Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

Brigitte Wrede, Martin Hasselblatt, Ove Peters, Peter F. Thall, Tezer Kutluk, Albert Moghrabi, Anita Mahajan, Stefan Rutkowski, Blanca Diez, Xuemei Wang, Torsten Pietsch, Rolf-Dieter Kortmann, Werner Paulus, Astrid Jeibmann, Johannes E. A. Wolff

ABSTRACT

Atypical choroid plexus papilloma (APP) represents a novel intermediate-grade subtype of choroid plexus tumor (CPT), the clinical outcome of which has not been described yet. We present the first analysis of a group of APP patients enrolled in the ongoing CPT-SIOP-2000 study of CPTs. A worldwide registration and a randomized trial for those patients who require chemotherapy started in 2000. For APP, maximal surgical resection was recommended. After surgery, patients who had undergone complete resection were observed, whereas patients with incompletely resected or metastasized APP were treated with six chemotherapy courses (etoposide and vincristine, combined with either carboplatin or cyclophosphamide). Risk-adapted radiotherapy was given only to patients older than 3 years of age. Of the 106 patients with a centrally confirmed CPT histology, 30 had APP, 42 CPP and 34 CPC. APP patients were significantly younger (median = 0.7 years) than patients with CPP or CPC (both medians = 2.3 years). Complete resection was achieved in 68 (64%) patients (79% in CPP, 63% in APP, and 47% in CPC). Metastases were present at diagnosis in 17% of APP patients, 5% of CPP patients, and 21% of CPC patients. All nine APP patients who received postoperative chemotherapy showed an early response after two cycles: two had complete remission, four had partial response, and three had stable disease. In the observation group of 15 patients, one event was seen, and all patients were alive. In the treatment group, one patient with a metastasized tumor and incompletely resected APP died. While APP was defined histologically, median percentages of both the Ki-67/MIB-1 proliferation marker and the p53 tumor suppressor protein increased across the three histological subtypes (from CPP to APP and then CPC), suggesting that the subtypes comprise an ordinal categorization of increasingly severe CPT tumors. This ordering was reiterated by clinical outcome in the 92 patients treated per the study protocol, with 5-year EFS rates of 92% in 39 CPP patients, 83% in 24 APP patients, and 28% in 29 CPC patients. A similar ordering was seen when all 106 patients were evaluated for EFS. APP responded favorably to chemotherapy. The intermediate position of APP between CPP and CPC was supported by the clinical data. More... »

PAGES

383-392

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-009-9936-y

DOI

http://dx.doi.org/10.1007/s11060-009-9936-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033440614

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19543851


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438 schema:name Department of Radiotherapy, University of Leipzig, Leipzig, Germany
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