Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Stéphane Goutagny, Eric Raymond, Marina Esposito-Farese, Stéphanie Trunet, Christian Mawrin, Daniele Bernardeschi, Béatrice Larroque, Olivier Sterkers, Marco Giovannini, Michel Kalamarides

ABSTRACT

Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was >20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was >20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume ≥20 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to > 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus. More... »

PAGES

313-320

References to SciGraph publications

  • 2014-06. Long-term toxicity of bevacizumab therapy in neurofibromatosis 2 patients in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-014-1710-0

    DOI

    http://dx.doi.org/10.1007/s11060-014-1710-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041205376

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25567352


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cranial Nerve Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Everolimus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mechanistic Target of Rapamycin Complex 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiprotein Complexes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurilemmoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurofibromatosis 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TOR Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Burden", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vestibulocochlear Nerve Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Beaujon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411599.1", 
              "name": [
                "Neurochirurgie, H\u00f4pital Beaujon, Assistance Publique H\u00f4pitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goutagny", 
            "givenName": "St\u00e9phane", 
            "id": "sg:person.01340223651.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340223651.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beaujon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411599.1", 
              "name": [
                "Service interhospitalier de Canc\u00e9rologie, H\u00f4pital Beaujon, Assistance Publique H\u00f4pitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raymond", 
            "givenName": "Eric", 
            "id": "sg:person.0722574726.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722574726.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "D\u00e9partement d\u2019\u00c9pid\u00e9miologie et de Recherche Clinique, H\u00f4pital Bichat, Institut National de la sant\u00e9 et de la recherche m\u00e9dicale CIC-EC 1425, Assistance Publique H\u00f4pitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Esposito-Farese", 
            "givenName": "Marina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne University", 
              "id": "https://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Neuroradiologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
                "Facult\u00e9 de M\u00e9decine, Universit\u00e9 Pierre et Marie Curie, 91-105, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trunet", 
            "givenName": "St\u00e9phanie", 
            "id": "sg:person.01214460115.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214460115.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Otto-von-Guericke University Magdeburg", 
              "id": "https://www.grid.ac/institutes/grid.5807.a", 
              "name": [
                "Department of Neuropathology, Institute of Biology, Otto-von-Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mawrin", 
            "givenName": "Christian", 
            "id": "sg:person.01143304676.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143304676.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Otolaryngologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bernardeschi", 
            "givenName": "Daniele", 
            "id": "sg:person.01260207054.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260207054.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Beaujon Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411599.1", 
              "name": [
                "D\u00e9partment d\u2019\u00c9pid\u00e9miologie et de Recherche Clinique, H\u00f4pital Beaujon, Assistance Publique H\u00f4pitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Larroque", 
            "givenName": "B\u00e9atrice", 
            "id": "sg:person.0722332745.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722332745.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne University", 
              "id": "https://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Otolaryngologie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
                "Facult\u00e9 de M\u00e9decine, Universit\u00e9 Pierre et Marie Curie, 91-105, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sterkers", 
            "givenName": "Olivier", 
            "id": "sg:person.0715002555.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715002555.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California Los Angeles", 
              "id": "https://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, 90095-1624, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giovannini", 
            "givenName": "Marco", 
            "id": "sg:person.0773260420.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773260420.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sorbonne University", 
              "id": "https://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Neurochirurgie, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
                "Facult\u00e9 de M\u00e9decine, Universit\u00e9 Pierre et Marie Curie, 91-105, boulevard de l\u2019H\u00f4pital, 75013, Paris, France", 
                "Institut National de la sant\u00e9 et de la recherche m\u00e9dicale, U1127, Institut cerveau moelle, 47-83, boulevard de l\u2019H\u00f4pital, 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalamarides", 
            "givenName": "Michel", 
            "id": "sg:person.01312773424.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312773424.15"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/sim.721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001557237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01581-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001731182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nos146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005943536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-2550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006790381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0000000000000239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009673788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0000000000000239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009673788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60259-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010222644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0b013e31825e73f5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011431134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0b013e31825e73f5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011431134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/neu.0b013e31828bae28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011734074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014085218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014587996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/01.neu.0000255340.26027.53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014934972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/not150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016956045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017107700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)61134-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019518465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0059941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021611809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-014-2456-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023208536", 
              "https://doi.org/10.1007/s00280-014-2456-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0194-5998(95)70101-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026498764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0194-5998(95)70101-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026498764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0194-5998(95)70101-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026498764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0b013e3181eb328a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027332689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0b013e3181eb328a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027332689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mao.0b013e3181eb328a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027332689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdr012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032333154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa063564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032990918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-11-0425-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036537044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/not242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040120685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000435744.57038.af", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045721308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000435744.57038.af", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045721308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0902579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046343101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1227/neu.0000000000000264", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050597215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.33139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053293570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.33139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053293570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2012.3.jns111649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071077624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2012.3.jns111649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071077624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3171/2012.3.jns111649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071077624"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-04", 
        "datePublishedReg": "2015-04-01", 
        "description": "Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was >20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was >20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume \u226520 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to > 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11060-014-1710-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1094205", 
            "issn": [
              "0167-594X", 
              "1573-7373"
            ], 
            "name": "Journal of Neuro-Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "122"
          }
        ], 
        "name": "Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas", 
        "pagination": "313-320", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c44a147b833b19c060c241ccab49dcd28236f597c495a8dc45f637d3020cbb4c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25567352"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8309335"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11060-014-1710-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1041205376"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11060-014-1710-0", 
          "https://app.dimensions.ai/details/publication/pub.1041205376"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000533.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11060-014-1710-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-014-1710-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-014-1710-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-014-1710-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-014-1710-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    321 TRIPLES      21 PREDICATES      78 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11060-014-1710-0 schema:about N13bfe01de5be42bd80c7ef65d5f167de
    2 N149ddc9e2c5e46c8a74315b279d0eee4
    3 N2dc4bc18428442a69ea256481815a92c
    4 N2e6027557eea495b8b84dd43634af732
    5 N329516b2ff02434c97f8d3d18266d89d
    6 N42ec0624a4c347c3b5d43c469ef78ebb
    7 N44f6ea075f0044ba9d1826a34b66a828
    8 N46357a683b764c14b8c88d3f21c0ed02
    9 N66ba7f16a06d4ac899d5e2e24da243cb
    10 N768bf2f8c2ba4717808a68c637b8776c
    11 N8892373e84ec418aa3bd7df0bafbfbce
    12 N89dea71f824642bfbe20569c1b8cfefc
    13 N8ebbc94a176f4842ba70bedbc7cc4859
    14 Nb967b71b1250446981b6658d0b5a4dfb
    15 Nbd68ad876c5b4fa2930062194b5d4e5f
    16 Nd63f00f46f584b0cafa1236486e995a9
    17 Ndb304dcd8a304067a55bf181bdda28e3
    18 Ne0f06d0732d74e9baa4eed9952408232
    19 Ne9e784b886b84f12ad378937f647a127
    20 Nf241513ec17e4d4a9ff5231afc358c67
    21 Nf3b8477e3e6447b9949d07868b0e9671
    22 Nfa29f8506b5a4b8db649c71f5e3df9c8
    23 anzsrc-for:11
    24 anzsrc-for:1103
    25 schema:author Nd573914adec84c1db1b055f6d415b053
    26 schema:citation sg:pub.10.1007/s00280-014-2456-2
    27 https://doi.org/10.1002/ajmg.a.33139
    28 https://doi.org/10.1002/sim.721
    29 https://doi.org/10.1016/s0140-6736(09)60259-2
    30 https://doi.org/10.1016/s0140-6736(12)61134-9
    31 https://doi.org/10.1016/s0194-5998(95)70101-x
    32 https://doi.org/10.1056/nejmoa063564
    33 https://doi.org/10.1056/nejmoa0902579
    34 https://doi.org/10.1093/annonc/mdq566
    35 https://doi.org/10.1093/annonc/mdr012
    36 https://doi.org/10.1093/neuonc/nos146
    37 https://doi.org/10.1093/neuonc/not150
    38 https://doi.org/10.1093/neuonc/not242
    39 https://doi.org/10.1093/neuonc/nou004
    40 https://doi.org/10.1097/mao.0000000000000239
    41 https://doi.org/10.1097/mao.0b013e3181eb328a
    42 https://doi.org/10.1097/mao.0b013e31825e73f5
    43 https://doi.org/10.1128/mcb.01581-08
    44 https://doi.org/10.1158/1078-0432.ccr-04-2550
    45 https://doi.org/10.1158/1078-0432.ccr-12-1904
    46 https://doi.org/10.1158/1541-7786.mcr-11-0425-t
    47 https://doi.org/10.1212/01.wnl.0000435744.57038.af
    48 https://doi.org/10.1227/01.neu.0000255340.26027.53
    49 https://doi.org/10.1227/neu.0000000000000264
    50 https://doi.org/10.1227/neu.0b013e31828bae28
    51 https://doi.org/10.1371/journal.pone.0059941
    52 https://doi.org/10.3171/2012.3.jns111649
    53 schema:datePublished 2015-04
    54 schema:datePublishedReg 2015-04-01
    55 schema:description Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was >20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was >20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume ≥20 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to > 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus.
    56 schema:genre research_article
    57 schema:inLanguage en
    58 schema:isAccessibleForFree true
    59 schema:isPartOf N8cbbc8649ff64944b7b02d7d8f82dc65
    60 N95f2a8421ee442f5a6a062578361838c
    61 sg:journal.1094205
    62 schema:name Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas
    63 schema:pagination 313-320
    64 schema:productId N1d02ac49fc944b78aaeba88d4e4d02f8
    65 N46439177dc0e4eafb9afe6fc4d2f666a
    66 N5e735c7ede3e40c2909834438c1459c5
    67 Na2bda1bdfe1946a4873fa05da6f3d2cf
    68 Nd9f1eb15c491428aaab95620bc9f5081
    69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041205376
    70 https://doi.org/10.1007/s11060-014-1710-0
    71 schema:sdDatePublished 2019-04-10T16:46
    72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    73 schema:sdPublisher Ne4098cd9013a4b1ea06b3ae75c155d04
    74 schema:url http://link.springer.com/10.1007%2Fs11060-014-1710-0
    75 sgo:license sg:explorer/license/
    76 sgo:sdDataset articles
    77 rdf:type schema:ScholarlyArticle
    78 N0356997d2db84076bbaaad8895791340 rdf:first N80504395b7824b24a2d6a77fed1cb6fa
    79 rdf:rest Nc685f00bfe5946c192d84661686644a6
    80 N11275cdc8d0b4b5ebade10a618dd5bd7 rdf:first sg:person.0722574726.55
    81 rdf:rest N0356997d2db84076bbaaad8895791340
    82 N13bfe01de5be42bd80c7ef65d5f167de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Male
    84 rdf:type schema:DefinedTerm
    85 N149ddc9e2c5e46c8a74315b279d0eee4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Young Adult
    87 rdf:type schema:DefinedTerm
    88 N1d02ac49fc944b78aaeba88d4e4d02f8 schema:name readcube_id
    89 schema:value c44a147b833b19c060c241ccab49dcd28236f597c495a8dc45f637d3020cbb4c
    90 rdf:type schema:PropertyValue
    91 N2dc4bc18428442a69ea256481815a92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Prospective Studies
    93 rdf:type schema:DefinedTerm
    94 N2e6027557eea495b8b84dd43634af732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Adolescent
    96 rdf:type schema:DefinedTerm
    97 N329516b2ff02434c97f8d3d18266d89d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name TOR Serine-Threonine Kinases
    99 rdf:type schema:DefinedTerm
    100 N42ec0624a4c347c3b5d43c469ef78ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Neurofibromatosis 2
    102 rdf:type schema:DefinedTerm
    103 N44f6ea075f0044ba9d1826a34b66a828 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Neurilemmoma
    105 rdf:type schema:DefinedTerm
    106 N46357a683b764c14b8c88d3f21c0ed02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Everolimus
    108 rdf:type schema:DefinedTerm
    109 N46439177dc0e4eafb9afe6fc4d2f666a schema:name pubmed_id
    110 schema:value 25567352
    111 rdf:type schema:PropertyValue
    112 N4904e930dda3443eb195c1adba329ee4 rdf:first sg:person.0773260420.74
    113 rdf:rest N4cd320f5e6e84c298b1cad1a94ecb0c0
    114 N4cd320f5e6e84c298b1cad1a94ecb0c0 rdf:first sg:person.01312773424.15
    115 rdf:rest rdf:nil
    116 N5e735c7ede3e40c2909834438c1459c5 schema:name doi
    117 schema:value 10.1007/s11060-014-1710-0
    118 rdf:type schema:PropertyValue
    119 N66ba7f16a06d4ac899d5e2e24da243cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Disease-Free Survival
    121 rdf:type schema:DefinedTerm
    122 N70171ff616694b11bd16b52391395003 schema:name Département d’Épidémiologie et de Recherche Clinique, Hôpital Bichat, Institut National de la santé et de la recherche médicale CIC-EC 1425, Assistance Publique Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France
    123 rdf:type schema:Organization
    124 N768bf2f8c2ba4717808a68c637b8776c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Mechanistic Target of Rapamycin Complex 1
    126 rdf:type schema:DefinedTerm
    127 N80504395b7824b24a2d6a77fed1cb6fa schema:affiliation N70171ff616694b11bd16b52391395003
    128 schema:familyName Esposito-Farese
    129 schema:givenName Marina
    130 rdf:type schema:Person
    131 N8892373e84ec418aa3bd7df0bafbfbce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Female
    133 rdf:type schema:DefinedTerm
    134 N89dea71f824642bfbe20569c1b8cfefc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Adult
    136 rdf:type schema:DefinedTerm
    137 N8cbbc8649ff64944b7b02d7d8f82dc65 schema:issueNumber 2
    138 rdf:type schema:PublicationIssue
    139 N8ebbc94a176f4842ba70bedbc7cc4859 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Biomarkers, Tumor
    141 rdf:type schema:DefinedTerm
    142 N95f2a8421ee442f5a6a062578361838c schema:volumeNumber 122
    143 rdf:type schema:PublicationVolume
    144 Na2bda1bdfe1946a4873fa05da6f3d2cf schema:name dimensions_id
    145 schema:value pub.1041205376
    146 rdf:type schema:PropertyValue
    147 Nae59b1d69465459ab2d8f4a845fbcebf rdf:first sg:person.01260207054.11
    148 rdf:rest Ne3125212657447bba62cee09d3f9b269
    149 Nb967b71b1250446981b6658d0b5a4dfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Cranial Nerve Neoplasms
    151 rdf:type schema:DefinedTerm
    152 Nbd68ad876c5b4fa2930062194b5d4e5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Vestibulocochlear Nerve Diseases
    154 rdf:type schema:DefinedTerm
    155 Nc685f00bfe5946c192d84661686644a6 rdf:first sg:person.01214460115.26
    156 rdf:rest Nefe907b297134a5d82584613a6d7d319
    157 Nd573914adec84c1db1b055f6d415b053 rdf:first sg:person.01340223651.04
    158 rdf:rest N11275cdc8d0b4b5ebade10a618dd5bd7
    159 Nd63f00f46f584b0cafa1236486e995a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Treatment Outcome
    161 rdf:type schema:DefinedTerm
    162 Nd9f1eb15c491428aaab95620bc9f5081 schema:name nlm_unique_id
    163 schema:value 8309335
    164 rdf:type schema:PropertyValue
    165 Ndb304dcd8a304067a55bf181bdda28e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Disease Progression
    167 rdf:type schema:DefinedTerm
    168 Ne032bde9ca3945bfbda79b2b5de28841 rdf:first sg:person.0715002555.72
    169 rdf:rest N4904e930dda3443eb195c1adba329ee4
    170 Ne0f06d0732d74e9baa4eed9952408232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Follow-Up Studies
    172 rdf:type schema:DefinedTerm
    173 Ne3125212657447bba62cee09d3f9b269 rdf:first sg:person.0722332745.88
    174 rdf:rest Ne032bde9ca3945bfbda79b2b5de28841
    175 Ne4098cd9013a4b1ea06b3ae75c155d04 schema:name Springer Nature - SN SciGraph project
    176 rdf:type schema:Organization
    177 Ne9e784b886b84f12ad378937f647a127 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Humans
    179 rdf:type schema:DefinedTerm
    180 Nefe907b297134a5d82584613a6d7d319 rdf:first sg:person.01143304676.41
    181 rdf:rest Nae59b1d69465459ab2d8f4a845fbcebf
    182 Nf241513ec17e4d4a9ff5231afc358c67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Multiprotein Complexes
    184 rdf:type schema:DefinedTerm
    185 Nf3b8477e3e6447b9949d07868b0e9671 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Antineoplastic Agents
    187 rdf:type schema:DefinedTerm
    188 Nfa29f8506b5a4b8db649c71f5e3df9c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Tumor Burden
    190 rdf:type schema:DefinedTerm
    191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    192 schema:name Medical and Health Sciences
    193 rdf:type schema:DefinedTerm
    194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Clinical Sciences
    196 rdf:type schema:DefinedTerm
    197 sg:journal.1094205 schema:issn 0167-594X
    198 1573-7373
    199 schema:name Journal of Neuro-Oncology
    200 rdf:type schema:Periodical
    201 sg:person.01143304676.41 schema:affiliation https://www.grid.ac/institutes/grid.5807.a
    202 schema:familyName Mawrin
    203 schema:givenName Christian
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143304676.41
    205 rdf:type schema:Person
    206 sg:person.01214460115.26 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
    207 schema:familyName Trunet
    208 schema:givenName Stéphanie
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214460115.26
    210 rdf:type schema:Person
    211 sg:person.01260207054.11 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
    212 schema:familyName Bernardeschi
    213 schema:givenName Daniele
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260207054.11
    215 rdf:type schema:Person
    216 sg:person.01312773424.15 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
    217 schema:familyName Kalamarides
    218 schema:givenName Michel
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312773424.15
    220 rdf:type schema:Person
    221 sg:person.01340223651.04 schema:affiliation https://www.grid.ac/institutes/grid.411599.1
    222 schema:familyName Goutagny
    223 schema:givenName Stéphane
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340223651.04
    225 rdf:type schema:Person
    226 sg:person.0715002555.72 schema:affiliation https://www.grid.ac/institutes/grid.462844.8
    227 schema:familyName Sterkers
    228 schema:givenName Olivier
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715002555.72
    230 rdf:type schema:Person
    231 sg:person.0722332745.88 schema:affiliation https://www.grid.ac/institutes/grid.411599.1
    232 schema:familyName Larroque
    233 schema:givenName Béatrice
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722332745.88
    235 rdf:type schema:Person
    236 sg:person.0722574726.55 schema:affiliation https://www.grid.ac/institutes/grid.411599.1
    237 schema:familyName Raymond
    238 schema:givenName Eric
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722574726.55
    240 rdf:type schema:Person
    241 sg:person.0773260420.74 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
    242 schema:familyName Giovannini
    243 schema:givenName Marco
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773260420.74
    245 rdf:type schema:Person
    246 sg:pub.10.1007/s00280-014-2456-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023208536
    247 https://doi.org/10.1007/s00280-014-2456-2
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/ajmg.a.33139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053293570
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1002/sim.721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001557237
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/s0140-6736(09)60259-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222644
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/s0140-6736(12)61134-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019518465
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/s0194-5998(95)70101-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026498764
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1056/nejmoa063564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032990918
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1056/nejmoa0902579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046343101
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1093/annonc/mdq566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017107700
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1093/annonc/mdr012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032333154
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1093/neuonc/nos146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005943536
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1093/neuonc/not150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016956045
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1093/neuonc/not242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040120685
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1093/neuonc/nou004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014587996
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1097/mao.0000000000000239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009673788
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1097/mao.0b013e3181eb328a schema:sameAs https://app.dimensions.ai/details/publication/pub.1027332689
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1097/mao.0b013e31825e73f5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011431134
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1128/mcb.01581-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001731182
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1158/1078-0432.ccr-04-2550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006790381
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1158/1078-0432.ccr-12-1904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014085218
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1158/1541-7786.mcr-11-0425-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1036537044
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1212/01.wnl.0000435744.57038.af schema:sameAs https://app.dimensions.ai/details/publication/pub.1045721308
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1227/01.neu.0000255340.26027.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014934972
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1227/neu.0000000000000264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050597215
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1227/neu.0b013e31828bae28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011734074
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1371/journal.pone.0059941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611809
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.3171/2012.3.jns111649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071077624
    300 rdf:type schema:CreativeWork
    301 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
    302 schema:name Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave, 90095-1624, Los Angeles, CA, USA
    303 rdf:type schema:Organization
    304 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
    305 schema:name Otolaryngologie, Hôpital Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l’Hôpital, 75013, Paris, France
    306 rdf:type schema:Organization
    307 https://www.grid.ac/institutes/grid.411599.1 schema:alternateName Beaujon Hospital
    308 schema:name Départment d’Épidémiologie et de Recherche Clinique, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France
    309 Neurochirurgie, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France
    310 Service interhospitalier de Cancérologie, Hôpital Beaujon, Assistance Publique Hôpitaux de Paris, 100 boulevard du General Leclerc, 92100, Clichy, France
    311 rdf:type schema:Organization
    312 https://www.grid.ac/institutes/grid.462844.8 schema:alternateName Sorbonne University
    313 schema:name Faculté de Médecine, Université Pierre et Marie Curie, 91-105, boulevard de l’Hôpital, 75013, Paris, France
    314 Institut National de la santé et de la recherche médicale, U1127, Institut cerveau moelle, 47-83, boulevard de l’Hôpital, 75013, Paris, France
    315 Neurochirurgie, Hôpital Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l’Hôpital, 75013, Paris, France
    316 Neuroradiologie, Hôpital Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l’Hôpital, 75013, Paris, France
    317 Otolaryngologie, Hôpital Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, 47-83, boulevard de l’Hôpital, 75013, Paris, France
    318 rdf:type schema:Organization
    319 https://www.grid.ac/institutes/grid.5807.a schema:alternateName Otto-von-Guericke University Magdeburg
    320 schema:name Department of Neuropathology, Institute of Biology, Otto-von-Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    321 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...