Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

Jian He, Jian Wu, Yuchen Jiao, Fausto J. Rodriguez, Jaishri O. Blakeley, Kenneth W. Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Matthias Holdhoff

ABSTRACT

Chemotherapy-based treatment of patients with primary central nervous system lymphoma can lead to durable remissions and potentially cure in a fraction of patients. Accurate assessment of residual disease is necessary to determine the duration and success of treatment that cannot be achieved by contrast-enhanced imaging due to limited sensitivity and specificity. A tumor-derived blood-based biomarker, if detectable and quantifiable, could serve as a more specific and reliable marker for these patients. The goal of this study was to assess whether lymphoma-specific IgH rearrangements can be detected in plasma of patients with PCNSL. PCNSL tissue was analyzed by capturing and sequencing the IgH genomic regions (IgCap) using next generation sequencing with the Illumina platform. Plasma of patients with detected IgH rearrangement was then analyzed for presence of the respective rearrangement using polymerase chain reaction. Tumor tissue and matched plasma of five treatment-naïve patients with biopsy-proven PCNSL (mean age of 65.6 years; range 62-68 years) were analyzed. All patients had measurable contrast-enhancing disease on MRI at time of plasma collection. IgH rearrangements were identified in 4 of 5 analyzed PCNSL tissue samples. The respective rearrangement could be detected in the plasma of 1 patient (25 %) but not in the others. IgH rearrangements can be detected in tumor tissue of patients with PCNSL using IgCap, however, they are absent or only present in minimal quantities in plasma, even in treatment-natïve patients with bulky disease. Alternative strategies to develop circulating biomarkers for PCNSL patients need to be explored. More... »

PAGES

275-279

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-013-1182-7

DOI

http://dx.doi.org/10.1007/s11060-013-1182-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039700888

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23828278


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Heavy Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Non-Hodgkin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm, Residual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Jian", 
        "id": "sg:person.012237203717.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012237203717.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Jian", 
        "id": "sg:person.014003505217.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014003505217.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiao", 
        "givenName": "Yuchen", 
        "id": "sg:person.0631663776.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631663776.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Brain Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1550 Orleans Street, 1M16, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez", 
        "givenName": "Fausto J.", 
        "id": "sg:person.01023212571.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023212571.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Brain Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1550 Orleans Street, 1M16, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blakeley", 
        "givenName": "Jaishri O.", 
        "id": "sg:person.01120225070.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120225070.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinzler", 
        "givenName": "Kenneth W.", 
        "id": "sg:person.0620642630.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Papadopoulos", 
        "givenName": "Nickolas", 
        "id": "sg:person.013623242142.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013623242142.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA", 
            "Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogelstein", 
        "givenName": "Bert", 
        "id": "sg:person.011173760757.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA", 
            "Brain Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1550 Orleans Street, 1M16, 21287, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holdhoff", 
        "givenName": "Matthias", 
        "id": "sg:person.01274302447.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274302447.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2005.13.524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003658256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020101804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.16.9236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023944589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32832f3cb7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32832f3cb7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32832f3cb7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027716225", 
          "https://doi.org/10.1038/sj.leu.2403202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027716225", 
          "https://doi.org/10.1038/sj.leu.2403202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035267668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037860069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042185166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.3541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043187529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djp240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044933543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.06.7165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049550266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051933380", 
          "https://doi.org/10.1038/nm.1789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052077972", 
          "https://doi.org/10.1038/bjc.2011.357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000178894.51436.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000178894.51436.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000178894.51436.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.10502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083942319"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-09", 
    "datePublishedReg": "2013-09-01", 
    "description": "Chemotherapy-based treatment of patients with primary central nervous system lymphoma can lead to durable remissions and potentially cure in a fraction of patients. Accurate assessment of residual disease is necessary to determine the duration and success of treatment that cannot be achieved by contrast-enhanced imaging due to limited sensitivity and specificity. A tumor-derived blood-based biomarker, if detectable and quantifiable, could serve as a more specific and reliable marker for these patients. The goal of this study was to assess whether lymphoma-specific IgH rearrangements can be detected in plasma of patients with PCNSL. PCNSL tissue was analyzed by capturing and sequencing the IgH genomic regions (IgCap) using next generation sequencing with the Illumina platform. Plasma of patients with detected IgH rearrangement was then analyzed for presence of the respective rearrangement using polymerase chain reaction. Tumor tissue and matched plasma of five treatment-na\u00efve patients with biopsy-proven PCNSL (mean age of 65.6 years; range 62-68 years) were analyzed. All patients had measurable contrast-enhancing disease on MRI at time of plasma collection. IgH rearrangements were identified in 4 of 5 analyzed PCNSL tissue samples. The respective rearrangement could be detected in the plasma of 1 patient (25 %) but not in the others. IgH rearrangements can be detected in tumor tissue of patients with PCNSL using IgCap, however, they are absent or only present in minimal quantities in plasma, even in treatment-nat\u00efve patients with bulky disease. Alternative strategies to develop circulating biomarkers for PCNSL patients need to be explored.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11060-013-1182-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438791", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435375", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440186", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "114"
      }
    ], 
    "name": "Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma", 
    "pagination": "275-279", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bd1e02851fd136e6d111ddfe50e267598293b1e494c5e609c3146521491b1dc5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23828278"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309335"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11060-013-1182-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039700888"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11060-013-1182-7", 
      "https://app.dimensions.ai/details/publication/pub.1039700888"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11060-013-1182-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-013-1182-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-013-1182-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-013-1182-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-013-1182-7'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      21 PREDICATES      59 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11060-013-1182-7 schema:about N1f6ecc6ad39a4715b88817126e366d17
2 N24b6c77753ae4b909e4a9a9db7ba61c5
3 N2c3f69157ace40ab8804a0bd8ba9d479
4 N33d00cccbcbe4449bcf954e7520c4b92
5 N34204ff89cbd4ab0ba9a562cde018312
6 N36b03d95a86749b49bda8afeb0815a4d
7 N49c2988e5caa4eb4917bca0fb606446f
8 N5f0dd43e939d4d1280f4a32e0311cf30
9 N6f2b7ccb4a654d6293d2ce53143965f0
10 N70c3d08b261441a293c9a163e7ee00ee
11 N9dbbeaaecf024b28b2a44d3f4be6a751
12 Ndbc2eba7c2bd404bae606c9384e7ef77
13 Nde7cd75c7d584de4a5a22944a1d5d7f9
14 Ne6ebf39371984a07a8b0331654cdce11
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Nd00c21e000a84d9d90bc3587e8f98a94
18 schema:citation sg:pub.10.1038/bjc.2011.357
19 sg:pub.10.1038/nm.1789
20 sg:pub.10.1038/sj.leu.2403202
21 https://doi.org/10.1002/ana.22360
22 https://doi.org/10.1002/cncr.10851
23 https://doi.org/10.1073/pnas.96.16.9236
24 https://doi.org/10.1093/jnci/djp240
25 https://doi.org/10.1097/cco.0b013e32832f3cb7
26 https://doi.org/10.1126/scitranslmed.3002543
27 https://doi.org/10.1158/0008-5472.can-07-0605
28 https://doi.org/10.1200/jco.2005.13.524
29 https://doi.org/10.1200/jco.2006.06.7165
30 https://doi.org/10.1200/jco.2009.26.3541
31 https://doi.org/10.1200/jco.2010.28.15_suppl.10502
32 https://doi.org/10.1212/01.wnl.0000178894.51436.54
33 https://doi.org/10.18632/oncotarget.235
34 schema:datePublished 2013-09
35 schema:datePublishedReg 2013-09-01
36 schema:description Chemotherapy-based treatment of patients with primary central nervous system lymphoma can lead to durable remissions and potentially cure in a fraction of patients. Accurate assessment of residual disease is necessary to determine the duration and success of treatment that cannot be achieved by contrast-enhanced imaging due to limited sensitivity and specificity. A tumor-derived blood-based biomarker, if detectable and quantifiable, could serve as a more specific and reliable marker for these patients. The goal of this study was to assess whether lymphoma-specific IgH rearrangements can be detected in plasma of patients with PCNSL. PCNSL tissue was analyzed by capturing and sequencing the IgH genomic regions (IgCap) using next generation sequencing with the Illumina platform. Plasma of patients with detected IgH rearrangement was then analyzed for presence of the respective rearrangement using polymerase chain reaction. Tumor tissue and matched plasma of five treatment-naïve patients with biopsy-proven PCNSL (mean age of 65.6 years; range 62-68 years) were analyzed. All patients had measurable contrast-enhancing disease on MRI at time of plasma collection. IgH rearrangements were identified in 4 of 5 analyzed PCNSL tissue samples. The respective rearrangement could be detected in the plasma of 1 patient (25 %) but not in the others. IgH rearrangements can be detected in tumor tissue of patients with PCNSL using IgCap, however, they are absent or only present in minimal quantities in plasma, even in treatment-natïve patients with bulky disease. Alternative strategies to develop circulating biomarkers for PCNSL patients need to be explored.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N82721a3d2bae468889233c5275f30210
41 Nf786788e092349c09618edd725b02c1e
42 sg:journal.1094205
43 schema:name Limited detection of IgH gene rearrangements in plasma of patients with primary central nervous system lymphoma
44 schema:pagination 275-279
45 schema:productId N438ca58a5df4491995e2076e526b1be6
46 N600350167c8b4188a4cd42305d32e883
47 N70d2ede4e230487884736679f52b8138
48 Nc169a8ed8a9449bcaeba211f0588bc66
49 Nd0e69715b9a341068aa91b929db21401
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039700888
51 https://doi.org/10.1007/s11060-013-1182-7
52 schema:sdDatePublished 2019-04-10T15:56
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N566ded22a2f94c69b715cea0be0c5088
55 schema:url http://link.springer.com/10.1007%2Fs11060-013-1182-7
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N1f6ecc6ad39a4715b88817126e366d17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Prognosis
61 rdf:type schema:DefinedTerm
62 N24b6c77753ae4b909e4a9a9db7ba61c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Middle Aged
64 rdf:type schema:DefinedTerm
65 N2c3f69157ace40ab8804a0bd8ba9d479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Gene Rearrangement
67 rdf:type schema:DefinedTerm
68 N324cd7f34ebc46b2a9a0be8a034dab69 rdf:first sg:person.013623242142.34
69 rdf:rest Nf8e1bb613c07458e8aeb7feba43f1768
70 N33d00cccbcbe4449bcf954e7520c4b92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Polymerase Chain Reaction
72 rdf:type schema:DefinedTerm
73 N34204ff89cbd4ab0ba9a562cde018312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Magnetic Resonance Imaging
75 rdf:type schema:DefinedTerm
76 N36b03d95a86749b49bda8afeb0815a4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Aged
78 rdf:type schema:DefinedTerm
79 N3b0bfb8eadcc4370b8069353da491ded rdf:first sg:person.0620642630.54
80 rdf:rest N324cd7f34ebc46b2a9a0be8a034dab69
81 N438ca58a5df4491995e2076e526b1be6 schema:name pubmed_id
82 schema:value 23828278
83 rdf:type schema:PropertyValue
84 N49c2988e5caa4eb4917bca0fb606446f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Male
86 rdf:type schema:DefinedTerm
87 N5226fcd024ea45f9a1509fb93a5d1664 rdf:first sg:person.01274302447.28
88 rdf:rest rdf:nil
89 N566ded22a2f94c69b715cea0be0c5088 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N5729e554de5e49778c4a0cb47b80a396 rdf:first sg:person.014003505217.43
92 rdf:rest N847996e666e545018e3f7d5612f33f44
93 N5f0dd43e939d4d1280f4a32e0311cf30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name High-Throughput Nucleotide Sequencing
95 rdf:type schema:DefinedTerm
96 N600350167c8b4188a4cd42305d32e883 schema:name doi
97 schema:value 10.1007/s11060-013-1182-7
98 rdf:type schema:PropertyValue
99 N6f2b7ccb4a654d6293d2ce53143965f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Lymphoma, Non-Hodgkin
101 rdf:type schema:DefinedTerm
102 N70c3d08b261441a293c9a163e7ee00ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Central Nervous System Neoplasms
104 rdf:type schema:DefinedTerm
105 N70d2ede4e230487884736679f52b8138 schema:name nlm_unique_id
106 schema:value 8309335
107 rdf:type schema:PropertyValue
108 N82721a3d2bae468889233c5275f30210 schema:issueNumber 3
109 rdf:type schema:PublicationIssue
110 N847996e666e545018e3f7d5612f33f44 rdf:first sg:person.0631663776.31
111 rdf:rest Nc71041fd46d9457e884b470a92dfc93f
112 N9dbbeaaecf024b28b2a44d3f4be6a751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 Nbb801fb98e894ee4abcdf0558c1fca88 rdf:first sg:person.01120225070.79
116 rdf:rest N3b0bfb8eadcc4370b8069353da491ded
117 Nc169a8ed8a9449bcaeba211f0588bc66 schema:name readcube_id
118 schema:value bd1e02851fd136e6d111ddfe50e267598293b1e494c5e609c3146521491b1dc5
119 rdf:type schema:PropertyValue
120 Nc71041fd46d9457e884b470a92dfc93f rdf:first sg:person.01023212571.19
121 rdf:rest Nbb801fb98e894ee4abcdf0558c1fca88
122 Nd00c21e000a84d9d90bc3587e8f98a94 rdf:first sg:person.012237203717.56
123 rdf:rest N5729e554de5e49778c4a0cb47b80a396
124 Nd0e69715b9a341068aa91b929db21401 schema:name dimensions_id
125 schema:value pub.1039700888
126 rdf:type schema:PropertyValue
127 Ndbc2eba7c2bd404bae606c9384e7ef77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 Nde7cd75c7d584de4a5a22944a1d5d7f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Immunoglobulin Heavy Chains
132 rdf:type schema:DefinedTerm
133 Ne6ebf39371984a07a8b0331654cdce11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Neoplasm, Residual
135 rdf:type schema:DefinedTerm
136 Nf786788e092349c09618edd725b02c1e schema:volumeNumber 114
137 rdf:type schema:PublicationVolume
138 Nf8e1bb613c07458e8aeb7feba43f1768 rdf:first sg:person.011173760757.54
139 rdf:rest N5226fcd024ea45f9a1509fb93a5d1664
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
144 schema:name Oncology and Carcinogenesis
145 rdf:type schema:DefinedTerm
146 sg:grant.2435375 http://pending.schema.org/fundedItem sg:pub.10.1007/s11060-013-1182-7
147 rdf:type schema:MonetaryGrant
148 sg:grant.2438791 http://pending.schema.org/fundedItem sg:pub.10.1007/s11060-013-1182-7
149 rdf:type schema:MonetaryGrant
150 sg:grant.2440186 http://pending.schema.org/fundedItem sg:pub.10.1007/s11060-013-1182-7
151 rdf:type schema:MonetaryGrant
152 sg:journal.1094205 schema:issn 0167-594X
153 1573-7373
154 schema:name Journal of Neuro-Oncology
155 rdf:type schema:Periodical
156 sg:person.01023212571.19 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
157 schema:familyName Rodriguez
158 schema:givenName Fausto J.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023212571.19
160 rdf:type schema:Person
161 sg:person.011173760757.54 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
162 schema:familyName Vogelstein
163 schema:givenName Bert
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54
165 rdf:type schema:Person
166 sg:person.01120225070.79 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
167 schema:familyName Blakeley
168 schema:givenName Jaishri O.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120225070.79
170 rdf:type schema:Person
171 sg:person.012237203717.56 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
172 schema:familyName He
173 schema:givenName Jian
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012237203717.56
175 rdf:type schema:Person
176 sg:person.01274302447.28 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
177 schema:familyName Holdhoff
178 schema:givenName Matthias
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274302447.28
180 rdf:type schema:Person
181 sg:person.013623242142.34 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
182 schema:familyName Papadopoulos
183 schema:givenName Nickolas
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013623242142.34
185 rdf:type schema:Person
186 sg:person.014003505217.43 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
187 schema:familyName Wu
188 schema:givenName Jian
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014003505217.43
190 rdf:type schema:Person
191 sg:person.0620642630.54 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
192 schema:familyName Kinzler
193 schema:givenName Kenneth W.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54
195 rdf:type schema:Person
196 sg:person.0631663776.31 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
197 schema:familyName Jiao
198 schema:givenName Yuchen
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631663776.31
200 rdf:type schema:Person
201 sg:pub.10.1038/bjc.2011.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052077972
202 https://doi.org/10.1038/bjc.2011.357
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nm.1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051933380
205 https://doi.org/10.1038/nm.1789
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/sj.leu.2403202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027716225
208 https://doi.org/10.1038/sj.leu.2403202
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/ana.22360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037860069
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/cncr.10851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020101804
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.96.16.9236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020473434
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/jnci/djp240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044933543
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1097/cco.0b013e32832f3cb7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024454216
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1126/scitranslmed.3002543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042185166
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1158/0008-5472.can-07-0605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023944589
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1200/jco.2005.13.524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003658256
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.2006.06.7165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049550266
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1200/jco.2009.26.3541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043187529
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1200/jco.2010.28.15_suppl.10502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083942319
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1212/01.wnl.0000178894.51436.54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347462
233 rdf:type schema:CreativeWork
234 https://doi.org/10.18632/oncotarget.235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035267668
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.469474.c schema:alternateName Johns Hopkins Medicine
237 schema:name Brain Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1550 Orleans Street, 1M16, 21287, Baltimore, MD, USA
238 Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
239 Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...