Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-07

AUTHORS

Christos Christodoulou, Anna Kalogera-Fountzila, Vasilios Karavasilis, George Kouvatseas, Christos N. Papandreou, Epaminontas Samantas, Kalliopi Varaki, Georgios Papadopoulos, Mattheos Bobos, Grigorios Rallis, Evangelia Razis, Athina Goudopoulou, Konstantine T. Kalogeras, Konstantinos N. Syrigos, George Fountzilas

ABSTRACT

Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing breast cancer. It also appears to sensitize EGFR-expressing cell lines to radiation. To evaluate the efficacy of lapatinib in combination with whole brain radiotherapy (WBRT) in patients with brain metastases from non-small cell lung cancer (NSCLC) and breast cancer, as assessed by volumetric analysis by MRI. 81 patients were treated with WBRT (30 Gy in ten fractions) in combination with lapatinib 1250 mg once daily, followed by lapatinib 1500 mg once daily for a total 6 weeks. 21 patients had primary breast cancer and 60 patients NSCLC. Pre- and post-treatment MRI scans in a compact disk for central volumetric assessment were available for 43 patients. 27 patients (62.8%) achieved partial response, 15 patients (34.9%) had stable disease and only one patient (2.3%) had disease progression. Response was not associated to EGFR protein expression. All 81 patients were assessed for safety. The large majority of the adverse events were mild. Eight deaths occurred, four of which were considered related to the study drugs but there were also other contributing factors. Nine cases of serious infections were observed in eight patients, but they were also receiving dexamethasone. Lapatinib in combination with WBRT in patients with brain metastases from breast cancer and NSCLC is a feasible approach that can be further studied in larger clinical trials. More... »

PAGES

443-451

Journal

TITLE

Journal of Neuro-Oncology

ISSUE

2

VOLUME

134

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-017-2548-z

DOI

http://dx.doi.org/10.1007/s11060-017-2548-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090381678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28687923


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Non-Small-Cell Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lapatinib", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Department of Medical Oncology, Metropolitan Hospital, 9 Eth. Makariou Str., 18547, Piraeus, Greece", 
          "id": "http://www.grid.ac/institutes/grid.415451.0", 
          "name": [
            "Second Department of Medical Oncology, Metropolitan Hospital, 9 Eth. Makariou Str., 18547, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christodoulou", 
        "givenName": "Christos", 
        "id": "sg:person.011651226237.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651226237.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalogera-Fountzila", 
        "givenName": "Anna", 
        "id": "sg:person.0653557131.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653557131.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.4793.9", 
          "name": [
            "Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karavasilis", 
        "givenName": "Vasilios", 
        "id": "sg:person.0654575012.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654575012.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Data Specialists Ltd, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Health Data Specialists Ltd, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kouvatseas", 
        "givenName": "George", 
        "id": "sg:person.01132157650.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132157650.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece", 
          "id": "http://www.grid.ac/institutes/grid.411299.6", 
          "name": [
            "Department of Medical Oncology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papandreou", 
        "givenName": "Christos N.", 
        "id": "sg:person.0673405345.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673405345.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.470050.6", 
          "name": [
            "Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samantas", 
        "givenName": "Epaminontas", 
        "id": "sg:person.01326021733.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326021733.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Metropolitan Hospital, Piraeus, Greece", 
          "id": "http://www.grid.ac/institutes/grid.415451.0", 
          "name": [
            "Department of Radiology, Metropolitan Hospital, Piraeus, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varaki", 
        "givenName": "Kalliopi", 
        "id": "sg:person.01060673354.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060673354.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papadopoulos", 
        "givenName": "Georgios", 
        "id": "sg:person.0576374523.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576374523.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.4793.9", 
          "name": [
            "Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bobos", 
        "givenName": "Mattheos", 
        "id": "sg:person.01267365136.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267365136.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.4793.9", 
          "name": [
            "Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rallis", 
        "givenName": "Grigorios", 
        "id": "sg:person.01331771255.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331771255.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.413693.a", 
          "name": [
            "Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Razis", 
        "givenName": "Evangelia", 
        "id": "sg:person.0755474415.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755474415.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmacovigilance Section, Hellenic Cooperative Oncology Group, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.476341.3", 
          "name": [
            "Pharmacovigilance Section, Hellenic Cooperative Oncology Group, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goudopoulou", 
        "givenName": "Athina", 
        "id": "sg:person.01336315466.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336315466.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Research Section, Hellenic Cooperative Oncology Group, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.476341.3", 
          "name": [
            "Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece", 
            "Translational Research Section, Hellenic Cooperative Oncology Group, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalogeras", 
        "givenName": "Konstantine T.", 
        "id": "sg:person.01145365443.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145365443.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Medicine, National and Kapodistrian University of Athens, Athens, Greece", 
          "id": "http://www.grid.ac/institutes/grid.5216.0", 
          "name": [
            "School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Syrigos", 
        "givenName": "Konstantinos N.", 
        "id": "sg:person.015363113164.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015363113164.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aristotle University of Thessaloniki, Thessaloniki, Greece", 
          "id": "http://www.grid.ac/institutes/grid.4793.9", 
          "name": [
            "Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece", 
            "Aristotle University of Thessaloniki, Thessaloniki, Greece"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fountzilas", 
        "givenName": "George", 
        "id": "sg:person.0601312360.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601312360.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11060-004-9176-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012108006", 
          "https://doi.org/10.1007/s11060-004-9176-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-011-1730-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019340746", 
          "https://doi.org/10.1007/s00280-011-1730-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-013-2754-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011277554", 
          "https://doi.org/10.1007/s10549-013-2754-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050596563", 
          "https://doi.org/10.1038/sj.onc.1205794"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07-07", 
    "datePublishedReg": "2017-07-07", 
    "description": "Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing breast cancer. It also appears to sensitize EGFR-expressing cell lines to radiation. To evaluate the efficacy of lapatinib in combination with whole brain radiotherapy (WBRT) in patients with brain metastases from non-small cell lung cancer (NSCLC) and breast cancer, as assessed by volumetric analysis by MRI. 81 patients were treated with WBRT (30\u00a0Gy in ten fractions) in combination with lapatinib 1250\u00a0mg once daily, followed by lapatinib 1500\u00a0mg once daily for a total 6\u00a0weeks. 21 patients had primary breast cancer and 60 patients NSCLC. Pre- and post-treatment MRI scans in a compact disk for central volumetric assessment were available for 43 patients. 27 patients (62.8%) achieved partial response, 15 patients (34.9%) had stable disease and only one patient (2.3%) had disease progression. Response was not associated to EGFR protein expression. All 81 patients were assessed for safety. The large majority of the adverse events were mild. Eight deaths occurred, four of which were considered related to the study drugs but there were also other contributing factors. Nine cases of serious infections were observed in eight patients, but they were also receiving dexamethasone. Lapatinib in combination with WBRT in patients with brain metastases from breast cancer and NSCLC is a feasible approach that can be further studied in larger clinical trials.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11060-017-2548-z", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "134"
      }
    ], 
    "keywords": [
      "non-small cell lung cancer", 
      "whole brain radiotherapy", 
      "cell lung cancer", 
      "brain metastases", 
      "breast cancer", 
      "brain radiotherapy", 
      "lung cancer", 
      "patients non-small cell lung cancer", 
      "Hellenic Cooperative Oncology Group", 
      "phase II study", 
      "post-treatment MRI", 
      "efficacy of lapatinib", 
      "primary breast cancer", 
      "Cooperative Oncology Group", 
      "large clinical trials", 
      "tyrosine kinase inhibitors", 
      "EGFR protein expression", 
      "HER2 tyrosine kinase", 
      "lapatinib 1250", 
      "lapatinib 1500", 
      "stable disease", 
      "study drug", 
      "partial response", 
      "adverse events", 
      "II study", 
      "Oncology Group", 
      "serious infections", 
      "disease progression", 
      "clinical trials", 
      "patients", 
      "metastasis", 
      "volumetric assessment", 
      "cancer", 
      "EGFR/HER2 tyrosine kinases", 
      "kinase inhibitors", 
      "lapatinib", 
      "protein expression", 
      "dual inhibitor", 
      "volumetric analysis", 
      "cell lines", 
      "radiotherapy", 
      "MRI", 
      "tyrosine kinase", 
      "inhibitors", 
      "large majority", 
      "malignancy", 
      "HER2", 
      "EGFR", 
      "infection", 
      "breast", 
      "disease", 
      "progression", 
      "trials", 
      "weeks", 
      "response", 
      "drugs", 
      "efficacy", 
      "death", 
      "feasible approach", 
      "safety", 
      "combination", 
      "group", 
      "majority", 
      "expression", 
      "small molecules", 
      "kinase", 
      "assessment", 
      "factors", 
      "cases", 
      "study", 
      "events", 
      "lines", 
      "effectiveness", 
      "analysis", 
      "molecules", 
      "radiation", 
      "disk", 
      "approach", 
      "compact disc"
    ], 
    "name": "Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG)", 
    "pagination": "443-451", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090381678"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11060-017-2548-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28687923"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11060-017-2548-z", 
      "https://app.dimensions.ai/details/publication/pub.1090381678"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_748.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11060-017-2548-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-017-2548-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-017-2548-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-017-2548-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-017-2548-z'


 

This table displays all metadata directly associated to this object as RDF triples.

362 TRIPLES      21 PREDICATES      127 URIs      115 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11060-017-2548-z schema:about N19ec0280acea47a2bcc6d071509d9ad1
2 N1a69bb52d214465598c7aadec3d14db0
3 N1f9c4bd243504b0190aa3f4cf2773cde
4 N2b04709bb025437892bb5e147f2704db
5 N2f62b738cd7c42b09214137c4c12dfee
6 N3c1b1075c3ed4af980bf9881566755ac
7 N3dd4c27e4c7f46d79983aa6cb0ca35f8
8 N466d923ac07643d5a197bf2ca937fcba
9 N46a75e7c7f6e49e2bf5c5e14a1ffe912
10 N5e46e8eaacc94535b9efddda0fab95be
11 N680d6cba1e2b4ef2a65d58206e0dcef0
12 N7d663f8a3c524947ac283b0083501b8e
13 N95d0c534b6cc4ec4bf4cea475c9a9c8c
14 Nabf8b349d1b545288ed7b8375b221e45
15 Nc806fc0beb724a7cacdbfa123735ffa5
16 Ne081fa7b2bbb4fe1b7ab3ea87f145113
17 Ne4d96cef2d584a309529bda552259603
18 Ne64a14fdaf6a4a419fe16d9d67d3109a
19 Ne7f7634a6885456baac8bbda412f4850
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N1825e99520054f8eb1482475c989590f
23 schema:citation sg:pub.10.1007/s00280-011-1730-9
24 sg:pub.10.1007/s10549-013-2754-0
25 sg:pub.10.1007/s11060-004-9176-0
26 sg:pub.10.1038/sj.onc.1205794
27 schema:datePublished 2017-07-07
28 schema:datePublishedReg 2017-07-07
29 schema:description Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing breast cancer. It also appears to sensitize EGFR-expressing cell lines to radiation. To evaluate the efficacy of lapatinib in combination with whole brain radiotherapy (WBRT) in patients with brain metastases from non-small cell lung cancer (NSCLC) and breast cancer, as assessed by volumetric analysis by MRI. 81 patients were treated with WBRT (30 Gy in ten fractions) in combination with lapatinib 1250 mg once daily, followed by lapatinib 1500 mg once daily for a total 6 weeks. 21 patients had primary breast cancer and 60 patients NSCLC. Pre- and post-treatment MRI scans in a compact disk for central volumetric assessment were available for 43 patients. 27 patients (62.8%) achieved partial response, 15 patients (34.9%) had stable disease and only one patient (2.3%) had disease progression. Response was not associated to EGFR protein expression. All 81 patients were assessed for safety. The large majority of the adverse events were mild. Eight deaths occurred, four of which were considered related to the study drugs but there were also other contributing factors. Nine cases of serious infections were observed in eight patients, but they were also receiving dexamethasone. Lapatinib in combination with WBRT in patients with brain metastases from breast cancer and NSCLC is a feasible approach that can be further studied in larger clinical trials.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N12418a02b6034132aecf30fbab13d393
33 Nd730805b46a14ae0b0a2de092f0f69cf
34 sg:journal.1094205
35 schema:keywords Cooperative Oncology Group
36 EGFR
37 EGFR protein expression
38 EGFR/HER2 tyrosine kinases
39 HER2
40 HER2 tyrosine kinase
41 Hellenic Cooperative Oncology Group
42 II study
43 MRI
44 Oncology Group
45 adverse events
46 analysis
47 approach
48 assessment
49 brain metastases
50 brain radiotherapy
51 breast
52 breast cancer
53 cancer
54 cases
55 cell lines
56 cell lung cancer
57 clinical trials
58 combination
59 compact disc
60 death
61 disease
62 disease progression
63 disk
64 drugs
65 dual inhibitor
66 effectiveness
67 efficacy
68 efficacy of lapatinib
69 events
70 expression
71 factors
72 feasible approach
73 group
74 infection
75 inhibitors
76 kinase
77 kinase inhibitors
78 lapatinib
79 lapatinib 1250
80 lapatinib 1500
81 large clinical trials
82 large majority
83 lines
84 lung cancer
85 majority
86 malignancy
87 metastasis
88 molecules
89 non-small cell lung cancer
90 partial response
91 patients
92 patients non-small cell lung cancer
93 phase II study
94 post-treatment MRI
95 primary breast cancer
96 progression
97 protein expression
98 radiation
99 radiotherapy
100 response
101 safety
102 serious infections
103 small molecules
104 stable disease
105 study
106 study drug
107 trials
108 tyrosine kinase
109 tyrosine kinase inhibitors
110 volumetric analysis
111 volumetric assessment
112 weeks
113 whole brain radiotherapy
114 schema:name Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG)
115 schema:pagination 443-451
116 schema:productId N34662c5a7d734d8eb364e379309b4d97
117 N71fa469e99ed4936952ae6d263c8fe05
118 N82c51129da8c42519a4c6d485fc92cb4
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090381678
120 https://doi.org/10.1007/s11060-017-2548-z
121 schema:sdDatePublished 2022-12-01T06:37
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher Na1e8634e24494ef099de6143a02af2f6
124 schema:url https://doi.org/10.1007/s11060-017-2548-z
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N014874b7290a45a5a7e015ddc416e2e2 rdf:first sg:person.0673405345.51
129 rdf:rest N276f48be0ae5493fb5ff886a1da69f6d
130 N12418a02b6034132aecf30fbab13d393 schema:issueNumber 2
131 rdf:type schema:PublicationIssue
132 N1825e99520054f8eb1482475c989590f rdf:first sg:person.011651226237.29
133 rdf:rest Na0bab502d49b4390beaae20190f7c1cb
134 N19ec0280acea47a2bcc6d071509d9ad1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Aged
136 rdf:type schema:DefinedTerm
137 N1a69bb52d214465598c7aadec3d14db0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Female
139 rdf:type schema:DefinedTerm
140 N1f9c4bd243504b0190aa3f4cf2773cde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Treatment Outcome
142 rdf:type schema:DefinedTerm
143 N276f48be0ae5493fb5ff886a1da69f6d rdf:first sg:person.01326021733.68
144 rdf:rest Nfee9c3d8f6e44ec491d0ec503f12eff5
145 N2b04709bb025437892bb5e147f2704db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 N2f62b738cd7c42b09214137c4c12dfee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Chemoradiotherapy
150 rdf:type schema:DefinedTerm
151 N34662c5a7d734d8eb364e379309b4d97 schema:name dimensions_id
152 schema:value pub.1090381678
153 rdf:type schema:PropertyValue
154 N3658e722e4344cc2b41c6c5f22e771d3 rdf:first sg:person.0601312360.10
155 rdf:rest rdf:nil
156 N3c1b1075c3ed4af980bf9881566755ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Lapatinib
158 rdf:type schema:DefinedTerm
159 N3dd4c27e4c7f46d79983aa6cb0ca35f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Brain Neoplasms
161 rdf:type schema:DefinedTerm
162 N434d6cfccf9b4f07a10acce135ea95fe rdf:first sg:person.01132157650.24
163 rdf:rest N014874b7290a45a5a7e015ddc416e2e2
164 N466d923ac07643d5a197bf2ca937fcba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Adult
166 rdf:type schema:DefinedTerm
167 N46a75e7c7f6e49e2bf5c5e14a1ffe912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Follow-Up Studies
169 rdf:type schema:DefinedTerm
170 N5c1208e72eb947ba860881d62a720190 rdf:first sg:person.0576374523.72
171 rdf:rest N7fba0cfb0ec74ce3a4afa3b1f805c595
172 N5e46e8eaacc94535b9efddda0fab95be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Antineoplastic Agents
174 rdf:type schema:DefinedTerm
175 N680d6cba1e2b4ef2a65d58206e0dcef0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Aged, 80 and over
177 rdf:type schema:DefinedTerm
178 N7180a4dfa2364d2284e24cbfa4a2c186 rdf:first sg:person.015363113164.65
179 rdf:rest N3658e722e4344cc2b41c6c5f22e771d3
180 N71fa469e99ed4936952ae6d263c8fe05 schema:name pubmed_id
181 schema:value 28687923
182 rdf:type schema:PropertyValue
183 N7d663f8a3c524947ac283b0083501b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Breast Neoplasms
185 rdf:type schema:DefinedTerm
186 N7fba0cfb0ec74ce3a4afa3b1f805c595 rdf:first sg:person.01267365136.72
187 rdf:rest Nee4a846949cb4dce8a067137b25191a9
188 N82c51129da8c42519a4c6d485fc92cb4 schema:name doi
189 schema:value 10.1007/s11060-017-2548-z
190 rdf:type schema:PropertyValue
191 N8e294de8cb8f4bb5b90dc80a4c8742ff rdf:first sg:person.01336315466.48
192 rdf:rest Ne7b3f4fbb0e34e95b5606d9115f88910
193 N95d0c534b6cc4ec4bf4cea475c9a9c8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Brain
195 rdf:type schema:DefinedTerm
196 Na0bab502d49b4390beaae20190f7c1cb rdf:first sg:person.0653557131.11
197 rdf:rest Nb69d8de7841647cd85c2164b5373d45e
198 Na1e8634e24494ef099de6143a02af2f6 schema:name Springer Nature - SN SciGraph project
199 rdf:type schema:Organization
200 Nabf8b349d1b545288ed7b8375b221e45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Middle Aged
202 rdf:type schema:DefinedTerm
203 Nb69d8de7841647cd85c2164b5373d45e rdf:first sg:person.0654575012.61
204 rdf:rest N434d6cfccf9b4f07a10acce135ea95fe
205 Nb701e5ec4ccb4bb39901bf1183c6d10c rdf:first sg:person.0755474415.03
206 rdf:rest N8e294de8cb8f4bb5b90dc80a4c8742ff
207 Nc806fc0beb724a7cacdbfa123735ffa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Lung Neoplasms
209 rdf:type schema:DefinedTerm
210 Nd730805b46a14ae0b0a2de092f0f69cf schema:volumeNumber 134
211 rdf:type schema:PublicationVolume
212 Ne081fa7b2bbb4fe1b7ab3ea87f145113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Disease Progression
214 rdf:type schema:DefinedTerm
215 Ne4d96cef2d584a309529bda552259603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Male
217 rdf:type schema:DefinedTerm
218 Ne64a14fdaf6a4a419fe16d9d67d3109a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Quinazolines
220 rdf:type schema:DefinedTerm
221 Ne7b3f4fbb0e34e95b5606d9115f88910 rdf:first sg:person.01145365443.52
222 rdf:rest N7180a4dfa2364d2284e24cbfa4a2c186
223 Ne7f7634a6885456baac8bbda412f4850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Carcinoma, Non-Small-Cell Lung
225 rdf:type schema:DefinedTerm
226 Nee4a846949cb4dce8a067137b25191a9 rdf:first sg:person.01331771255.28
227 rdf:rest Nb701e5ec4ccb4bb39901bf1183c6d10c
228 Nfee9c3d8f6e44ec491d0ec503f12eff5 rdf:first sg:person.01060673354.67
229 rdf:rest N5c1208e72eb947ba860881d62a720190
230 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
231 schema:name Medical and Health Sciences
232 rdf:type schema:DefinedTerm
233 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
234 schema:name Oncology and Carcinogenesis
235 rdf:type schema:DefinedTerm
236 sg:journal.1094205 schema:issn 0167-594X
237 1573-7373
238 schema:name Journal of Neuro-Oncology
239 schema:publisher Springer Nature
240 rdf:type schema:Periodical
241 sg:person.01060673354.67 schema:affiliation grid-institutes:grid.415451.0
242 schema:familyName Varaki
243 schema:givenName Kalliopi
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060673354.67
245 rdf:type schema:Person
246 sg:person.01132157650.24 schema:affiliation grid-institutes:None
247 schema:familyName Kouvatseas
248 schema:givenName George
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132157650.24
250 rdf:type schema:Person
251 sg:person.01145365443.52 schema:affiliation grid-institutes:grid.476341.3
252 schema:familyName Kalogeras
253 schema:givenName Konstantine T.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145365443.52
255 rdf:type schema:Person
256 sg:person.011651226237.29 schema:affiliation grid-institutes:grid.415451.0
257 schema:familyName Christodoulou
258 schema:givenName Christos
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651226237.29
260 rdf:type schema:Person
261 sg:person.01267365136.72 schema:affiliation grid-institutes:grid.4793.9
262 schema:familyName Bobos
263 schema:givenName Mattheos
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267365136.72
265 rdf:type schema:Person
266 sg:person.01326021733.68 schema:affiliation grid-institutes:grid.470050.6
267 schema:familyName Samantas
268 schema:givenName Epaminontas
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326021733.68
270 rdf:type schema:Person
271 sg:person.01331771255.28 schema:affiliation grid-institutes:grid.4793.9
272 schema:familyName Rallis
273 schema:givenName Grigorios
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331771255.28
275 rdf:type schema:Person
276 sg:person.01336315466.48 schema:affiliation grid-institutes:grid.476341.3
277 schema:familyName Goudopoulou
278 schema:givenName Athina
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336315466.48
280 rdf:type schema:Person
281 sg:person.015363113164.65 schema:affiliation grid-institutes:grid.5216.0
282 schema:familyName Syrigos
283 schema:givenName Konstantinos N.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015363113164.65
285 rdf:type schema:Person
286 sg:person.0576374523.72 schema:affiliation grid-institutes:None
287 schema:familyName Papadopoulos
288 schema:givenName Georgios
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576374523.72
290 rdf:type schema:Person
291 sg:person.0601312360.10 schema:affiliation grid-institutes:grid.4793.9
292 schema:familyName Fountzilas
293 schema:givenName George
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601312360.10
295 rdf:type schema:Person
296 sg:person.0653557131.11 schema:affiliation grid-institutes:None
297 schema:familyName Kalogera-Fountzila
298 schema:givenName Anna
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653557131.11
300 rdf:type schema:Person
301 sg:person.0654575012.61 schema:affiliation grid-institutes:grid.4793.9
302 schema:familyName Karavasilis
303 schema:givenName Vasilios
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654575012.61
305 rdf:type schema:Person
306 sg:person.0673405345.51 schema:affiliation grid-institutes:grid.411299.6
307 schema:familyName Papandreou
308 schema:givenName Christos N.
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673405345.51
310 rdf:type schema:Person
311 sg:person.0755474415.03 schema:affiliation grid-institutes:grid.413693.a
312 schema:familyName Razis
313 schema:givenName Evangelia
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755474415.03
315 rdf:type schema:Person
316 sg:pub.10.1007/s00280-011-1730-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019340746
317 https://doi.org/10.1007/s00280-011-1730-9
318 rdf:type schema:CreativeWork
319 sg:pub.10.1007/s10549-013-2754-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011277554
320 https://doi.org/10.1007/s10549-013-2754-0
321 rdf:type schema:CreativeWork
322 sg:pub.10.1007/s11060-004-9176-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012108006
323 https://doi.org/10.1007/s11060-004-9176-0
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/sj.onc.1205794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050596563
326 https://doi.org/10.1038/sj.onc.1205794
327 rdf:type schema:CreativeWork
328 grid-institutes:None schema:alternateName Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
329 Health Data Specialists Ltd, Athens, Greece
330 schema:name Department of Radiology, Faculty of Medicine, School of Health Sciences, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
331 Health Data Specialists Ltd, Athens, Greece
332 rdf:type schema:Organization
333 grid-institutes:grid.411299.6 schema:alternateName Department of Medical Oncology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece
334 schema:name Department of Medical Oncology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece
335 rdf:type schema:Organization
336 grid-institutes:grid.413693.a schema:alternateName Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece
337 schema:name Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece
338 rdf:type schema:Organization
339 grid-institutes:grid.415451.0 schema:alternateName Department of Radiology, Metropolitan Hospital, Piraeus, Greece
340 Second Department of Medical Oncology, Metropolitan Hospital, 9 Eth. Makariou Str., 18547, Piraeus, Greece
341 schema:name Department of Radiology, Metropolitan Hospital, Piraeus, Greece
342 Second Department of Medical Oncology, Metropolitan Hospital, 9 Eth. Makariou Str., 18547, Piraeus, Greece
343 rdf:type schema:Organization
344 grid-institutes:grid.470050.6 schema:alternateName Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece
345 schema:name Third Department of Medical Oncology, Agii Anargiri Cancer Hospital, Athens, Greece
346 rdf:type schema:Organization
347 grid-institutes:grid.476341.3 schema:alternateName Pharmacovigilance Section, Hellenic Cooperative Oncology Group, Athens, Greece
348 Translational Research Section, Hellenic Cooperative Oncology Group, Athens, Greece
349 schema:name Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece
350 Pharmacovigilance Section, Hellenic Cooperative Oncology Group, Athens, Greece
351 Translational Research Section, Hellenic Cooperative Oncology Group, Athens, Greece
352 rdf:type schema:Organization
353 grid-institutes:grid.4793.9 schema:alternateName Aristotle University of Thessaloniki, Thessaloniki, Greece
354 Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
355 Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece
356 schema:name Aristotle University of Thessaloniki, Thessaloniki, Greece
357 Department of Medical Oncology, Faculty of Medicine, School of Health Sciences, Papageorgiou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
358 Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece
359 rdf:type schema:Organization
360 grid-institutes:grid.5216.0 schema:alternateName School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
361 schema:name School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
362 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...