Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-20

AUTHORS

Delia Kurzwelly, Martin Glas, Patrick Roth, Elke Weimann, Hanns Lohner, Andreas Waha, Martin Schabet, Guido Reifenberger, Michael Weller, Ulrich Herrlinger

ABSTRACT

This retrospective series explores temozolomide monotherapy in elderly patients with primary CNS lymphoma (PCNSL) and severe comorbidities. In 17 patients (62–90 years old), the complete response rate was 47%, median progression-free survival was 5 months, and median overall survival was 21 months. Five of 17 patients (29.4%) had prolonged responses for at least 12 months and survived for more than 24 months. Three of these patients had a methylated O6-methylguanine-DNA methyltransferase (MGMT) promoter, while the MGMT status was not assessable in the remaining two patients. Temozolomide monotherapy appears to be effective in a subgroup of elderly PCNSL patients and deserves further evaluation. More... »

PAGES

389-392

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-009-0032-0

DOI

http://dx.doi.org/10.1007/s11060-009-0032-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036537246

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19841864


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