Tumor growth dynamics in serially-imaged low-grade glioma patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Chloe Gui, Suzanne E. Kosteniuk, Jonathan C. Lau, Joseph F. Megyesi

ABSTRACT

BACKGROUND: Diffuse low-grade gliomas (LGGs) are infiltrative, slow-growing primary brain tumors that remain relatively asymptomatic for long periods of time before progressing into aggressive and fatal high-grade gliomas. METHODS: We retrospectively identified LGG patients with numerous (≥ 8) serial magnetic resonance imaging (MRI) studies. Tumor volumes were measured by manual segmentation on serial imaging to study the natural history and growth of the lesion. Patient demographic information, tumor characteristics, and histological data were collected from electronic medical records and paper charts. RESULTS: Out of 74 LGG patients, 10 patients (13.5%) were identified to meet the study criteria with number of MRIs acquired ranging from 8 to 18 (median, 11.5) over a median of 79.7 months (range 39.8-113.8 months). Tumor diameter increased at a median of 2.17 mm/year in a linear trajectory. Cox regression analysis revealed that initial tumor volume was an independent predictor of time to clinical intervention, and Mann-Whitney U test found that patients younger than 50 years old had significantly slower-growing tumors. Clinical intervention was more likely for tumors above a volume threshold of 73.6 mL. CONCLUSION: We retrospectively analyzed the natural history of LGGs of patients managed at a single institution with numerous serial MRI scans. Comparisons of our cohort to the literature suggest that this is a subset of particularly slow-growing and low-risk tumors. More... »

PAGES

167-175

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-018-2857-x

DOI

http://dx.doi.org/10.1007/s11060-018-2857-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103192529

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29633111


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275 https://www.grid.ac/institutes/grid.449710.f schema:alternateName University Hospital
276 schema:name Department of Clinical Neurological Sciences (Neurosurgery), Western University, London, ON, Canada
277 Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
278 London Health Sciences Centre, University Hospital, 339 Windermere Road, N6A 5A5, London, ON, Canada
279 rdf:type schema:Organization
 




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