A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

Darren Hargrave, Birgit Geoerger, Didier Frappaz, Torsten Pietsch, Lyle Gesner, Laura Cisar, Aurora Breazna, Andrew Dorman, Ofelia Cruz-Martinez, Jose Luis Fuster, Xavier Rialland, Céline Icher, Pierre Leblond, David Ashley, Giorgio Perilongo, Martin Elliott, Martin English, Niels Clausen, Jacques Grill

ABSTRACT

A multicenter, two stage phase II study, investigated irinotecan plus temozolomide in children with newly diagnosed high grade glioma. The primary endpoint was tumor response during a two-cycle treatment window, confirmed by external review committee. Patients received oral temozolomide 100 mg/(m(2) day) (days 1-5) and intravenous irinotecan 10 mg/(m(2) day) (days 1-5 and 8-12) for two 21-day cycles (three cycles for patients exhibiting objective tumor response). Standard treatment was then administered according to local investigator choice. In total 17 patients were enrolled and treated by local investigators. However, central pathology review found three patients did not have a diagnosis of high grade glioma and another four patients did not have evaluable disease according to independent central radiological review. The primary endpoint was based on the first ten evaluable patients as determined by the external review committee. Recruitment was stopped for futility after there were no complete or partial responses during the two-cycle treatment window in the first ten evaluable patients. Five patients had stable disease, and five progressed. Data for secondary endpoints including; time to tumor progression, time to treatment failure, and overall survival is reported. The safety profile of the treatment showed the combination was tolerable with two patients (11.8 %) having grade three nausea, and one (5.9 %) experiencing a grade four neutropenia, leading to permanent discontinuation from adjuvant treatment. Irinotecan plus temozolomide, although well tolerated did not improve outcome over historical controls in this setting. More... »

PAGES

127-134

References to SciGraph publications

  • 2004-12. Phase II study of temozolomide and cisplatin as primary treatment prior to radiotherapy in newly diagnosed glioblastoma multiforme patients with measurable disease. A study of the Spanish Medical Neuro-Oncology Group (GENOM) in JOURNAL OF NEURO-ONCOLOGY
  • 2004-08. Temozolomide in paediatric high-grade glioma: a key for combination therapy? in BRITISH JOURNAL OF CANCER
  • 1994-10. Pre-irradiation chemotherapy in children with high-grade astrocytoma: Tumor response to two cycles of the ‘8-drugs-in-1-day’ regimen in JOURNAL OF NEURO-ONCOLOGY
  • 1998-03. Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2004-01. Phase II Trial of Cisplatin Plus Temozolomide, in Recurrent and Progressive Malignant Glioma Patients in JOURNAL OF NEURO-ONCOLOGY
  • 2009-12. Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy in JOURNAL OF NEURO-ONCOLOGY
  • 2005-09. Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies in BRITISH JOURNAL OF CANCER
  • 2004-04. MGMT: its role in cancer aetiology and cancer therapeutics in NATURE REVIEWS CANCER
  • 2006-02. Temozolomide after Radiotherapy for Newly Diagnosed High-grade Glioma and Unfavorable Low-grade Glioma in Children in JOURNAL OF NEURO-ONCOLOGY
  • 1998-09. Phase I study of temozolomide in paediatric patients with advanced cancer in BRITISH JOURNAL OF CANCER
  • 2006-03. Phase II trial of temozolomide in children with recurrent high-grade glioma in JOURNAL OF NEURO-ONCOLOGY
  • 2007-07-12. The 2007 WHO Classification of Tumours of the Central Nervous System in ACTA NEUROPATHOLOGICA
  • 1989-07. The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial in JOURNAL OF NEURO-ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-013-1098-2

    DOI

    http://dx.doi.org/10.1007/s11060-013-1098-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039243927

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23459995


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