Assessment of function and quality of life in a phase II multi-institutional clinical trial of fractionated simultaneous in-field boost radiotherapy ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

Glenn Bauman, Slav Yartsev, David Roberge, Robert MacRae, Wilson Roa, Valerie Panet-Raymond, Laura Masucci, Brian Yaremko, David D’Souza, David Palma, Tracy Sexton, Edward Yu, Jason R. Pantarotto, Belal Ahmad, Barbara Fisher, A. Rashid Dar, Carole Lambert, Gregory Pond, Larry Stitt, Keng Yeow Tay, George Rodrigues

ABSTRACT

We examined functional outcomes and quality of life of whole brain radiotherapy (WBRT) with integrated fractionated stereotactic radiotherapy boost (FSRT) for brain metastases treatment. Eighty seven people with 1-3 brain metastases (54/87 lung primary, 42/87 single brain metastases) were enrolled on this Phase II trial of WBRT (30 Gy/10) + simultaneous FSRT, (60 Gy/10). Median overall follow-up and survival was 5.4 months, 6 month actuarial intra-lesional control was 78 %; only 1 patient exhibited grade 4 toxicity (worsened seizures); most treatment related toxicity was grade 1 or 2; 2/87 patients demonstrated asymptomatic radiation necrosis on follow-up imaging. Mean (Min-Max) baseline KPS, Mini Mental Status Exam (MMSE) and FACT-BR quality of life were 83 (70-100), 28 (21-30) and 143 (98-153). Lower baseline MMSE (but not KPS or FACT-Br) was associated with worse survival after adjusting for age, number of metastases, primary and extra-cranial disease status. Crude rates of deterioration (>10 points decrease from baseline for KPS and FACT-Br, MMSE fall to <27) ranged from 26 to 38 % for KPS, 32-59 % for FACT-Br and 0-16 % for MMSE depending on the time-point assessed with higher rates generally noted at earlier time points (≤6 months post-treatment). Using a linear mixed models analysis, significant declines from baseline were noted for KPS and FACT-Br (largest effects at 6 weeks to 3 months) with no significant change in MMSE. The effects on function and quality of life of this integrated treatment of WBRT + simultaneous FSRT were similar to other published series combining WBRT + radiosurgery. More... »

PAGES

431-436

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-016-2128-7

DOI

http://dx.doi.org/10.1007/s11060-016-2128-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014077601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27084705


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