Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Andrea Chassot, Sandra Canale, Pascale Varlet, Stephanie Puget, Thomas Roujeau, Laura Negretti, Frederic Dhermain, Xavier Rialland, Marie Anne Raquin, Jacques Grill, Christelle Dufour

ABSTRACT

The purpose of this study is to evaluate the efficacy and toxicity of radiation therapy (RT) with concurrent temozolomide (TMZ) chemotherapy followed by adjuvant TMZ in children with diffuse intrinsic pontine glioma (DIPG). Newly diagnosed patients younger than 18 years with histologically proven DIPG were treated with focal radiotherapy to a dose of 54 Gy in 30 fractions along with concurrent daily TMZ (75 mg/m(2)/day). Four weeks after completing the initial RT-TMZ schedule, adjuvant TMZ (200 mg/m(2)/day, days 1-5) was given every 28 days up to six cycles. Responses/progressions were assessed by clinical and 2-monthly MRI follow-up studies. Between September 2005 and September 2009, 21 patients with newly diagnosed histologically confirmed DIPG were eligible for this study. Median age at diagnosis was 6.4 years (range 4-16 years). At last update in August 2010, 17 children have died, 1 child was alive with progressive disease and 3 with stable disease. Metastatic relapse was documented in the cerebral site in two patients and in spinal cord in two cases. The median time to progression was 7.5 months (range 28 days-14.5 months) and the median survival was 11.7 months (range 26 days-17.5 months). The 1-year PFS and the 1-year OS were 33 and 50%, respectively. Five patients presented radiological findings compatible with pseudoprogression during the treatment. Haematological toxicity (Grade III/IV thrombocytopenia and leucopenia) was the most commonly found and led to dose reductions of TMZ in 58% of the patients. TMZ with radiation therapy has not yielded any significant improvement in outcome of children with DIPG and is associated with higher toxicity compared with radiotherapy alone. Novel treatment modalities are needed to improve the outcome of these patients. More... »

PAGES

399-407

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-011-0681-7

DOI

http://dx.doi.org/10.1007/s11060-011-0681-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032366821

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21858607


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Stem Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dacarbazine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pons", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Paediatric and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chassot", 
        "givenName": "Andrea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Radiology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Canale", 
        "givenName": "Sandra", 
        "id": "sg:person.01216221236.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216221236.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Hospital Sainte-Anne, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varlet", 
        "givenName": "Pascale", 
        "id": "sg:person.01030642337.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030642337.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Necker-Enfants Malades Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Department of Neurosurgery, Hospital Necker Enfants Malades, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puget", 
        "givenName": "Stephanie", 
        "id": "sg:person.01014552506.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014552506.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Necker-Enfants Malades Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412134.1", 
          "name": [
            "Department of Neurosurgery, Hospital Necker Enfants Malades, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roujeau", 
        "givenName": "Thomas", 
        "id": "sg:person.01207606140.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207606140.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Radiation Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Negretti", 
        "givenName": "Laura", 
        "id": "sg:person.01207557501.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207557501.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Radiation Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dhermain", 
        "givenName": "Frederic", 
        "id": "sg:person.0652067134.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652067134.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Angers", 
          "id": "https://www.grid.ac/institutes/grid.411147.6", 
          "name": [
            "Department of Paediatric Oncology, CHU d\u2019Angers, Angers, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rialland", 
        "givenName": "Xavier", 
        "id": "sg:person.01057654417.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057654417.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Paediatric and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raquin", 
        "givenName": "Marie Anne", 
        "id": "sg:person.01126112153.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126112153.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Paediatric and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grill", 
        "givenName": "Jacques", 
        "id": "sg:person.01000014525.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000014525.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Department of Paediatric and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dufour", 
        "givenName": "Christelle", 
        "id": "sg:person.01061110707.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061110707.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.04.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000356667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00846-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002911049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70125-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004307323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00263825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006733565", 
          "https://doi.org/10.1007/bf00263825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00263825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006733565", 
          "https://doi.org/10.1007/bf00263825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011584247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011584247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-911x(199801)30:1<28::aid-mpo9>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012053457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940915)74:6<1827::aid-cncr2820740628>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015939352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(98)00501-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016610507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(98)00501-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016610507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00381-010-1106-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017285387", 
          "https://doi.org/10.1007/s00381-010-1106-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00381-010-1106-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017285387", 
          "https://doi.org/10.1007/s00381-010-1106-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(06)70615-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017671709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-9029-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019056677", 
          "https://doi.org/10.1007/s11060-005-9029-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-005-9029-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019056677", 
          "https://doi.org/10.1007/s11060-005-9029-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00134-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020234651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(95)00563-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026005891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<685::aid-cncr27>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031533573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033042569", 
          "https://doi.org/10.1038/sj.bjc.6603402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033042569", 
          "https://doi.org/10.1038/sj.bjc.6603402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034299256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(93)90228-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041082657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/noq205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042977035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737140.1.1.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046185918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930815)72:4<1414::aid-cncr2820720442>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046861240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047510080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930815)72:4<1404::aid-cncr2820720441>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051652328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00572-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052261545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.5.1375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns-07/07/0001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/ped-07/07/001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071083857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.5.0691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.5.0691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1989.70.5.0691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.6.1246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074604323"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "The purpose of this study is to evaluate the efficacy and toxicity of radiation therapy (RT) with concurrent temozolomide (TMZ) chemotherapy followed by adjuvant TMZ in children with diffuse intrinsic pontine glioma (DIPG). Newly diagnosed patients younger than 18 years with histologically proven DIPG were treated with focal radiotherapy to a dose of 54 Gy in 30 fractions along with concurrent daily TMZ (75 mg/m(2)/day). Four weeks after completing the initial RT-TMZ schedule, adjuvant TMZ (200 mg/m(2)/day, days 1-5) was given every 28 days up to six cycles. Responses/progressions were assessed by clinical and 2-monthly MRI follow-up studies. Between September 2005 and September 2009, 21 patients with newly diagnosed histologically confirmed DIPG were eligible for this study. Median age at diagnosis was 6.4 years (range 4-16 years). At last update in August 2010, 17 children have died, 1 child was alive with progressive disease and 3 with stable disease. Metastatic relapse was documented in the cerebral site in two patients and in spinal cord in two cases. The median time to progression was 7.5 months (range 28 days-14.5 months) and the median survival was 11.7 months (range 26 days-17.5 months). The 1-year PFS and the 1-year OS were 33 and 50%, respectively. Five patients presented radiological findings compatible with pseudoprogression during the treatment. Haematological toxicity (Grade III/IV thrombocytopenia and leucopenia) was the most commonly found and led to dose reductions of TMZ in 58% of the patients. TMZ with radiation therapy has not yielded any significant improvement in outcome of children with DIPG and is associated with higher toxicity compared with radiotherapy alone. Novel treatment modalities are needed to improve the outcome of these patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11060-011-0681-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "106"
      }
    ], 
    "name": "Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma", 
    "pagination": "399-407", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9a30f4e4b452c7e8bea4d658e7799f9440a51824945e1c48cc36c84dbb5feefd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21858607"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8309335"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11060-011-0681-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032366821"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11060-011-0681-7", 
      "https://app.dimensions.ai/details/publication/pub.1032366821"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11060-011-0681-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-011-0681-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-011-0681-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-011-0681-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-011-0681-7'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      71 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11060-011-0681-7 schema:about N18979b2ec75048bca274ca5a913e1ae3
2 N341dc285e130473b98f49582f1fc52c2
3 N3a14024e37e4483687a3eba22dc07102
4 N83f926fe07a54400b419b4b0f2504610
5 N84c80f0f1d5f4033a07a5c7a3b30cbe0
6 N9d79ad66444c4eb28914e28eaf358b9a
7 Nbfebf9241c444e8a8dd08206ce0bbc13
8 Nc30553e536dc4d6bbf02e02f36285ebf
9 Nc3ca23d22ae748af9a3ac71612172932
10 Nd1451bfb34ca4d68af00881075d397fc
11 Nd6168649178e434ab306cec74f961021
12 Ne81fa4ea5e2c45d0aae6e53b101e02d4
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author Nef73b7b273514a358ca7c9c675c31c70
16 schema:citation sg:pub.10.1007/bf00263825
17 sg:pub.10.1007/s00381-010-1106-1
18 sg:pub.10.1007/s00401-007-0243-4
19 sg:pub.10.1007/s11060-005-9029-5
20 sg:pub.10.1038/sj.bjc.6603402
21 https://doi.org/10.1002/(sici)1096-911x(199801)30:1<28::aid-mpo9>3.0.co;2-2
22 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<685::aid-cncr27>3.0.co;2-k
23 https://doi.org/10.1002/1097-0142(19930815)72:4<1404::aid-cncr2820720441>3.0.co;2-g
24 https://doi.org/10.1002/1097-0142(19930815)72:4<1414::aid-cncr2820720442>3.0.co;2-c
25 https://doi.org/10.1002/1097-0142(19940915)74:6<1827::aid-cncr2820740628>3.0.co;2-q
26 https://doi.org/10.1002/cncr.20741
27 https://doi.org/10.1002/cncr.24663
28 https://doi.org/10.1002/pbc.21154
29 https://doi.org/10.1016/0360-3016(93)90228-n
30 https://doi.org/10.1016/0360-3016(95)00563-e
31 https://doi.org/10.1016/j.ijrobp.2009.04.031
32 https://doi.org/10.1016/s0360-3016(97)00134-x
33 https://doi.org/10.1016/s0360-3016(97)00572-5
34 https://doi.org/10.1016/s0360-3016(97)00846-8
35 https://doi.org/10.1016/s0360-3016(98)00501-x
36 https://doi.org/10.1016/s1470-2045(06)70615-5
37 https://doi.org/10.1016/s1470-2045(08)70125-6
38 https://doi.org/10.1056/nejmoa043330
39 https://doi.org/10.1093/neuonc/noq205
40 https://doi.org/10.1200/jco.20.5.1375
41 https://doi.org/10.1200/jco.2000.18.6.1246
42 https://doi.org/10.1586/14737140.1.1.13
43 https://doi.org/10.3171/jns-07/07/0001
44 https://doi.org/10.3171/jns.1989.70.5.0691
45 https://doi.org/10.3171/ped-07/07/001
46 schema:datePublished 2012-01
47 schema:datePublishedReg 2012-01-01
48 schema:description The purpose of this study is to evaluate the efficacy and toxicity of radiation therapy (RT) with concurrent temozolomide (TMZ) chemotherapy followed by adjuvant TMZ in children with diffuse intrinsic pontine glioma (DIPG). Newly diagnosed patients younger than 18 years with histologically proven DIPG were treated with focal radiotherapy to a dose of 54 Gy in 30 fractions along with concurrent daily TMZ (75 mg/m(2)/day). Four weeks after completing the initial RT-TMZ schedule, adjuvant TMZ (200 mg/m(2)/day, days 1-5) was given every 28 days up to six cycles. Responses/progressions were assessed by clinical and 2-monthly MRI follow-up studies. Between September 2005 and September 2009, 21 patients with newly diagnosed histologically confirmed DIPG were eligible for this study. Median age at diagnosis was 6.4 years (range 4-16 years). At last update in August 2010, 17 children have died, 1 child was alive with progressive disease and 3 with stable disease. Metastatic relapse was documented in the cerebral site in two patients and in spinal cord in two cases. The median time to progression was 7.5 months (range 28 days-14.5 months) and the median survival was 11.7 months (range 26 days-17.5 months). The 1-year PFS and the 1-year OS were 33 and 50%, respectively. Five patients presented radiological findings compatible with pseudoprogression during the treatment. Haematological toxicity (Grade III/IV thrombocytopenia and leucopenia) was the most commonly found and led to dose reductions of TMZ in 58% of the patients. TMZ with radiation therapy has not yielded any significant improvement in outcome of children with DIPG and is associated with higher toxicity compared with radiotherapy alone. Novel treatment modalities are needed to improve the outcome of these patients.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N15fa3792a4664973bdc5e7557a01391d
53 Nb1f6f39965e748cbb7019059a0eeb8c7
54 sg:journal.1094205
55 schema:name Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma
56 schema:pagination 399-407
57 schema:productId N20d92f6216b947d3856317c6a891ae0c
58 N36c233ef0ab24c60bf1de023d061e5fc
59 N67ee546fc5d14ce88c1f3340c6f877d1
60 Ncc5f329caea94f97bc120996b44a66f1
61 Nd55d3ebd28b64505b6df1c2add16cf18
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032366821
63 https://doi.org/10.1007/s11060-011-0681-7
64 schema:sdDatePublished 2019-04-10T14:14
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher Nd3d8a51b82054e269aa6cd1f07a77286
67 schema:url http://link.springer.com/10.1007%2Fs11060-011-0681-7
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N15fa3792a4664973bdc5e7557a01391d schema:issueNumber 2
72 rdf:type schema:PublicationIssue
73 N18979b2ec75048bca274ca5a913e1ae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Child
75 rdf:type schema:DefinedTerm
76 N20d92f6216b947d3856317c6a891ae0c schema:name doi
77 schema:value 10.1007/s11060-011-0681-7
78 rdf:type schema:PropertyValue
79 N341dc285e130473b98f49582f1fc52c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Antineoplastic Agents
81 rdf:type schema:DefinedTerm
82 N36c233ef0ab24c60bf1de023d061e5fc schema:name readcube_id
83 schema:value 9a30f4e4b452c7e8bea4d658e7799f9440a51824945e1c48cc36c84dbb5feefd
84 rdf:type schema:PropertyValue
85 N379304f7bcce42338189a5de3993456e rdf:first sg:person.01000014525.40
86 rdf:rest N552fd40979054895b679493127197f63
87 N3a14024e37e4483687a3eba22dc07102 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Humans
89 rdf:type schema:DefinedTerm
90 N3c30306036cb444589887ccb689500b2 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
91 schema:familyName Chassot
92 schema:givenName Andrea
93 rdf:type schema:Person
94 N51155376d0bc4dc7a24fe42d58f79678 rdf:first sg:person.01216221236.30
95 rdf:rest Ncdbe7be05ee64c72945e794ac8089db8
96 N552fd40979054895b679493127197f63 rdf:first sg:person.01061110707.21
97 rdf:rest rdf:nil
98 N67ee546fc5d14ce88c1f3340c6f877d1 schema:name pubmed_id
99 schema:value 21858607
100 rdf:type schema:PropertyValue
101 N754bc8859cc94050a4fc587517346293 rdf:first sg:person.01057654417.64
102 rdf:rest Nd355a5e3899d4a73acc03ed66b44ac67
103 N83f926fe07a54400b419b4b0f2504610 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Pons
105 rdf:type schema:DefinedTerm
106 N84c80f0f1d5f4033a07a5c7a3b30cbe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Dacarbazine
108 rdf:type schema:DefinedTerm
109 N9d79ad66444c4eb28914e28eaf358b9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Adult
111 rdf:type schema:DefinedTerm
112 Nb1f6f39965e748cbb7019059a0eeb8c7 schema:volumeNumber 106
113 rdf:type schema:PublicationVolume
114 Nbfebf9241c444e8a8dd08206ce0bbc13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Disease-Free Survival
116 rdf:type schema:DefinedTerm
117 Nc30553e536dc4d6bbf02e02f36285ebf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Brain Stem Neoplasms
119 rdf:type schema:DefinedTerm
120 Nc3ca23d22ae748af9a3ac71612172932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Child, Preschool
122 rdf:type schema:DefinedTerm
123 Nc948be10c49f43428a163f06a11a5744 rdf:first sg:person.0652067134.98
124 rdf:rest N754bc8859cc94050a4fc587517346293
125 Ncbe2ca91df8946388dbbbfa48e7e2796 rdf:first sg:person.01207606140.34
126 rdf:rest Ne38faffaf24f4b0eb465daac4d84dfdb
127 Ncc5f329caea94f97bc120996b44a66f1 schema:name nlm_unique_id
128 schema:value 8309335
129 rdf:type schema:PropertyValue
130 Ncdbe7be05ee64c72945e794ac8089db8 rdf:first sg:person.01030642337.37
131 rdf:rest Nd0f75eb6ce954e79a5a980fec6707790
132 Nd0f75eb6ce954e79a5a980fec6707790 rdf:first sg:person.01014552506.32
133 rdf:rest Ncbe2ca91df8946388dbbbfa48e7e2796
134 Nd1451bfb34ca4d68af00881075d397fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Kaplan-Meier Estimate
136 rdf:type schema:DefinedTerm
137 Nd355a5e3899d4a73acc03ed66b44ac67 rdf:first sg:person.01126112153.57
138 rdf:rest N379304f7bcce42338189a5de3993456e
139 Nd3d8a51b82054e269aa6cd1f07a77286 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 Nd55d3ebd28b64505b6df1c2add16cf18 schema:name dimensions_id
142 schema:value pub.1032366821
143 rdf:type schema:PropertyValue
144 Nd6168649178e434ab306cec74f961021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Chemoradiotherapy
146 rdf:type schema:DefinedTerm
147 Ne38faffaf24f4b0eb465daac4d84dfdb rdf:first sg:person.01207557501.28
148 rdf:rest Nc948be10c49f43428a163f06a11a5744
149 Ne81fa4ea5e2c45d0aae6e53b101e02d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Neoplasm Grading
151 rdf:type schema:DefinedTerm
152 Nead3fff548fb45889a8c4e00a76e8d6e schema:name Department of Pathology, Hospital Sainte-Anne, Paris, France
153 rdf:type schema:Organization
154 Nef73b7b273514a358ca7c9c675c31c70 rdf:first N3c30306036cb444589887ccb689500b2
155 rdf:rest N51155376d0bc4dc7a24fe42d58f79678
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
160 schema:name Oncology and Carcinogenesis
161 rdf:type schema:DefinedTerm
162 sg:journal.1094205 schema:issn 0167-594X
163 1573-7373
164 schema:name Journal of Neuro-Oncology
165 rdf:type schema:Periodical
166 sg:person.01000014525.40 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
167 schema:familyName Grill
168 schema:givenName Jacques
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000014525.40
170 rdf:type schema:Person
171 sg:person.01014552506.32 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
172 schema:familyName Puget
173 schema:givenName Stephanie
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014552506.32
175 rdf:type schema:Person
176 sg:person.01030642337.37 schema:affiliation Nead3fff548fb45889a8c4e00a76e8d6e
177 schema:familyName Varlet
178 schema:givenName Pascale
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030642337.37
180 rdf:type schema:Person
181 sg:person.01057654417.64 schema:affiliation https://www.grid.ac/institutes/grid.411147.6
182 schema:familyName Rialland
183 schema:givenName Xavier
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057654417.64
185 rdf:type schema:Person
186 sg:person.01061110707.21 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
187 schema:familyName Dufour
188 schema:givenName Christelle
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061110707.21
190 rdf:type schema:Person
191 sg:person.01126112153.57 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
192 schema:familyName Raquin
193 schema:givenName Marie Anne
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126112153.57
195 rdf:type schema:Person
196 sg:person.01207557501.28 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
197 schema:familyName Negretti
198 schema:givenName Laura
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207557501.28
200 rdf:type schema:Person
201 sg:person.01207606140.34 schema:affiliation https://www.grid.ac/institutes/grid.412134.1
202 schema:familyName Roujeau
203 schema:givenName Thomas
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207606140.34
205 rdf:type schema:Person
206 sg:person.01216221236.30 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
207 schema:familyName Canale
208 schema:givenName Sandra
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216221236.30
210 rdf:type schema:Person
211 sg:person.0652067134.98 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
212 schema:familyName Dhermain
213 schema:givenName Frederic
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652067134.98
215 rdf:type schema:Person
216 sg:pub.10.1007/bf00263825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006733565
217 https://doi.org/10.1007/bf00263825
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s00381-010-1106-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017285387
220 https://doi.org/10.1007/s00381-010-1106-1
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
223 https://doi.org/10.1007/s00401-007-0243-4
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s11060-005-9029-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019056677
226 https://doi.org/10.1007/s11060-005-9029-5
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/sj.bjc.6603402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033042569
229 https://doi.org/10.1038/sj.bjc.6603402
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/(sici)1096-911x(199801)30:1<28::aid-mpo9>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012053457
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/(sici)1097-0142(20000201)88:3<685::aid-cncr27>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1031533573
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/1097-0142(19930815)72:4<1404::aid-cncr2820720441>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1051652328
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/1097-0142(19930815)72:4<1414::aid-cncr2820720442>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046861240
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/1097-0142(19940915)74:6<1827::aid-cncr2820740628>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1015939352
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/cncr.20741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034299256
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/cncr.24663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011584247
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/pbc.21154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047510080
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0360-3016(93)90228-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1041082657
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0360-3016(95)00563-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1026005891
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.ijrobp.2009.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000356667
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0360-3016(97)00134-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020234651
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0360-3016(97)00572-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052261545
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0360-3016(97)00846-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002911049
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0360-3016(98)00501-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016610507
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s1470-2045(06)70615-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017671709
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s1470-2045(08)70125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004307323
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/neuonc/noq205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042977035
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1200/jco.20.5.1375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202862
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1200/jco.2000.18.6.1246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074604323
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1586/14737140.1.1.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046185918
274 rdf:type schema:CreativeWork
275 https://doi.org/10.3171/jns-07/07/0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083247
276 rdf:type schema:CreativeWork
277 https://doi.org/10.3171/jns.1989.70.5.0691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071095368
278 rdf:type schema:CreativeWork
279 https://doi.org/10.3171/ped-07/07/001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071083857
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
282 schema:name Department of Paediatric and Adolescent Oncology, Institute Gustave Roussy, Villejuif, France
283 Department of Radiation Oncology, Institute Gustave Roussy, Villejuif, France
284 Department of Radiology, Institute Gustave Roussy, Villejuif, France
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.411147.6 schema:alternateName Centre Hospitalier Universitaire de Angers
287 schema:name Department of Paediatric Oncology, CHU d’Angers, Angers, France
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.412134.1 schema:alternateName Necker-Enfants Malades Hospital
290 schema:name Department of Neurosurgery, Hospital Necker Enfants Malades, Paris, France
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...