Multimodality therapy for CNS mixed malignant germ cell tumors (MMGCT): results of a phase II multi-institutional study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

Patricia L. Robertson, Regina Jakacki, Juliette Hukin, Joao Siffert, Jeffrey C. Allen

ABSTRACT

In order to improve outcomes for CNS mixed malignant germ cell tumors (MMGCT) we sought to increase complete responses (CR) to initial therapy, through intensifying neoadjuvant chemotherapy (CHT1) with added ifosfamide, encouraging second-look surgery, and administering dose-intensive, stem cell-supported chemotherapy (CHT2) to patients with residual tumor, all prior to radiation therapy (RT). Diagnosis was confirmed by biopsy or elevated germ cell tumor markers. After tumor staging was completed, patients received four cycles of chemotherapy (cisplatin, etoposide and ifosfamide, "CHT1"). In patients with More... »

PAGES

93-100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-013-1306-0

DOI

http://dx.doi.org/10.1007/s11060-013-1306-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017393847

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24700239


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