/radiol.2017160150
32 https://doi.org/10.1148/radiol.2017170845
33 https://doi.org/10.1200/jco.2009.26.3541
34 https://doi.org/10.1215/15228517-2007-016
35 https://doi.org/10.1215/15228517-2009-005
36 https://doi.org/10.1371/journal.pone.0016031
37 https://doi.org/10.3171/2011.2.jns10998
38 https://doi.org/10.3171/2012.8.jns12234
39 https://doi.org/10.3171/2013.12.jns13184
40 https://doi.org/10.3171/2014.7.jns132449
41 https://doi.org/10.3171/2015.5.jns142087
42 https://doi.org/10.3171/2016.1.jns152153
43 https://doi.org/10.3171/jns.2001.95.2.0190
44 https://doi.org/10.3171/jns.2005.103.3.0428
45 https://doi.org/10.3174/ajnr.a4917
46 https://doi.org/10.3389/fneur.2017.00660
47 schema:datePublished 2019-02-19
48 schema:datePublishedReg 2019-02-19
49 schema:description PURPOSE: Systematic pre-radiotherapy MRI in patients with newly resected glioblastoma (OMS 2016) sometimes reveals tumor growth in the period between surgery and radiotherapy. We evaluated the relation between early tumor growth and overall survival (OS) with the aim of finding predictors of regrowth. METHODS: Seventy-five patients from 25 to 84 years old (Median age 62 years) with preoperative, immediate postoperative, and preradiotherapy MRI were included. Volumetric measurements were made on each of the three MRI scans and clinical and molecular parameters were collected for each case. RESULTS: Fifty-four patients (72%) had an early regrowth with a median contrast enhancement volume of 3.61 cm3-range 0.12-71.93 cm3. The median OS was 24 months in patients with no early tumor growth and 17.1 months in those with early tumor regrowth (p = 0.0024). In the population with initial complete resection (27 patients), the median OS was 25.3 months (19 patients) in those with no early tumor growth between surgery and radiotherapy compared to 16.3 months (8 patients) in those with tumor regrowth. In multivariate analysis, the initial extent of resection (p < 0.001) and the delay between postoperative MRI and preradiotherapy MRI (p < 0.001) were significant independent prognostic factors of regrowth and of poorer outcome. CONCLUSIONS: We demonstrated that, in addition to the well known issue of incomplete resection, longer delays between surgery and adjuvant treatment is an independent factors of tumor regrowth and a risk factor of poorer outcomes for the patients. To overcome the delay factor, we suggest shortening the usual time between surgery and radiotherapy.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf sg:journal.1094205
54 schema:name Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma
55 schema:pagination 1-9
56 schema:productId N27e51be600e04f7aa0eb5070eb5795e6
57 N50c0605e5932464f9f3a3d7fceac9a09
58 N89f04751e45b4390b2c776fc98abbf26
59 N8c41b4c442614edbb1320b3b30b5836b
60 Ndbae685618774eee8625f167a631a0b1
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112222117
62 https://doi.org/10.1007/s11060-019-03120-3
63 schema:sdDatePublished 2019-04-11T09:08
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nab6e2c37338f4784bd8f513899b2e03b
66 schema:url https://link.springer.com/10.1007%2Fs11060-019-03120-3
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N27e51be600e04f7aa0eb5070eb5795e6 schema:name dimensions_id
71 schema:value pub.1112222117
72 rdf:type schema:PropertyValue
73 N2a63f4c8b95249be9a8bfd22806422c7 rdf:first Nf2a6d11130e944bd8626accdea5b930c
74 rdf:rest N7edc38bbdc22467a9e4a9af2b033b4c7
75 N4db813e4a8e5448f8efb7b1087f1a29f schema:affiliation https://www.grid.ac/institutes/grid.411175.7
76 schema:familyName Roques
77 schema:givenName Margaux
78 rdf:type schema:Person
79 N50c0605e5932464f9f3a3d7fceac9a09 schema:name nlm_unique_id
80 schema:value 8309335
81 rdf:type schema:PropertyValue
82 N5a5950d1c2c3445696eb382d45a1e098 schema:affiliation https://www.grid.ac/institutes/grid.15781.3a
83 schema:familyName De Barros
84 schema:givenName Amaury
85 rdf:type schema:Person
86 N69eea93ed94a493f96d701d9677bc5c9 rdf:first Nfbee08f2c0f14160a66527825035346d
87 rdf:rest Nec0bd7b479394aeb8d5f3d8c6736ef54
88 N6cf30624058d4b0292603227854fd598 rdf:first N845eaf83fc164fe98b5c2e409767e437
89 rdf:rest N69eea93ed94a493f96d701d9677bc5c9
90 N7edc38bbdc22467a9e4a9af2b033b4c7 rdf:first N4db813e4a8e5448f8efb7b1087f1a29f
91 rdf:rest N6cf30624058d4b0292603227854fd598
92 N845eaf83fc164fe98b5c2e409767e437 schema:affiliation https://www.grid.ac/institutes/grid.15781.3a
93 schema:familyName Nicolau
94 schema:givenName Julien
95 rdf:type schema:Person
96 N89f04751e45b4390b2c776fc98abbf26 schema:name doi
97 schema:value 10.1007/s11060-019-03120-3
98 rdf:type schema:PropertyValue
99 N8c41b4c442614edbb1320b3b30b5836b schema:name pubmed_id
100 schema:value 30783874
101 rdf:type schema:PropertyValue
102 N964f068e873844b5964ac6e5faf94074 rdf:first Nb08dd8f73b7747f98ec0ce7a1c459052
103 rdf:rest rdf:nil
104 Na092ffd28a06427f8eba6ec3425c5b2e schema:affiliation https://www.grid.ac/institutes/grid.488470.7
105 schema:familyName Cohen-Jonathan-Moyal
106 schema:givenName Elizabeth
107 rdf:type schema:Person
108 Na82dfe6106e446659e2316a03d14d461 rdf:first N5a5950d1c2c3445696eb382d45a1e098
109 rdf:rest N2a63f4c8b95249be9a8bfd22806422c7
110 Nab6e2c37338f4784bd8f513899b2e03b schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 Nb08dd8f73b7747f98ec0ce7a1c459052 schema:affiliation https://www.grid.ac/institutes/grid.414282.9
113 schema:familyName Roux
114 schema:givenName Franck-Emmanuel
115 rdf:type schema:Person
116 Ndbae685618774eee8625f167a631a0b1 schema:name readcube_id
117 schema:value 12c122fd79f14d1825881e9d1de284e3cdeb56526f223eaf4e65ecd021368a5e
118 rdf:type schema:PropertyValue
119 Nec0bd7b479394aeb8d5f3d8c6736ef54 rdf:first Na092ffd28a06427f8eba6ec3425c5b2e
120 rdf:rest N964f068e873844b5964ac6e5faf94074
121 Nf2a6d11130e944bd8626accdea5b930c schema:affiliation https://www.grid.ac/institutes/grid.488470.7
122 schema:familyName Attal
123 schema:givenName Justine
124 rdf:type schema:Person
125 Nfbee08f2c0f14160a66527825035346d schema:affiliation https://www.grid.ac/institutes/grid.15781.3a
126 schema:familyName Sol
127 schema:givenName Jean-Christophe
128 rdf:type schema:Person
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
133 schema:name Clinical Sciences
134 rdf:type schema:DefinedTerm
135 sg:journal.1094205 schema:issn 0167-594X
136 1573-7373
137 schema:name Journal of Neuro-Oncology
138 rdf:type schema:Periodical
139 sg:pub.10.1007/s00330-013-2895-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034718499
140 https://doi.org/10.1007/s00330-013-2895-x
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s00330-016-4234-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037803740
143 https://doi.org/10.1007/s00330-016-4234-5
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/s00401-016-1545-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021788062
146 https://doi.org/10.1007/s00401-016-1545-1
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s11060-012-0997-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031209805
149 https://doi.org/10.1007/s11060-012-0997-y
150 rdf:type schema:CreativeWork
151 sg:pub.10.1007/s11060-016-2110-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027064064
152 https://doi.org/10.1007/s11060-016-2110-4
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s11060-016-2232-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014162014
155 https://doi.org/10.1007/s11060-016-2232-8
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/s11060-017-2511-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085732352
158 https://doi.org/10.1007/s11060-017-2511-z
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s11060-017-2559-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090386399
161 https://doi.org/10.1007/s11060-017-2559-9
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s11060-017-2669-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099921162
164 https://doi.org/10.1007/s11060-017-2669-4
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s13311-016-0507-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053876991
167 https://doi.org/10.1007/s13311-016-0507-6
168 rdf:type schema:CreativeWork
169 sg:pub.10.1186/s13014-017-0791-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084954374
170 https://doi.org/10.1186/s13014-017-0791-2
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1001/jamaoncol.2016.1373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017485928
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.clon.2005.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047163501
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.ijrobp.2007.01.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038795558
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.ijrobp.2007.10.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013950211
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.neuchi.2016.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083693257
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.nic.2014.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025495746
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/s0720-048x(02)00027-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022207801
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1093/neuonc/nor120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023408925
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/neuonc/nos268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051870488
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1093/neuonc/not137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018612305
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1093/neuonc/nox158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092560101
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1093/neuonc/noy053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103324700
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1093/neuros/nyw174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083933806
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1111/jon.12360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016910423
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1148/radiol.2016161382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030751264
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1148/radiol.2017160150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084494853
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1148/radiol.2017170845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100565633
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1200/jco.2009.26.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043187529
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1215/15228517-2007-016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031347372
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1215/15228517-2009-005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064414413
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1371/journal.pone.0016031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006319478
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3171/2011.2.jns10998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071076491
217 rdf:type schema:CreativeWork
218 https://doi.org/10.3171/2012.8.jns12234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071078029
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3171/2013.12.jns13184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071078498
221 rdf:type schema:CreativeWork
222 https://doi.org/10.3171/2014.7.jns132449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071080499
223 rdf:type schema:CreativeWork
224 https://doi.org/10.3171/2015.5.jns142087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071081608
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3171/2016.1.jns152153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071082176
227 rdf:type schema:CreativeWork
228 https://doi.org/10.3171/jns.2001.95.2.0190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071100026
229 rdf:type schema:CreativeWork
230 https://doi.org/10.3171/jns.2005.103.3.0428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071101715
231 rdf:type schema:CreativeWork
232 https://doi.org/10.3174/ajnr.a4917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053831169
233 rdf:type schema:CreativeWork
234 https://doi.org/10.3389/fneur.2017.00660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100553689
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.15781.3a schema:alternateName Paul Sabatier University
237 schema:name Department of Neurosurgery, Toulouse University Hospital, Toulouse, France
238 Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.411175.7 schema:alternateName Centre Hospitalier Universitaire de Toulouse
241 schema:name Neuroradiology Department, Toulouse University Hospital, Toulouse, France
242 Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.414282.9 schema:alternateName Hôpital Purpan
245 schema:name CNRS UMR5549 Brain and Cognition (Cerco), Hôpital Purpan, Toulouse, France
246 Department of Neurosurgery, Toulouse University Hospital, Toulouse, France
247 Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.488470.7 schema:alternateName University Cancer Institute Toulouse Oncopole
250 schema:name Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncopôle, 1 Avenue Irène Joliot-Curie, 31059, Toulouse, France
251 INSERM U1037, Centre de Recherche contre le Cancer de Toulouse, 1 Avenue Irène Joliot-Curie, 31059, Toulouse, France
252 Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062, Toulouse, France
253 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...