Effect of lapatinib on meningioma growth in adults with neurofibromatosis type 2 View Full Text


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Article Info

DATE

2018-09

AUTHORS

Diana S. Osorio, Jessica Hu, Carole Mitchell, Jeffrey C. Allen, Joseph Stanek, Mari Hagiwara, Matthias A. Karajannis

ABSTRACT

INTRODUCTION: Epidermal growth factor receptors EGFR and ErbB2 are overexpressed in schwannomas and meningiomas. Preclinical and clinical data indicate that lapatinib, an EGFR/ErbB2 inhibitor, has antitumor activity against vestibular schwannomas in neurofibromatosis type 2 (NF2) patients. Its antitumor activity against meningiomas, however, is unknown. METHODS: We conducted a retrospective review of patients with NF2 and progressive vestibular schwannomas treated on a phase 2 clinical trial with lapatinib (NCT00973739). We included patients with at least one volumetrically measurable meningioma (> 0.5 cm3) who received at least five 28-day courses of treatment. Patients received lapatinib 1500 mg daily. Meningioma response was assessed using 3-dimensional MRI volumetrics. Progressive meningioma growth and response were defined as + 20 and - 20% change in tumor volume from baseline, respectively. Off-treatment was defined as any period > 5 months without lapatinib. RESULTS: Eight patients (ages: 20-58 years) who met criteria had 17 evaluable meningiomas with a combined volume of 61.35 cc at baseline, 61.17 cc during treatment, and 108.86 cc (+ 77.44% change) off-treatment, p = 0.0033. Median time on-treatment and off-treatment was 15.5 and 16.7 months, respectively. On-treatment mean and median annualized growth rates were 10.67 and 1.32%, respectively. Off-treatment mean and median annualized growth rates were 20.05 and 10.42%, respectively. The best volumetric response was - 26.1% after 23 months on lapatinib. Two tumors increased > 20% volumetrically on-treatment, compared to eight tumors off-treatment. CONCLUSIONS: These data suggest that lapatinib may have growth-inhibitory effects on meningiomas in NF2 patients, and support prospective studies of lapatinib for NF2 patients with progressive meningiomas. More... »

PAGES

749-755

References to SciGraph publications

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    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-018-2922-5

    DOI

    http://dx.doi.org/10.1007/s11060-018-2922-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104476321

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29948766


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