PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

Dimitrios Mathios, Jacob Ruzevick, Christopher M. Jackson, Haiying Xu, Sagar Shah, Janis M. Taube, Peter C. Burger, Edward F. McCarthy, Alfredo Quinones-Hinojosa, Drew M. Pardoll, Michael Lim

ABSTRACT

Chordomas are rare malignant tumors that are postulated to arise from remnants of the notochord. Currently, the interaction between chordomas and the host immune system is poorly understood. The checkpoint protein, PD-1 is expressed by circulating lymphocytes and is a marker of activation and exhaustion. Its ligands, PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273), are expressed on a variety of human cancers; however this pathway has not been previously reported in chordomas. We used flow cytometric and RT-PCR analysis in three established primary and recurrent chordoma cell lines (U-CH1, U-CH2, and JHC7) as well as immunohistochemical analysis of chordoma tissues from 10 patients to identify and localize expression of PD-1 pathway proteins. PD-1 ligands are not constitutively expressed by chordoma cells, but their expression is induced in the setting of pro-inflammatory cytokines in all cell lines examined. In paraffin embedded tissues, we found that tumor infiltrating lymphocytes expressed PD-1 in 3/6 cases. We also found that, although chordoma cells did not express significant levels of PD-L1, PD-L1 expression was observed on tumor-infiltrating macrophages and tumor infiltrating lymphocytes. Our study suggests that PD-1, PD-L1, and PD-L2 are present in the microenvironment of a subset of chordomas analyzed. Future studies are needed to evaluate the contribution of the PD-1 pathway to the immunosuppressive microenvironment of chordomas. More... »

PAGES

251-259

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-014-1637-5

DOI

http://dx.doi.org/10.1007/s11060-014-1637-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013143261

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25349132


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Download the RDF metadata as:  json-ld nt turtle xml License info

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-014-1637-5'


 

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300 schema:name Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
301 Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
302 Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
303 Department of Neurosurgery, Johns Hopkins Hospital, 600 N. Wolfe Street, Neurosurgery - Phipps 123, 21287, Baltimore, MD, USA
304 Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
305 Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
306 Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
307 rdf:type schema:Organization
 




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